INT11325

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Context Info
Confidence 0.76
First Reported 1988
Last Reported 2011
Negated 11
Speculated 7
Reported most in Abstract
Documents 209
Total Number 235
Disease Relevance 98.05
Pain Relevance 33.72

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (HLA-E)
Anatomy Link Frequency
T cells 21
microglia 11
lymphocytes 7
brain 6
B cells 5
HLA-E (Homo sapiens)
Pain Link Frequency Relevance Heat
Arthritis 848 100.00 Very High Very High Very High
spinal inflammation 132 100.00 Very High Very High Very High
c fibre 13 99.98 Very High Very High Very High
Inflammation 2391 99.80 Very High Very High Very High
Substantia nigra 591 99.68 Very High Very High Very High
aspirin 501 99.60 Very High Very High Very High
cytokine 1587 99.58 Very High Very High Very High
midbrain 72 99.36 Very High Very High Very High
Peripheral nervous system 45 99.36 Very High Very High Very High
imagery 110 98.88 Very High Very High Very High
Disease Link Frequency Relevance Heat
Acquired Immune Deficiency Syndrome Or Hiv Infection 167 100.00 Very High Very High Very High
Juvenile Chronic Polyarthritis 158 100.00 Very High Very High Very High
Low Back Pain 111 100.00 Very High Very High Very High
Cancer 1824 99.98 Very High Very High Very High
Arthritis 670 99.98 Very High Very High Very High
Seronegative Spondarthritis 183 99.98 Very High Very High Very High
Disease 2460 99.84 Very High Very High Very High
Endometriosis 519 99.84 Very High Very High Very High
INFLAMMATION 2616 99.80 Very High Very High Very High
Death 785 99.72 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Because MHC alleles are expressed codominantly, MHC heterozygotes should be able to detect a broader range of pathogens than homozygotes [12], [16], [17].
Gene_expression (expressed) of MHC
1) Confidence 0.76 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2712076 Disease Relevance 0.88 Pain Relevance 0
Biochemical analysis revealed that all C-fibers coexpressed myosin heavy chains (MHC) I and IIa in variable ratios.
Gene_expression (coexpressed) of MHC associated with c fibre
2) Confidence 0.75 Published 1992 Journal J. Histochem. Cytochem. Section Abstract Doc Link 1552189 Disease Relevance 0 Pain Relevance 0.50
To investigate the expression of MHCI genes in the marmoset LGN and primary visual cortex, a full-length clone of the heavy chain (HC) of the classical marmoset MHCI gene Caja-G [accession number U59637 [38]) was used for in situ hybridization experiments.
Spec (investigate) Gene_expression (expression) of MHC in primary visual cortex
3) Confidence 0.75 Published 2011 Journal Behav Brain Funct Section Body Doc Link PMC3023691 Disease Relevance 0 Pain Relevance 0
Even so, the present data showed that MHCI genes are strongly expressed throughout all regions of the visual cortex of the marmoset.
Gene_expression (expressed) of MHC in cortex
4) Confidence 0.75 Published 2011 Journal Behav Brain Funct Section Body Doc Link PMC3023691 Disease Relevance 0 Pain Relevance 0
Furthermore, the aforementioned protein expression pattern of these MHC isoforms in skeletal muscle has been highly correlated with muscular hypertrophy [42].
Gene_expression (expression) of MHC in skeletal muscle associated with hypertrophy
5) Confidence 0.75 Published 2007 Journal J Int Soc Sports Nutr Section Body Doc Link PMC2217562 Disease Relevance 0.43 Pain Relevance 0.12
The present study clearly showed that MHCI molecules are expressed on MAP-2 positive neurons of V1.
Gene_expression (expressed) of MHC in neurons
6) Confidence 0.75 Published 2011 Journal Behav Brain Funct Section Body Doc Link PMC3023691 Disease Relevance 0 Pain Relevance 0
Analysis of expression levels of MHCI molecules in the developing visual cortex of the common marmoset monkeys revealed a distinct spatio-temporal pattern.
Gene_expression (expression) of MHC in cortex
7) Confidence 0.75 Published 2011 Journal Behav Brain Funct Section Abstract Doc Link PMC3023691 Disease Relevance 0 Pain Relevance 0
As a fast evolutionary rate may generate distinct properties of molecules in different mammalian species, we studied the expression of MHCI molecules in a nonhuman primate, the common marmoset monkey (Callithrix jacchus).


Gene_expression (expression) of MHC
8) Confidence 0.75 Published 2011 Journal Behav Brain Funct Section Abstract Doc Link PMC3023691 Disease Relevance 0 Pain Relevance 0
It is possible that MHCI genes are expressed prenatally in the marmoset LGN, as the segregation of LGN layers in primates occurs in utero [39,40].
Gene_expression (expressed) of MHC
9) Confidence 0.75 Published 2011 Journal Behav Brain Funct Section Body Doc Link PMC3023691 Disease Relevance 0 Pain Relevance 0
To determine whether the expression of MHCI molecules is regulated by retinal activity, animals were subjected to monocular enucleation.
Gene_expression (expression) of MHC
10) Confidence 0.75 Published 2011 Journal Behav Brain Funct Section Abstract Doc Link PMC3023691 Disease Relevance 0 Pain Relevance 0
The immunohistological analysis of the endomyocardial biopsy specimens revealed pathologically increased lymphocytic infiltrates and increased expression of interstitial and endothelial MHC I and II antigens.
Gene_expression (expression) of MHC
11) Confidence 0.75 Published 2002 Journal Z Kardiol Section Body Doc Link 12132290 Disease Relevance 0.16 Pain Relevance 0
Infiltration of the pancreas by particular subsets of immune effector cells, aberrant and enhanced expression of MHC molecules, and overexpression of growth factors and their receptors have all recently been found to play a role in CP.
Gene_expression (expression) of MHC in pancreas associated with chronic pancreatitis
12) Confidence 0.75 Published 2001 Journal Zentralbl Chir Section Abstract Doc Link 11753795 Disease Relevance 0.75 Pain Relevance 0.58
MHCI expression in the visual cortex is activity dependent
Gene_expression (expression) of MHC in cortex
13) Confidence 0.75 Published 2011 Journal Behav Brain Funct Section Body Doc Link PMC3023691 Disease Relevance 0 Pain Relevance 0
A normal PHA-induced interleukin-2 receptor expression and lymphocyte proliferation but a low IFN-gamma secretion and MHC locus II antigen expression were observed.
Gene_expression (expression) of MHC in lymphocyte
14) Confidence 0.75 Published 1989 Journal J. Neurol. Sci. Section Abstract Doc Link 2723673 Disease Relevance 1.10 Pain Relevance 0.99
Virtually all nucleated cells express MHCI proteins, usually in their heterotrimeric form; however, their expression on neurons was always debated [9].
Gene_expression (express) of MHC in neurons
15) Confidence 0.75 Published 2011 Journal Behav Brain Funct Section Body Doc Link PMC3023691 Disease Relevance 0 Pain Relevance 0
Immunocytochemistry revealed only occasional lymphocyte infiltration but there was increased Class I and Class II MHC antigen expression throughout the peripheral nervous system.
Gene_expression (expression) of MHC in lymphocyte associated with peripheral nervous system
16) Confidence 0.75 Published 1989 Journal Neuropathol. Appl. Neurobiol. Section Abstract Doc Link 2787483 Disease Relevance 0.73 Pain Relevance 0.30
Increased numbers of T-cells in the synovial fluid from patients with ankylosing spondylitis expressed class II MHC antigens.
Gene_expression (expressed) of MHC in synovial fluid associated with spinal inflammation
17) Confidence 0.75 Published 1988 Journal Clin. Rheumatol. Section Abstract Doc Link 3261676 Disease Relevance 0.90 Pain Relevance 0.54
Expression of MHC class II molecules is restricted to a few macrophage-like cells.
Gene_expression (Expression) of MHC in macrophage
18) Confidence 0.75 Published 1994 Journal Baillieres Clin Neurol Section Abstract Doc Link 7921591 Disease Relevance 0.66 Pain Relevance 0.23
In EAE ultrastructural analysis revealed that MHC antigen expression is pronounced on perivascular microglial cells, suggesting this cell population may be important for antigen presentation at a site close to the blood-brain barrier.
Gene_expression (expression) of MHC in microglial cells associated with multiple sclerosis
19) Confidence 0.75 Published 1993 Journal Glia Section Abstract Doc Link 8380791 Disease Relevance 1.07 Pain Relevance 0.58
Activated microglial cells show an increased expression of MHC class I and II antigens.
Gene_expression (expression) of MHC in microglial cells
20) Confidence 0.75 Published 1993 Journal Glia Section Abstract Doc Link 8380791 Disease Relevance 1.00 Pain Relevance 0.54

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