INT113250

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Context Info
Confidence 0.01
First Reported 2003
Last Reported 2003
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 4
Disease Relevance 0.38
Pain Relevance 0.83

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nuclear envelope (Ache) Golgi apparatus (Ache) cytoplasm (Ache)
signal transducer activity (Olr1259) extracellular space (Ache) extracellular region (Ache)
Anatomy Link Frequency
brain 1
Olr1259 (Rattus norvegicus)
Ache (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Serotonin 8 100.00 Very High Very High Very High
Hippocampus 8 87.60 High High
fluoxetine 4 79.52 Quite High
Disease Link Frequency Relevance Heat
Disease 8 97.04 Very High Very High Very High
Cognitive Disorder 8 58.56 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
RS-1259 simultaneously inhibited AChE and SERT in the brain following an oral administration in mice and rats.
RS-1259 Negative_regulation (inhibited) of AChE in brain
1) Confidence 0.01 Published 2003 Journal J. Pharmacol. Sci. Section Abstract Doc Link 14501158 Disease Relevance 0.07 Pain Relevance 0.21
A dual inhibitor of acetylcholinesterase (AChE) and serotonin transporter (SERT), RS-1259 (4-[1S)-methylamino-3-(4-nitrophenoxy)]propylphenyl N,N-dimethylcarbamate (fumaric acid)(1/2)salt), was newly synthesized.
RS-1259 Negative_regulation (inhibitor) of acetylcholinesterase associated with serotonin
2) Confidence 0.01 Published 2003 Journal J. Pharmacol. Sci. Section Abstract Doc Link 14501158 Disease Relevance 0.07 Pain Relevance 0.19
Pharmacological characterization of RS-1259, an orally active dual inhibitor of acetylcholinesterase and serotonin transporter, in rodents: possible treatment of Alzheimer's disease.
RS-1259 Negative_regulation (inhibitor) of acetylcholinesterase associated with disease and serotonin
3) Confidence 0.01 Published 2003 Journal J. Pharmacol. Sci. Section Title Doc Link 14501158 Disease Relevance 0.16 Pain Relevance 0.24
A dual inhibitor of acetylcholinesterase (AChE) and serotonin transporter (SERT), RS-1259 (4-[1S)-methylamino-3-(4-nitrophenoxy)]propylphenyl N,N-dimethylcarbamate (fumaric acid)(1/2)salt), was newly synthesized.
RS-1259 Negative_regulation (inhibitor) of AChE associated with serotonin
4) Confidence 0.01 Published 2003 Journal J. Pharmacol. Sci. Section Abstract Doc Link 14501158 Disease Relevance 0.07 Pain Relevance 0.19

General Comments

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