INT113317

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Context Info
Confidence 0.52
First Reported 2003
Last Reported 2010
Negated 2
Speculated 4
Reported most in Body
Documents 17
Total Number 20
Disease Relevance 10.27
Pain Relevance 10.68

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Cnr2) signal transducer activity (Cnr2)
Anatomy Link Frequency
brain 2
dorsal root ganglia 2
immune cells 1
spinal cord 1
neurons 1
Cnr2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Cannabinoid 88 100.00 Very High Very High Very High
Cannabinoid receptor 79 100.00 Very High Very High Very High
Analgesic 35 99.98 Very High Very High Very High
cannabis 16 99.98 Very High Very High Very High
Antinociceptive 16 99.98 Very High Very High Very High
qutenza 15 99.78 Very High Very High Very High
agonist 104 99.60 Very High Very High Very High
Endocannabinoid 144 99.52 Very High Very High Very High
Inflammation 44 99.32 Very High Very High Very High
antagonist 46 99.08 Very High Very High Very High
Disease Link Frequency Relevance Heat
Neuropathic Pain 151 99.72 Very High Very High Very High
Cannabis Dependence 1 99.60 Very High Very High Very High
INFLAMMATION 40 99.32 Very High Very High Very High
Cirrhosis 61 98.66 Very High Very High Very High
Cv Unclassified Under Development 4 98.40 Very High Very High Very High
Irritable Bowel Syndrome /

Irritable Bowel Syndrome Super

4 96.96 Very High Very High Very High
Targeted Disruption 11 96.88 Very High Very High Very High
Pain 79 96.28 Very High Very High Very High
Hyperalgesia 15 93.28 High High
Colitis 4 92.88 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These functional data are supported by studies demonstrating an up-regulation of CB2 receptor mRNA and/or protein in the ipsilateral spinal cord [7-9] and ipsilateral dorsal horn [10] of neuropathic rats, compared to sham-operated rats.
Regulation (regulation) of CB2 receptor in spinal cord associated with neuropathic pain, dorsal horn and spinal cord
1) Confidence 0.52 Published 2009 Journal Mol Pain Section Body Doc Link PMC2719614 Disease Relevance 0.92 Pain Relevance 1.14
Effects of the CB2 receptor agonist, JWH-133, and the CB1 receptor agonist, arachidonyl-2-chloroethylamide (ACEA), on primary afferent fibres were determined by calcium imaging studies of adult dorsal root ganglion (DRG) neurons taken from neuropathic and sham-operated rats.
Regulation (Effects) of CB2 in dorsal root ganglion associated with ganglion cysts, dorsal root ganglion, primary afferent fibers, neuropathic pain, agonist and imagery
2) Confidence 0.45 Published 2005 Journal Eur. J. Neurosci. Section Abstract Doc Link 16045490 Disease Relevance 0.82 Pain Relevance 0.79
The effects of CB1 and CB2 receptor agonists and antagonists on the abdominal contractile response to colorectal distension (CRD) in basal conditions and after 2,4,6-trinitrobenzenesulphonic acid-induced colitis were investigated.
Spec (investigated) Regulation (effects) of CB2 associated with colitis, antagonist and agonist
3) Confidence 0.44 Published 2006 Journal Neurogastroenterol. Motil. Section Abstract Doc Link 16961698 Disease Relevance 0.90 Pain Relevance 0.52
The combination of anandamide with ibuprofen produced synergistic antinociceptive effects involving both cannabinoid CB1 and CB2 receptors.
Regulation (effects) of CB2 associated with cannabinoid and antinociceptive
4) Confidence 0.37 Published 2006 Journal Pain Section Abstract Doc Link 16480822 Disease Relevance 0.25 Pain Relevance 0.61
Evidence of the analgesic effect of CB2 selective agonists has been obtained in various models of both inflammatory and neuropathic chronic pain.
Regulation (effect) of CB2 associated with inflammation, lasting pain, analgesic, neuropathic pain and agonist
5) Confidence 0.35 Published 2009 Journal J. Soc. Biol. Section Abstract Doc Link 19358815 Disease Relevance 0.94 Pain Relevance 1.23
In contrast to CB1, there were no statistically significant differences in the protein levels for CB2 (Figure 2A, C).
Neg (no) Regulation (differences) of CB2
6) Confidence 0.34 Published 2009 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2775033 Disease Relevance 0 Pain Relevance 0
The smooth muscle cells of blood vessels exhibited immunopositivity for CB1 and CB2 (data not shown).
Regulation (immunopositivity) of CB2 in smooth muscle cells
7) Confidence 0.34 Published 2009 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2775033 Disease Relevance 0 Pain Relevance 0.04
Homogenates of brain and spleen were used as positive controls for CB1, TRPV1 and CB2, respectively.
Regulation (controls) of CB2 in spleen
8) Confidence 0.34 Published 2009 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2775033 Disease Relevance 0 Pain Relevance 0
In addition, several genes such as BCL6, BTK and CNR2 that may modulate release of eicosanoids [20-22] are also reduced in the ipsilateral DRGs four days after CFA treatment.
Spec (may) Regulation (modulate) of CNR2
9) Confidence 0.34 Published 2010 Journal Mol Pain Section Body Doc Link PMC2949723 Disease Relevance 0.54 Pain Relevance 0.55
This can also explain the difficulty faced by researchers engaged in investigating the role of CB1 and CB2 receptors using pharmacological antagonists and agonists.
Spec (investigating) Regulation (role) of CB2 associated with antagonist and agonist
10) Confidence 0.29 Published 2010 Journal Indian Journal of Urology : IJU : Journal of the Urological Society of India Section Body Doc Link PMC2878434 Disease Relevance 1.02 Pain Relevance 1.06
Indole ring substitutions had varying effects on CB 2 and CB 1 binding, but were generally detrimental to agonist activity.
Regulation (effects) of CB 2 associated with agonist
11) Confidence 0.27 Published 2008 Journal J. Med. Chem. Section Abstract Doc Link 18311894 Disease Relevance 0 Pain Relevance 0.30
The CB2 receptor is an attractive therapeutic target for analgesic and anti-inflammatory agents.
Regulation (target) of CB2 associated with inflammation and analgesic
12) Confidence 0.27 Published 2008 Journal J. Med. Chem. Section Abstract Doc Link 18680277 Disease Relevance 0.10 Pain Relevance 0.37
One of the perceived benefits of targeting the CB2 receptor for novel analgesics was the purported absence of receptor in the brain and therefore the lack of the psychoactive side-effects (Malan et al., 2003) which limit the clinical usefulness of CB1 receptor agonists.
Regulation (targeting) of CB2 receptor in brain associated with analgesic and agonist
13) Confidence 0.27 Published 2008 Journal The European Journal of Neuroscience Section Body Doc Link PMC2327204 Disease Relevance 0.45 Pain Relevance 0.56
Little or no cannabinoid receptor 2 immunoreactivity was found in sections of naive rat or mouse dorsal root ganglia or spinal cord.
Neg (no) Regulation (immunoreactivity) of cannabinoid receptor 2 in dorsal root ganglia associated with cannabinoid receptor and spinal cord
14) Confidence 0.27 Published 2005 Journal Neuroscience Section Abstract Doc Link 16084654 Disease Relevance 0.29 Pain Relevance 0.56
These results suggest that peripheral CB2 receptors may be an appropriate target for eliciting relief of inflammatory pain without the CNS effects of nonselective cannabinoid receptor agonists.


Regulation (target) of CB2 in CNS
15) Confidence 0.26 Published 2003 Journal Anesthesiology Section Body Doc Link 14508331 Disease Relevance 0.11 Pain Relevance 0
Inhibitory effects of CB1 and CB2 receptor agonists on responses of DRG neurons and dorsal horn neurons in neuropathic rats.
Regulation (effects) of CB2 in neurons associated with cannabinoid, neuropathic pain, agonist and dorsal horn neuron
16) Confidence 0.20 Published 2005 Journal Eur. J. Neurosci. Section Title Doc Link 16045490 Disease Relevance 0.77 Pain Relevance 0.94
Other agents that are thought to play a role in the peripheral vasodilatation of cirrhosis include endocannabinoids.[20] They are lipid-like substances that act on two inhibitory G protein-coupled receptors, CB1 and CB2.
Spec (like) Regulation (act) of CB2 associated with endocannabinoid, cirrhosis and cv unclassified under development
17) Confidence 0.17 Published 2010 Journal Saudi Journal of Gastroenterology : Official Journal of the Saudi Gastroenterology Association Section Body Doc Link PMC3003209 Disease Relevance 0.89 Pain Relevance 0.22
Homogenates of brain and spleen were used as positive controls for CB1, TRPV1 and CB2, respectively.
Regulation (controls) of CB2 in brain
18) Confidence 0.12 Published 2009 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2775033 Disease Relevance 0 Pain Relevance 0
Cannabis acts on the CB1 (central) and CB2 (on immune cells) cannabinoid receptors.
Regulation (acts) of CB2 in immune cells associated with cannabis and cannabinoid receptor
19) Confidence 0.08 Published 2007 Journal Indian Journal of Psychiatry Section Body Doc Link PMC2917090 Disease Relevance 0.67 Pain Relevance 1.39
The ABHD12 enzyme was recently shown to hydrolyze 2-arachidonoyl glycerol (2-AG), the main endocannabinoid lipid transmitter that acts on cannabinoid receptors CB1 and CB2.
Regulation (acts) of CB2 associated with endocannabinoid and cannabinoid receptor
20) Confidence 0.05 Published 2010 Journal Am. J. Hum. Genet. Section Abstract Doc Link 20797687 Disease Relevance 1.25 Pain Relevance 0.39

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