INT113339

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.40
First Reported 2003
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 6
Total Number 6
Disease Relevance 5.31
Pain Relevance 2.40

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (JAK2) cytosol (JAK2) signal transduction (JAK2)
histone binding (JAK2) cytoskeleton (JAK2) nucleus (JAK2)
Anatomy Link Frequency
neuronal 1
cardiomyocytes 1
glial cells 1
neurons 1
JAK2 (Homo sapiens)
Pain Link Frequency Relevance Heat
allodynia 3 87.24 High High
dorsal root ganglion 15 78.96 Quite High
Pain 21 75.52 Quite High
Peripheral nerve injury 3 75.00 Quite High
cytokine 12 68.64 Quite High
Neuropathic pain 3 66.48 Quite High
Peripheral nervous system 3 61.80 Quite High
Central nervous system 3 56.28 Quite High
Opioid 6 5.00 Very Low Very Low Very Low
drug abuse 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 24 95.04 Very High Very High Very High
Hepatitis C Virus Infection 117 91.16 High High
Neuropathic Pain 6 87.24 High High
Ganglion Cysts 15 78.96 Quite High
Pain 12 75.52 Quite High
Nervous System Injury 3 75.00 Quite High
Opiate Addiction 79 74.96 Quite High
Infection 65 72.24 Quite High
Non-diabetic Peripheral Neuropathy 3 65.84 Quite High
Injury 4 58.08 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The receptor does not possess any kinase activity, but its intracellular region binds to JAK2 tyrosine kinase that is essential for EPO signaling.
JAK2 Binding (binds) of
1) Confidence 0.40 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2916842 Disease Relevance 0 Pain Relevance 0.06
Dual immunofluorescence demonstrated Epo-induced JAK2-p was associated with both neuronal and glial cells.
JAK2-p Binding (associated) of in neuronal
2) Confidence 0.34 Published 2003 Journal Eur. J. Neurosci. Section Abstract Doc Link 14511329 Disease Relevance 1.40 Pain Relevance 0.78
JAK2-p was associated with NF200-positive large neurons and with smaller neurons.
JAK2-p Binding (associated) of in neurons
3) Confidence 0.34 Published 2003 Journal Eur. J. Neurosci. Section Abstract Doc Link 14511329 Disease Relevance 1.38 Pain Relevance 0.78
The binding brings the associated Jaks (Jak2 and Tyk2) phosphorylation and the activated signals are then transduced to STATs, which become phosphorylated and form dimers (Fig. 9).
Jak2 Binding (associated) of
4) Confidence 0.22 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2834757 Disease Relevance 1.13 Pain Relevance 0
Dual immunofluorescence demonstrated Epo-induced JAK2-p was associated with both neuronal and glial cells.
JAK2-p Binding (associated) of in glial cells
5) Confidence 0.12 Published 2003 Journal Eur. J. Neurosci. Section Abstract Doc Link 14511329 Disease Relevance 1.40 Pain Relevance 0.78
However, neither RVPO nor RGD stimulation of adult cardiomyocytes exhibited JAK2 recruitment or phosphorylation.
JAK2 Binding (recruitment) of in cardiomyocytes
6) Confidence 0.08 Published 2008 Journal International Journal of Biological Sciences Section Body Doc Link PMC2443357 Disease Relevance 0 Pain Relevance 0

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox