INT113268

Context Info Confidence 0.15 First Reported 2003 Last Reported 2009 Negated 0 Speculated 0 Reported most in Abstract Documents 3 Total Number 3 Disease Relevance 3.23 Pain Relevance 1.43

aging (Timp1) extracellular region (Timp1) proteinaceous extracellular matrix (Timp1)

Anatomy Link Frequency cerebrospinal fluid 2 Timp1 (Rattus norvegicus)

Pain Link Frequency Relevance Heat headache 3 100.00 metalloproteinase 28 97.52 Central nervous system 1 94.72 carpal tunnel syndrome 2 94.60 Inflammation 3 93.28 Multiple sclerosis 3 84.44

Disease Link Frequency Relevance Heat Contracture 8 99.98 Dupuytren's Disease 16 99.70 Disease 14 98.16 Carpal Tunnel Syndrome 2 94.60 INFLAMMATION 3 93.28 Headache 1 86.28 Demyelinating Disease 3 84.44 Neurological Disease 3 82.52 Fibrosis 2 66.84 Fibroma 6 62.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Patients with Dupuytren's contracture presented with a TIMP-1 concentration of 437 +/- 160 ng/ml, a significantly higher TIMP-1 concentration than that seen in the control patients, who had a concentration of 321 +/- 70 ng/ml (p < 0.05).

Positive_regulation (presented) of Positive_regulation (concentration) of TIMP-1 associated with dupuytren's disease and contracture

1) Confidence 0.15 Published 2003 Journal Plast. Reconstr. Surg. Section Abstract Doc Link 14504511 Disease Relevance 1.19 Pain Relevance 0.28

Patients with Dupuytren's contracture presented with a TIMP-1 concentration of 437 +/- 160 ng/ml, a significantly higher TIMP-1 concentration than that seen in the control patients, who had a concentration of 321 +/- 70 ng/ml (p < 0.05).

Positive_regulation (presented) of Positive_regulation (concentration) of TIMP-1 associated with dupuytren's disease and contracture

2) Confidence 0.15 Published 2003 Journal Plast. Reconstr. Surg. Section Abstract Doc Link 14504511 Disease Relevance 1.21 Pain Relevance 0.28

Elevated levels of MMP-9 and TIMP-1 in the cerebrospinal fluid of neuro-Behçet's disease.

Positive_regulation (Elevated) of Positive_regulation (levels) of TIMP-1 in cerebrospinal fluid associated with headache and disease

3) Confidence 0.07 Published 2009 Journal Clin. Exp. Rheumatol. Section Title Doc Link 19796534 Disease Relevance 0.83 Pain Relevance 0.87

General Comments

This test has worked.