INT113277

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Context Info
Confidence 0.69
First Reported 2003
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 13
Total Number 13
Disease Relevance 10.23
Pain Relevance 2.97

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (CYP19A1) small molecule metabolic process (CYP19A1) endoplasmic reticulum (CYP19A1)
cytoplasm (CYP19A1)
Anatomy Link Frequency
peritoneal fluid 2
PGE2 2
CYP19A1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 35 95.52 Very High Very High Very High
cINOD 89 94.68 High High
endometriosis 26 94.16 High High
Inflammatory response 6 91.20 High High
rheumatoid arthritis 68 90.56 High High
Osteoarthritis 49 90.00 High High
Pain 5 89.16 High High
aspirin 32 66.60 Quite High
metalloproteinase 74 50.00 Quite Low
Leflunomide 5 48.20 Quite Low
Disease Link Frequency Relevance Heat
Endometriosis 32 99.58 Very High Very High Very High
Breast Cancer 207 99.48 Very High Very High Very High
Cancer 118 96.32 Very High Very High Very High
INFLAMMATION 51 95.52 Very High Very High Very High
Disease 28 95.24 Very High Very High Very High
Apoptosis 10 94.96 High High
Rheumatoid Arthritis 68 90.56 High High
Obesity 2 90.48 High High
Frailty 50 90.00 High High
Pain 5 89.16 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Our hypothesis is that higher levels of COX expression result in higher levels of prostaglandin E2 (PGE2), which in turn increases CYP19 expression through increases in intracellular cyclic AMP levels.
Positive_regulation (increases) of Gene_expression (expression) of CYP19
1) Confidence 0.69 Published 2005 Journal J. Steroid Biochem. Mol. Biol. Section Abstract Doc Link 15964185 Disease Relevance 0.47 Pain Relevance 0.31
Aromatase overexpression has recently been detected in endometriotic tissue.
Positive_regulation (overexpression) of Gene_expression (overexpression) of Aromatase associated with endometriosis
2) Confidence 0.69 Published 2005 Journal Eur. J. Obstet. Gynecol. Reprod. Biol. Section Abstract Doc Link 16157442 Disease Relevance 0.59 Pain Relevance 0.25
Recently, aromatase overexpression has been detected in endometriotic tissue.
Positive_regulation (overexpression) of Gene_expression (overexpression) of aromatase associated with endometriosis
3) Confidence 0.69 Published 2003 Journal Zentralbl Gynakol Section Abstract Doc Link 14505258 Disease Relevance 0.59 Pain Relevance 0.25
Endometriotic lesions demonstrate increased aromatase expression in association with increased cyclo-oxygenase-2 expression, especially in red lesions which represent earlier stages of inflammation.
Positive_regulation (increased) of Gene_expression (expression) of aromatase associated with endometriosis and inflammation
4) Confidence 0.62 Published 2009 Journal Minerva Ginecol Section Abstract Doc Link 19745796 Disease Relevance 1.02 Pain Relevance 0.33
Aromatase expression, a possible intrinsic survival factor for endometrial tissue, is inducible in human endometrial fragments by androstenedione at physiological concentrations found in peritoneal fluid.
Positive_regulation (inducible) of Gene_expression (expression) of Aromatase in peritoneal fluid
5) Confidence 0.62 Published 2009 Journal Minerva Ginecol Section Abstract Doc Link 19745796 Disease Relevance 1.31 Pain Relevance 0.44
Furthermore, androgens can also increase aromatase gene expression [24].
Positive_regulation (increase) of Gene_expression (expression) of aromatase gene
6) Confidence 0.45 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1257423 Disease Relevance 0.57 Pain Relevance 0.29
Thus, PGE2 produced by COX enzymes may act locally in paracrine and autocrine fashion to increase the biosynthesis of estrogen by aromatase in hormone-dependent breast cancer development.
Positive_regulation (increase) of Gene_expression (biosynthesis) of aromatase in PGE2 associated with breast cancer
7) Confidence 0.13 Published 2006 Journal Minerva Endocrinol. Section Abstract Doc Link 16498361 Disease Relevance 0.65 Pain Relevance 0.22
Aromatase transcript expression and enzyme activity in breast tumor tissue is greater than that in the normal breast tissue, and prostaglandins can increase CYP19 expression and aromatase activity in breast cancer cells.
Positive_regulation (increase) of Gene_expression (expression) of aromatase associated with breast cancer
8) Confidence 0.13 Published 2006 Journal Minerva Endocrinol. Section Abstract Doc Link 16498361 Disease Relevance 0.55 Pain Relevance 0.20
Aromatase transcript expression and activity in breast tumor tissue is greater than that in the normal breast tissue, and prostaglandins can increase CYP19 expression and aromatase activity in breast cancer cells.
Positive_regulation (increase) of Gene_expression (expression) of aromatase associated with breast cancer
9) Confidence 0.12 Published 2006 Journal Anti-cancer agents in medicinal chemistry Section Abstract Doc Link 16712450 Disease Relevance 0.95 Pain Relevance 0.13
Thus, PGE(2) produced via COX may act locally in paracrine and autocrine fashion to increase the biosynthesis of estrogen by aromatase in hormone-dependent breast cancer development.
Positive_regulation (increase) of Gene_expression (biosynthesis) of aromatase associated with breast cancer
10) Confidence 0.12 Published 2006 Journal Anti-cancer agents in medicinal chemistry Section Abstract Doc Link 16712450 Disease Relevance 0.60 Pain Relevance 0.15
In breast cancer PGs, particularly PGE2, have an organ-site-specific effect of increasing the levels of aromatase, thereby increasing estrogen and progesterone synthesis [10-12].
Positive_regulation (increasing) of Gene_expression (levels) of aromatase associated with breast cancer
11) Confidence 0.10 Published 2006 Journal Breast Cancer Res Section Body Doc Link PMC1797023 Disease Relevance 1.12 Pain Relevance 0.32
The ability of COX-derived PGs to increase aromatase expression and hence local estrogen levels may provide a partial explanation for reports of reduced incidence of breast cancer associated with NSAID use [5-12], because COX inhibition is predicted to decrease mammary estrogen levels and hence restrict the growth of estrogen-dependent tumors.
Positive_regulation (increase) of Gene_expression (expression) of aromatase associated with cancer, breast cancer and cinod
12) Confidence 0.07 Published 2007 Journal Breast Cancer Res Section Body Doc Link PMC2206709 Disease Relevance 0.84 Pain Relevance 0.09
PGE2 was shown to stimulate cell proliferation indirectly by increasing estrogen levels via the induction of the aromatase gene expression [9].
Positive_regulation (induction) of Gene_expression (expression) of aromatase gene
13) Confidence 0.01 Published 2006 Journal BMC Cancer Section Body Doc Link PMC1559713 Disease Relevance 0.96 Pain Relevance 0

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