INT113254

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Context Info
Confidence 0.09
First Reported 2003
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 13
Total Number 14
Disease Relevance 2.52
Pain Relevance 5.56

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (MFGE8) extracellular region (MFGE8) cell adhesion (MFGE8)
Anatomy Link Frequency
cortex 2
brain 1
amygdala 1
lobe 1
prefrontal 1
MFGE8 (Homo sapiens)
Pain Link Frequency Relevance Heat
Transcranial magnetic stimulation 1526 99.76 Very High Very High Very High
Pain 114 98.54 Very High Very High Very High
Anterior cingulate 2 98.32 Very High Very High Very High
Thalamus 6 96.52 Very High Very High Very High
Analgesic 1 96.32 Very High Very High Very High
amygdala 20 95.62 Very High Very High Very High
Anterior cingulate cortex 25 95.16 Very High Very High Very High
imagery 60 90.76 High High
positron emission tomography 10 81.00 Quite High
poststroke pain 5 75.00 Quite High
Disease Link Frequency Relevance Heat
Pain 80 97.20 Very High Very High Very High
Cognitive Disorder 98 88.40 High High
Increased Venous Pressure Under Development 1 79.08 Quite High
Urological Neuroanatomy 1 61.60 Quite High
Headache 7 17.44 Low Low
Epilepsy 11 16.72 Low Low
Phobia 22 5.00 Very Low Very Low Very Low
Appetite Loss 20 5.00 Very Low Very Low Very Low
Anxiety Disorder 8 5.00 Very Low Very Low Very Low
Unconsciousness 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Therefore, this study provides indirect evidence (constituted by our offline TMS over MFG results) for the functional relevance of remote neural effects of TMS (the decrease of MFG activation found by Sack et al. [21] during TMS over PPC).
Positive_regulation (activation) of MFG in neural associated with transcranial magnetic stimulation
1) Confidence 0.09 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2789405 Disease Relevance 0 Pain Relevance 0.47
We subsequently used fMRI EC-guided TMS Neuronavigation for each participant, in order to apply TMS in four experimental time windows over both regions; the task-specifically activated right PPC as well as the task-specifically effectively connected right MFG.
Positive_regulation (activated) of MFG associated with transcranial magnetic stimulation
2) Confidence 0.08 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2789405 Disease Relevance 0 Pain Relevance 0.27
Thus, in stimulating MFG in different participants, the effect of TMS was dependent on an interaction between the individual cortical excitability and the distance of the MFG cluster from the TMS coil (the depth of the functional cluster).
Positive_regulation (stimulating) of MFG associated with transcranial magnetic stimulation
3) Confidence 0.08 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2789405 Disease Relevance 0 Pain Relevance 0.28
There were three TMS sessions, involving stimulation of PPC, MFG, or SHAM stimulation.
Positive_regulation (stimulation) of MFG associated with transcranial magnetic stimulation
4) Confidence 0.08 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2789405 Disease Relevance 0 Pain Relevance 0.10
In contrast, the main effect of the familiarity factor [partner's faces>unknown faces] was associated with activation of the right inferior frontal gyrus (BA9), the right medial prefrontal cortex (BA10) and the left posterior cingulate cortex (BA31) (p<0.001 uncorrected) (Table 2).
Positive_regulation (activation) of BA10 in cortex
5) Confidence 0.07 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3002948 Disease Relevance 0.77 Pain Relevance 0.74
In contrast, the main effect of the familiarity factor [partner's faces>unknown faces] was associated with activation of the right inferior frontal gyrus (BA9), the right medial prefrontal cortex (BA10) and the left posterior cingulate cortex (BA31) (p<0.001 uncorrected) (Table 2).
Positive_regulation (activation) of BA9 in cortex
6) Confidence 0.07 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3002948 Disease Relevance 0.76 Pain Relevance 0.73
These are two separate findings that both do not corroborate a MFG?
Neg (not) Positive_regulation (corroborate) of MFG
7) Confidence 0.06 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2789405 Disease Relevance 0 Pain Relevance 0.21
On the other hand, the selective response of vegans to animals in the ACC (with reduced amygdala responses) might reflect a greater attribution of self-relevance [13] and a greater recruitment of emotional regulation mechanisms [15], [26] when viewing negative states of non-human beings, together with an enhanced activation of the motor MNS and inhibitory control processes mediated through the MFG and the IFG, respectively.
Positive_regulation (activation) of MFG in amygdala associated with amygdala and anterior cingulate cortex
8) Confidence 0.06 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2877098 Disease Relevance 0.15 Pain Relevance 0.36
Importantly, this finding is still not corroborated by the fMRI EC result of MFG?
Positive_regulation (result) of MFG
9) Confidence 0.06 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2789405 Disease Relevance 0 Pain Relevance 0.21
Targeting this seeded PPC and the connected MFG with TMS in distinct time windows resulted in time-specific behavioral effects for both brain regions.
Positive_regulation (Targeting) of MFG in brain associated with transcranial magnetic stimulation
10) Confidence 0.06 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2789405 Disease Relevance 0 Pain Relevance 0.43
Real EAS specifically increased the pain-specific activation in bilateral secondary somatosensory area, medial prefrontal cortex, and Brodmann area (BA) 32, while it decreased the activation in contralateral primary somatosensory area, BA7, and BA24.
Positive_regulation (activation) of BA7 in prefrontal associated with pain
11) Confidence 0.03 Published 2003 Journal Neuroreport Section Abstract Doc Link 14502082 Disease Relevance 0.25 Pain Relevance 0.48
Comparisons of the patient's rCBF in the painful condition with that in the painless condition revealed significant rCBF increases in the left rectus gyrus (BA11), left superior frontal lobe (BA9), left anterior cingulate gyms (BA32), and the left thalamus (p < 0.05, corrected).
Positive_regulation (increases) of BA11 in lobe associated with pain, thalamus and anterior cingulate
12) Confidence 0.02 Published 2004 Journal J. Neurosurg. Section Abstract Doc Link 15137612 Disease Relevance 0.59 Pain Relevance 0.94
A subset of the TMS/hd-EEG sessions recorded on day1 (intensity I% and direction 0°) was compared with identical sessions accurately replicated on day8, namely stimulation of BA6 in 4 subjects, of BA7 in 7 subjects and of BA19 in 9 subjects.
Positive_regulation (stimulation) of BA6 associated with transcranial magnetic stimulation
13) Confidence 0.00 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2858649 Disease Relevance 0 Pain Relevance 0.17
A subset of the TMS/hd-EEG sessions recorded on day1 (intensity I% and direction 0°) was compared with identical sessions accurately replicated on day8, namely stimulation of BA6 in 4 subjects, of BA7 in 7 subjects and of BA19 in 9 subjects.
Positive_regulation (stimulation) of BA7 associated with transcranial magnetic stimulation
14) Confidence 0.00 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2858649 Disease Relevance 0 Pain Relevance 0.17

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