INT113345
From wiki-pain
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Sentences Mentioned In
Key: | Protein | Mutation | Event | Anatomy | Negation | Speculation | Pain term | Disease term |
Interestingly, capsaicin-sensitive leukemic cells were possessed of wild-type p53, resulting in the phosphorylation of p53 at the Ser-15 residue by the treatment of capsaicin. | |||||||||||||||
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Moreover, we observed that CPS activates ATM kinase that is involved in Ser15, Ser20 and Ser392 p53 phosphorylation as shown by the use of the specific inhibitor KU55933. | |||||||||||||||
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Here, we show that treatment of the human colon carcinoma cell line HCT116 with different concentrations of R-flurbiprofen leads to an accumulation of p53 protein which is accompanied by an increase in phosphorylated p53 at serine 15. | |||||||||||||||
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In the meanwhile, phosphorylation of p53 at serine 15, accumulation of p53 and increased the expression of its downstream target genes, p21 and Bax induced by ASA. | |||||||||||||||
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Indeed, phosphorylation of p53 activates the release of cytochrome c and caspase-9 via target genes such as Bax (BCL-2 [B-cell lymphoma-2] associated protein), Bak (BCL-2 homologous antagonist/killer), Noxa (damage), and PUMA (p53 upregulated modulator of apoptosis) [27]. | |||||||||||||||
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DNA damage can change phosphorylation levels of the p53 protein, resulting in cell cycle arrest and apoptosis [22,23]. | |||||||||||||||
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In addition, Okabe et al., demonstrated that FK228 treatment induces a diverse range of histone and non-histone protein acetylation in BCR-ABL transfected cell lines, including acetylation of p53, Hsp90 and BCR-ABL [81]. | |||||||||||||||
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Andrographolide induces apoptosis in human cancer cells via the activation of caspase 8, pro-apoptotic Bcl-2 family members Bax conformational change, release of cytochrome C from mitochondria and activation of caspase cascade [52] and/or via the activation of tumour suppressor p53 by ROS-dependent c-Jun NH2-terminal kinase (JNK) activation, thereby increasing p53 phosphorylation and protein stabilization [53,54]. | |||||||||||||||
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