INT113345

Context Info Confidence 0.66 First Reported 2003 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 8 Total Number 8 Disease Relevance 6.11 Pain Relevance 1.80

cell differentiation (TP53) nucleoplasm (TP53) mitochondrion (TP53) endoplasmic reticulum (TP53) enzyme binding (TP53) protein complex assembly (TP53)

Anatomy Link Frequency B-cell 2 colon 2 TP53 (Homo sapiens)

Pain Link Frequency Relevance Heat qutenza 22 99.40 antagonist 2 94.32 cINOD 3 77.12 Inflammation 48 76.64 agonist 1 70.64 aspirin 4 50.00 Potency 1 30.00 cytokine 24 28.08 COX2 1 10.00 chemokine 5 5.00

Disease Link Frequency Relevance Heat Apoptosis 94 98.52 Cancer 57 98.30 Colon Cancer 4 97.34 Lymphatic System Cancer 4 96.52 Epilepsy 1 95.04 Death 26 93.52 Myeloid Leukemia 25 92.72 Ataxia 1 87.16 Stress 28 85.64 Hepatocellular Cancer 2 81.92

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Interestingly, capsaicin-sensitive leukemic cells were possessed of wild-type p53, resulting in the phosphorylation of p53 at the Ser-15 residue by the treatment of capsaicin.

Positive_regulation (resulting) of Phosphorylation (phosphorylation) of p53 associated with qutenza

1) Confidence 0.66 Published 2004 Journal Cancer Res. Section Abstract Doc Link 14871840 Disease Relevance 0.65 Pain Relevance 1.12

Moreover, we observed that CPS activates ATM kinase that is involved in Ser15, Ser20 and Ser392 p53 phosphorylation as shown by the use of the specific inhibitor KU55933.

Positive_regulation (involved) of Phosphorylation (phosphorylation) of p53 associated with qutenza

2) Confidence 0.49 Published 2009 Journal Carcinogenesis Section Abstract Doc Link 19502594 Disease Relevance 0.93 Pain Relevance 0.52

Here, we show that treatment of the human colon carcinoma cell line HCT116 with different concentrations of R-flurbiprofen leads to an accumulation of p53 protein which is accompanied by an increase in phosphorylated p53 at serine 15.

Positive_regulation (increase) of Phosphorylation (phosphorylated) of p53 in colon associated with colon cancer

3) Confidence 0.46 Published 2005 Journal Biochem. Pharmacol. Section Abstract Doc Link 15710360 Disease Relevance 0.66 Pain Relevance 0.12

In the meanwhile, phosphorylation of p53 at serine 15, accumulation of p53 and increased the expression of its downstream target genes, p21 and Bax induced by ASA.

Positive_regulation (increased) of Phosphorylation (phosphorylation) of p53

4) Confidence 0.33 Published 2003 Journal Eur. J. Clin. Invest. Section Body Doc Link 14511359 Disease Relevance 0.14 Pain Relevance 0

Indeed, phosphorylation of p53 activates the release of cytochrome c and caspase-9 via target genes such as Bax (BCL-2 [B-cell lymphoma-2] associated protein), Bak (BCL-2 homologous antagonist/killer), Noxa (damage), and PUMA (p53 upregulated modulator of apoptosis) [27].

Positive_regulation (activates) of Phosphorylation (phosphorylation) of p53 in B-cell associated with lymphatic system cancer, antagonist and apoptosis

5) Confidence 0.32 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2660376 Disease Relevance 1.15 Pain Relevance 0.05

DNA damage can change phosphorylation levels of the p53 protein, resulting in cell cycle arrest and apoptosis [22,23].

Positive_regulation (change) of Phosphorylation (phosphorylation) of p53 protein associated with apoptosis

6) Confidence 0.30 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2660376 Disease Relevance 0.82 Pain Relevance 0

In addition, Okabe et al., demonstrated that FK228 treatment induces a diverse range of histone and non-histone protein acetylation in BCR-ABL transfected cell lines, including acetylation of p53, Hsp90 and BCR-ABL [81].

Positive_regulation (induces) of Phosphorylation (acetylation) of p53

7) Confidence 0.06 Published 2010 Journal Invest New Drugs Section Body Doc Link PMC3003795 Disease Relevance 0.74 Pain Relevance 0

Andrographolide induces apoptosis in human cancer cells via the activation of caspase 8, pro-apoptotic Bcl-2 family members Bax conformational change, release of cytochrome C from mitochondria and activation of caspase cascade [52] and/or via the activation of tumour suppressor p53 by ROS-dependent c-Jun NH2-terminal kinase (JNK) activation, thereby increasing p53 phosphorylation and protein stabilization [53,54].

Positive_regulation (increasing) of Phosphorylation (phosphorylation) of p53 associated with cancer and apoptosis

8) Confidence 0.05 Published 2010 Journal Chin Med Section Body Doc Link PMC2881933 Disease Relevance 1.01 Pain Relevance 0

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