INT113346

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Context Info
Confidence 0.35
First Reported 2003
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 10
Total Number 11
Disease Relevance 5.73
Pain Relevance 0.15

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (MDM2) intracellular (MDM2) enzyme binding (MDM2)
protein complex assembly (MDM2) protein complex (MDM2) ligase activity (MDM2)
Anatomy Link Frequency
nucleus 2
cleavage 1
MDM2 (Homo sapiens)
Pain Link Frequency Relevance Heat
imagery 46 79.36 Quite High
Neuropeptide 1 73.36 Quite High
Kinase C 24 50.64 Quite High
Arthritis 107 50.16 Quite High
aspirin 6 50.00 Quite Low
addiction 4 50.00 Quite Low
IPN 2 48.40 Quite Low
Inflammation 48 42.04 Quite Low
cytokine 26 29.88 Quite Low
COX2 2 10.00 Low Low
Disease Link Frequency Relevance Heat
Cancer 212 100.00 Very High Very High Very High
Stress 19 99.72 Very High Very High Very High
Osteogenic Sarcomas 5 99.04 Very High Very High Very High
Disease 33 97.76 Very High Very High Very High
Bone Cancer 6 97.16 Very High Very High Very High
Apoptosis 34 97.00 Very High Very High Very High
Leukemia 6 94.60 High High
Chromosome Aberrations 1 93.44 High High
Pancreatic Cancer 1 91.96 High High
Acquired Immune Deficiency Syndrome Or Hiv Infection 7 91.04 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Phosphorylation of p53 in response to stress disrupts its binding with HDM2, blocks ubiquitination and proteolysis, and results in a rapid increase in p53 protein levels, allowing p53 to enter the nucleus, bind to DNA, and induce expression of genes controlling cell cycle, apoptosis, DNA repair, and cellular senescence [100].
HDM2 Binding (binding) of in nucleus associated with stress, aging and apoptosis
1) Confidence 0.35 Published 2010 Journal Biol Trace Elem Res Section Body Doc Link PMC2855032 Disease Relevance 0.51 Pain Relevance 0.04
This class includes ligands that bound at signaling complexes such as MDM2–p53, farnesyltransfrease–h-ras, and histone acetyltransferase–p53.
MDM2 Binding (bound) of
2) Confidence 0.35 Published 2010 Journal PLoS Computational Biology Section Body Doc Link PMC2816688 Disease Relevance 0.09 Pain Relevance 0
One of the well-investigated target PPIs is the interaction between tumor suppressor protein p53 and murine double-minute-2 protein (MDM2) [6-8].
MDM2 Binding (interaction) of associated with cancer
3) Confidence 0.27 Published 2007 Journal BMC Pharmacol Section Body Doc Link PMC2045083 Disease Relevance 0.78 Pain Relevance 0
One of the well-investigated target PPIs is the interaction between tumor suppressor protein p53 and murine double-minute-2 protein (MDM2) [6-8].
double-minute-2 protein Binding (interaction) of associated with cancer
4) Confidence 0.24 Published 2007 Journal BMC Pharmacol Section Body Doc Link PMC2045083 Disease Relevance 0.78 Pain Relevance 0
It is connected to three genes: TP53 in its active state in the nucleus (through state_transition), TPPP (TPPP can phosphorylate TP53) and MDM2 (MDM2 can inhibit the activation of TP53).
MDM2 Binding (state) of in nucleus
5) Confidence 0.23 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2855702 Disease Relevance 0.51 Pain Relevance 0.03
Second on the list is Mdm2 (MDM2), a p53 binding protein.
Mdm2 Binding (binding) of
6) Confidence 0.23 Published 2010 Journal Human Genomics and Proteomics : HGP Section Body Doc Link PMC2958630 Disease Relevance 0.05 Pain Relevance 0.03
Second on the list is Mdm2 (MDM2), a p53 binding protein.
MDM2 Binding (binding) of
7) Confidence 0.23 Published 2010 Journal Human Genomics and Proteomics : HGP Section Body Doc Link PMC2958630 Disease Relevance 0.05 Pain Relevance 0.03
Disruption of p53-murine double minute-2 (MDM2) complex formation resulted in increasing the expression of MDM2 60-kDa cleavage fragment.
MDM2 Binding (formation) of in cleavage
8) Confidence 0.22 Published 2003 Journal Eur. J. Clin. Invest. Section Body Doc Link 14511359 Disease Relevance 0.12 Pain Relevance 0
the HDM2 promoter leading to HDM2 overexpression has been recently associated
HDM2 Binding (associated) of
9) Confidence 0.16 Published 2008 Journal PPAR Research Section Body Doc Link PMC2423003 Disease Relevance 1.12 Pain Relevance 0
For example, gain of chromosome 8q23 and CDK4 alone or together with MDM2 is associated with poor prognosis in osteosarcoma [34].
MDM2 Binding (associated) of associated with osteogenic sarcomas
10) Confidence 0.05 Published 2007 Journal Cytojournal Section Body Doc Link PMC1872031 Disease Relevance 1.10 Pain Relevance 0
Following successes in cancer therapy derived from targeting the MDM2-p53 interaction [12–14], the importance of protein-protein interactions is increasingly recognized, both for understanding cell physiology and for developing novel treatments [15].
MDM2-p53 Binding (interaction) of associated with cancer
11) Confidence 0.05 Published 2009 Journal Target Oncol Section Body Doc Link PMC2778706 Disease Relevance 0.62 Pain Relevance 0.04

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