INT113342

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Context Info
Confidence 0.66
First Reported 2003
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 2.58
Pain Relevance 0.72

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (JAK2) cytosol (JAK2) signal transduction (JAK2)
histone binding (JAK2) cytoskeleton (JAK2) nucleus (JAK2)
JAK2 (Homo sapiens)
Pain Link Frequency Relevance Heat
allodynia 1 94.28 High High
dorsal root ganglion 5 79.88 Quite High
Pain 7 78.32 Quite High
Peripheral nerve injury 1 75.00 Quite High
Peripheral nervous system 1 68.84 Quite High
Central nervous system 1 63.32 Quite High
Neuropathic pain 1 48.48 Quite Low
Opioid 6 5.00 Very Low Very Low Very Low
cytokine 4 5.00 Very Low Very Low Very Low
drug abuse 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 7 99.48 Very High Very High Very High
Neuropathic Pain 2 94.28 High High
Hepatitis C Virus Infection 117 91.16 High High
Ganglion Cysts 5 79.88 Quite High
Pain 4 78.32 Quite High
Opiate Addiction 79 77.04 Quite High
Nervous System Injury 1 75.00 Quite High
Infection 64 74.32 Quite High
Non-diabetic Peripheral Neuropathy 1 72.88 Quite High
Injury 1 65.12 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Systemic rhEpo therapy increased JAK2 phosphorylation, a key anti-apoptotic signalling molecule for Epo-induced neuroprotection, in DRGs after crush.
Positive_regulation (increased) of Phosphorylation (phosphorylation) of JAK2 associated with apoptosis
1) Confidence 0.66 Published 2003 Journal Eur. J. Neurosci. Section Abstract Doc Link 14511329 Disease Relevance 1.44 Pain Relevance 0.72
The binding brings the associated Jaks (Jak2 and Tyk2) phosphorylation and the activated signals are then transduced to STATs, which become phosphorylated and form dimers (Fig. 9).
Positive_regulation (associated) of Phosphorylation (phosphorylation) of Jak2
2) Confidence 0.23 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2834757 Disease Relevance 1.14 Pain Relevance 0

General Comments

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