INT113283

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Context Info
Confidence 0.41
First Reported 2003
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.40
Pain Relevance 0.35

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Tyms) methyltransferase activity (Tyms) mRNA binding (Tyms)
nucleolus (Tyms) nucleus (Tyms) cytoplasm (Tyms)
Anatomy Link Frequency
uterine 1
Tyms (Mus musculus)
Pain Link Frequency Relevance Heat
methotrexate 70 87.32 High High
Glutamate 2 73.16 Quite High
adenocard 8 57.76 Quite High
antagonist 2 57.68 Quite High
Inflammation 2 51.84 Quite High
Arthritis 27 50.00 Quite Low
Dismenorea 2 50.00 Quite Low
Pain 1 5.00 Very Low Very Low Very Low
Bioavailability 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Death 1 79.92 Quite High
Cancer 2 79.20 Quite High
Dysmenorrhea 2 69.20 Quite High
Rheumatoid Arthritis 11 69.04 Quite High
INFLAMMATION 2 51.84 Quite High
Toxicity 22 51.36 Quite High
Juvenile Chronic Polyarthritis 23 50.00 Quite Low
Body Weight 1 45.76 Quite Low
Rheumatic Diseases 1 12.60 Low Low
Disease 11 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Inhibition of thymidylate synthetase (TYMS), both directly and indirectly via depletion of tetrahydrofolate, leads to inhibition of pyrimidine biosynthesis with a resultant antiproliferative effect [30].
Negative_regulation (Inhibition) of TYMS
1) Confidence 0.41 Published 2010 Journal Human Genomics and Proteomics : HGP Section Body Doc Link PMC2958653 Disease Relevance 0.33 Pain Relevance 0.35
The number of bromodeoxyuridine immunoreactive cells and activities of thymidylate synthase and thymidine kinase in uterine tissues were markedly reduced in TNP-470-treated mice.
Negative_regulation (reduced) of thymidylate synthase in uterine
2) Confidence 0.22 Published 2003 Journal Fertil. Steril. Section Body Doc Link 14505755 Disease Relevance 0.07 Pain Relevance 0

General Comments

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