INT113279

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Context Info
Confidence 0.24
First Reported 2003
Last Reported 2006
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 4
Disease Relevance 3.65
Pain Relevance 1.59

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

oxidoreductase activity (HSD17B2)
Anatomy Link Frequency
stromal cells 1
epithelial cells 1
HSD17B2 (Homo sapiens)
Pain Link Frequency Relevance Heat
endometriosis 30 99.48 Very High Very High Very High
pain pelvic 4 72.04 Quite High
Pain 4 70.44 Quite High
Inflammation 4 68.92 Quite High
COX-2 inhibitor 2 54.00 Quite High
COX2 1 25.00 Low Low
Disease Link Frequency Relevance Heat
Endometriosis 40 99.48 Very High Very High Very High
Apoptosis 2 73.68 Quite High
Reprotox - General 3 4 72.04 Quite High
Disease 2 71.28 Quite High
Pain 4 70.44 Quite High
INFLAMMATION 4 68.92 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Another abnormality in endometriosis, i. e. the deficiency in 17 beta-hydroxysteroiddehydrogenase type-II (17 beta-HSD-Type-II) expression, impairs the inactivation of estradiol to estrone.
Gene_expression (expression) of 17 beta-hydroxysteroiddehydrogenase type-II associated with endometriosis
1) Confidence 0.24 Published 2003 Journal Zentralbl Gynakol Section Abstract Doc Link 14505258 Disease Relevance 0.69 Pain Relevance 0.29
Another abnormality in endometriosis, the deficient 17beta-hydroxysteroiddehydrogenase type II (17beta-HSD-Type-II) expression, impairs the inactivation of estradiol to estrone.
Gene_expression (expression) of 17beta-HSD-Type-II associated with endometriosis
2) Confidence 0.14 Published 2005 Journal Eur. J. Obstet. Gynecol. Reprod. Biol. Section Abstract Doc Link 16157442 Disease Relevance 0.69 Pain Relevance 0.29
In endometriotic tissue, progesterone does not induce epithelial 17beta-HSD-2 expression due to a defect in stromal cells.
Gene_expression (expression) of 17beta-HSD-2 in stromal cells associated with endometriosis
3) Confidence 0.02 Published 2006 Journal Mol. Cell. Endocrinol. Section Abstract Doc Link 16406281 Disease Relevance 1.06 Pain Relevance 0.46
These unknown factor(s) act on neighboring epithelial cells to induce the expression of the enzyme 17beta-hydroxysteroid dehydrogenase type 2 (17beta-HSD-2), which metabolizes the biologically active estrogen E2 to estrone (E1).
Gene_expression (expression) of 17beta-HSD-2 in epithelial cells
4) Confidence 0.02 Published 2006 Journal Mol. Cell. Endocrinol. Section Abstract Doc Link 16406281 Disease Relevance 1.21 Pain Relevance 0.55

General Comments

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