INT113348

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Context Info
Confidence 0.28
First Reported 2003
Last Reported 2006
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 1.49
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (TP53) nucleoplasm (TP53) mitochondrion (TP53)
endoplasmic reticulum (TP53) enzyme binding (TP53) protein complex assembly (TP53)
Anatomy Link Frequency
cleavage 2
lung 2
TP53 (Homo sapiens)
Pain Link Frequency Relevance Heat
aspirin 4 50.00 Quite Low
COX2 1 10.00 Low Low
palliative 2 5.00 Very Low Very Low Very Low
cINOD 2 5.00 Very Low Very Low Very Low
addiction 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Lung Cancer 20 98.94 Very High Very High Very High
Non-small-cell Lung Cancer 26 98.70 Very High Very High Very High
Death 1 98.52 Very High Very High Very High
Apoptosis 6 95.52 Very High Very High Very High
Carcinoma 2 94.00 High High
Breast Cancer 1 84.00 Quite High
Chromosomal Instability 1 77.92 Quite High
Metastasis 12 74.48 Quite High
Cancer 49 69.52 Quite High
Mouth Cancer 2 63.64 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Disruption of p53-murine double minute-2 (MDM2) complex formation resulted in increasing the expression of MDM2 60-kDa cleavage fragment.
Negative_regulation (Disruption) of p53 Binding (formation) of in cleavage
1) Confidence 0.28 Published 2003 Journal Eur. J. Clin. Invest. Section Body Doc Link 14511359 Disease Relevance 0.13 Pain Relevance 0
For example, p53 mediated cell death of NSCLC lung cancer cell line H1299 was impeded by PTTG-1 expression by blocking the specific binding of p53 to DNA and inhibiting the transcriptional function of p53 [14].
Negative_regulation (blocking) of p53 Binding (binding) of in lung associated with lung cancer, non-small-cell lung cancer and death
2) Confidence 0.06 Published 2006 Journal J Carcinog Section Body Doc Link PMC1360069 Disease Relevance 1.36 Pain Relevance 0

General Comments

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