INT113340

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Context Info
Confidence 0.78
First Reported 2003
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 17
Total Number 18
Disease Relevance 5.69
Pain Relevance 1.60

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (JAK2) cytosol (JAK2) signal transduction (JAK2)
histone binding (JAK2) cytoskeleton (JAK2) nucleus (JAK2)
Anatomy Link Frequency
cardiomyocytes 3
endothelial cell 1
nucleus 1
JAK2 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 107 96.80 Very High Very High Very High
allodynia 1 93.88 High High
Inflammation 103 91.52 High High
Inflammatory mediators 3 87.76 High High
fibrosis 6 80.48 Quite High
dorsal root ganglion 5 79.48 Quite High
antagonist 19 78.40 Quite High
Pain 12 77.92 Quite High
Peripheral nerve injury 1 75.00 Quite High
Peripheral nervous system 1 68.44 Quite High
Disease Link Frequency Relevance Heat
Apoptosis 125 99.48 Very High Very High Very High
Coronary Artery Disease 76 97.94 Very High Very High Very High
Atherosclerosis 69 94.48 High High
Neuropathic Pain 3 93.88 High High
Necrosis 9 93.52 High High
INFLAMMATION 121 91.52 High High
Leiomyosarcoma 59 91.40 High High
Hepatitis C Virus Infection 117 90.48 High High
Diabetes Mellitus 49 83.36 Quite High
Fibrosis 7 80.48 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Systemic rhEpo therapy increased JAK2 phosphorylation, a key anti-apoptotic signalling molecule for Epo-induced neuroprotection, in DRGs after crush.
Phosphorylation (phosphorylation) of JAK2 associated with apoptosis
1) Confidence 0.78 Published 2003 Journal Eur. J. Neurosci. Section Abstract Doc Link 14511329 Disease Relevance 1.43 Pain Relevance 0.72
In turn, activated JAK2 (in concert with other kinases) phosphorylates eight conserved tyrosines in cytoplasmic domain [4].
Phosphorylation (phosphorylates) of JAK2
2) Confidence 0.68 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2916842 Disease Relevance 0 Pain Relevance 0.03
EPOR engagement stimulates JAK2 phosphorylation at Y1007/1008 residues [3].
Phosphorylation (phosphorylation) of JAK2
3) Confidence 0.68 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2916842 Disease Relevance 0 Pain Relevance 0.06
Both the receptor and JAK2 protein are phosphorylated, and signal transducers and activators of transcription (STAT) proteins bind to this complex.
Phosphorylation (phosphorylated) of JAK2 protein
4) Confidence 0.65 Published 2008 Journal Vascular Health and Risk Management Section Body Doc Link PMC2663454 Disease Relevance 0.06 Pain Relevance 0.04
JAK2 and STAT3 phosphorylated and total protein was measured using western blotting techniques.
Phosphorylation (phosphorylated) of JAK2
5) Confidence 0.49 Published 2009 Journal PLoS ONE Section Abstract Doc Link PMC2696599 Disease Relevance 0.15 Pain Relevance 0.05
, JAK2 is phosphorylated and initiates the phosphorylation of STAT3.
Phosphorylation (phosphorylated) of JAK2
6) Confidence 0.49 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2696599 Disease Relevance 0 Pain Relevance 0
EPC from CAD patients were shown to have a reduced revascularization capacity, with diminished CXCR4 signaling, as Jak2 phosphorylation by CXCL12 is impaired, compared to EPC from healthy individuals, while the expression levels of CXCR4 are normal [24].
Phosphorylation (phosphorylation) of Jak2 associated with coronary artery disease
7) Confidence 0.38 Published 2010 Journal BMC Genomics Section Body Doc Link PMC2901320 Disease Relevance 0.41 Pain Relevance 0
The binding brings the associated Jaks (Jak2 and Tyk2) phosphorylation and the activated signals are then transduced to STATs, which become phosphorylated and form dimers (Fig. 9).
Phosphorylation (phosphorylation) of Jak2
8) Confidence 0.38 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2834757 Disease Relevance 1.08 Pain Relevance 0
to the type II IFN receptor, JAK1 and JAK2 are activated and phosphorylate the signal transducer and activator of transcription 1(STAT1) on the tyrosine residue at position 701 (Tyr701) and the serine residue at position 727 (Ser727) (Parmar and Platanias, 2005; Platanias, 2005) (Fig. 2).
Phosphorylation (phosphorylate) of JAK2
9) Confidence 0.34 Published 2008 Journal Gene Regulation and Systems Biology Section Body Doc Link PMC2733082 Disease Relevance 0.56 Pain Relevance 0
Subsequently, the activated JAK2 phosphorylates the receptor and STATs (signal transducer and activator of transcription), and dimers of the latter are translocated to the nucleus to promote gene transcription (Carter-Su and Smit 1998).
Phosphorylation (phosphorylates) of JAK2 in nucleus
10) Confidence 0.25 Published 2006 Journal International Journal of Nanomedicine Section Body Doc Link PMC2676637 Disease Relevance 0 Pain Relevance 0.07
Cupric-ion-oxidized LDL (CuLDL) or endothelial cell-oxidized LDL (ELDL) induces the activation by Tyr-phosphorylation of JAK2, one of the Janus kinase involved upstream of STATs in the JAK/STAT pathway of cytokine transduction.
Phosphorylation (phosphorylation) of JAK2 in endothelial cell associated with cytokine
11) Confidence 0.22 Published 2007 Journal Immun Ageing Section Body Doc Link PMC1845171 Disease Relevance 0.60 Pain Relevance 0.05
blocks tyrosine phosphorylation of Jak2 and Lyn tyrosine kinases.139 Furthermore, it inhibits the activation of ERK MAP kinase and Stat1 nuclear factor.
Phosphorylation (phosphorylation) of Jak2
12) Confidence 0.22 Published 2010 Journal Allergy, Asthma & Immunology Research Section Body Doc Link PMC2846745 Disease Relevance 1.10 Pain Relevance 0.20
the phosphorylation of signal transducers and activators of transcription

(STAT) 1 and 3 as well as Janus kinase 1 (JAK1) and JAK2 in activated

Phosphorylation (phosphorylation) of JAK2
13) Confidence 0.20 Published 2008 Journal PPAR Research Section Body Doc Link PMC2367430 Disease Relevance 0.30 Pain Relevance 0.35
These experiments showed JAK2 phosphorylation upon EGF stimulation (Figure 2c), indicating the possibility that a JAK2-independent mechanism contributes to STAT3 phosphorylation/activation.


Phosphorylation (phosphorylation) of JAK2
14) Confidence 0.18 Published 2008 Journal International Journal of Biological Sciences Section Body Doc Link PMC2443357 Disease Relevance 0 Pain Relevance 0
Our analysis using in vivo and in vitro models of hypertrophic stimulation did not show JAK2 phosphorylation, though JAK2 phosphorylation/activation could be observed in EGF-treated adult feline cardiomyocytes in vitro.
Phosphorylation (phosphorylation) of JAK2 in cardiomyocytes
15) Confidence 0.18 Published 2008 Journal International Journal of Biological Sciences Section Body Doc Link PMC2443357 Disease Relevance 0 Pain Relevance 0.03
We confirmed our data using an additional commercially available antibody for the detection of JAK2 phosphorylation at Tyr1007/1008 sites (data not shown).
Phosphorylation (phosphorylation) of JAK2
16) Confidence 0.18 Published 2008 Journal International Journal of Biological Sciences Section Body Doc Link PMC2443357 Disease Relevance 0 Pain Relevance 0
To ascertain whether the classic JAK2-mediated pathway is involved during STAT3 activation, we assayed for JAK2 recruitment to the insoluble fraction and phosphorylation at Tyr1007/1008 sites at all time points of PO (Figure 2a) and RGD stimulation of cardiomyocytes (Figure 2b).
Phosphorylation (phosphorylation) of JAK2 in cardiomyocytes
17) Confidence 0.14 Published 2008 Journal International Journal of Biological Sciences Section Body Doc Link PMC2443357 Disease Relevance 0 Pain Relevance 0
However, neither RVPO nor RGD stimulation of adult cardiomyocytes exhibited JAK2 recruitment or phosphorylation.
Phosphorylation (phosphorylation) of JAK2 in cardiomyocytes
18) Confidence 0.14 Published 2008 Journal International Journal of Biological Sciences Section Body Doc Link PMC2443357 Disease Relevance 0 Pain Relevance 0

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