INT113327

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Context Info
Confidence 0.41
First Reported 2003
Last Reported 2003
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 0.60
Pain Relevance 0.09

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Dmbt1) extracellular region (Dmbt1) proteinaceous extracellular matrix (Dmbt1)
intracellular (Dmbt1) molecular_function (Dmbt1) cytoplasm (Dmbt1)
Anatomy Link Frequency
brain 2
Dmbt1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
IPN 3 90.24 High High
Disease Link Frequency Relevance Heat
Malignant Neoplastic Disease 3 100.00 Very High Very High Very High
Brain Tumor 3 100.00 Very High Very High Very High
Cholangiocarcinoma 6 98.36 Very High Very High Very High
Cancer 6 95.32 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The homozygous deletion of the DMBT-1 gene was recognized in four (20%) of 20 cholangiocarcinoma tissues and two (50%) of four cholangiocarcinoma cell lines, corresponding to the reduction of DMBT-1 expression.
Negative_regulation (reduction) of Gene_expression (expression) of DMBT-1
1) Confidence 0.41 Published 2003 Journal Histopathology Section Body Doc Link 14511252 Disease Relevance 0.06 Pain Relevance 0
Decreased expression of DMBT-1 and homozygous deletion of the DMBT-1 gene in invasive cholangiocarcinoma suggest that they occur in the late stage of cholangiocarcinogenesis.


Negative_regulation (Decreased) of Gene_expression (expression) of DMBT-1
2) Confidence 0.41 Published 2003 Journal Histopathology Section Body Doc Link 14511252 Disease Relevance 0.05 Pain Relevance 0
Decrease of deleted in malignant brain tumour-1 (DMBT-1) expression is a crucial late event in intrahepatic cholangiocarcinoma.
Negative_regulation (Decrease) of Gene_expression (expression) of DMBT-1 in brain associated with malignant neoplastic disease, cholangiocarcinoma and brain tumor
3) Confidence 0.40 Published 2003 Journal Histopathology Section Title Doc Link 14511252 Disease Relevance 0.49 Pain Relevance 0.09

General Comments

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