INT11335

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Context Info
Confidence 0.51
First Reported 1984
Last Reported 2010
Negated 10
Speculated 8
Reported most in Abstract
Documents 46
Total Number 55
Disease Relevance 22.30
Pain Relevance 15.42

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Ptger2) signal transducer activity (Ptger2)
Anatomy Link Frequency
PGE2 12
plasma 2
spinal 2
spinal cord 2
brain 1
Ptger2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Inflammation 309 100.00 Very High Very High Very High
agonist 125 100.00 Very High Very High Very High
cINOD 52 100.00 Very High Very High Very High
Inflammatory mediators 22 100.00 Very High Very High Very High
analgesia 17 99.84 Very High Very High Very High
Spinal cord 22 99.50 Very High Very High Very High
Analgesic 28 99.40 Very High Very High Very High
Dorsal horn 4 99.20 Very High Very High Very High
medulla 3 99.20 Very High Very High Very High
Antihyperalgesic 2 99.12 Very High Very High Very High
Disease Link Frequency Relevance Heat
Cancer 394 100.00 Very High Very High Very High
INFLAMMATION 386 100.00 Very High Very High Very High
Breast Cancer 8 100.00 Very High Very High Very High
Injury 33 99.80 Very High Very High Very High
Stress 14 99.54 Very High Very High Very High
Convulsion 4 99.54 Very High Very High Very High
Pulpitis 3 98.56 Very High Very High Very High
Nociception 109 98.20 Very High Very High Very High
Birth Weight 11 98.18 Very High Very High Very High
Apoptosis 26 97.84 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Thus, the increase in uterine contractile activity induced by mifepristone preceded significant changes in concentrations of PGE-2 and PGF-2 alpha in the uterus and so could not have been caused by these changes.
Regulation (concentrations) of PGE-2 in uterine
1) Confidence 0.51 Published 1992 Journal J. Reprod. Fertil. Section Abstract Doc Link 1552472 Disease Relevance 0.14 Pain Relevance 0.05
In this study, we demonstrate the relevance of such a relationship for COX-inhibitors by modelling the effect of naproxen on prostaglandin E2 (PGE(2)) and thromboxane B2 (TXB(2)) in a chronic inflammation model in rats.
Regulation (effect) of prostaglandin E2 associated with inflammation
2) Confidence 0.44 Published 2010 Journal Eur J Pain Section Abstract Doc Link 19679500 Disease Relevance 0.27 Pain Relevance 0.18
The current study was designed to investigate the roles of PGE2 and EP1 receptors in the spinal cord in the development and maintenance of inflammatory pain, using behavioral, microdialysis, and intracellular calcium ion concentration ([Ca2+]i) assays.
Spec (investigate) Regulation (roles) of PGE2 in spinal cord associated with ipn and spinal cord
3) Confidence 0.36 Published 2002 Journal Anesthesiology Section Abstract Doc Link 12411813 Disease Relevance 0.37 Pain Relevance 0.40
Effects of PGE2 with or without propiverine on pressure-related parameters
Regulation (Effects) of PGE2
4) Confidence 0.35 Published 2010 Journal Korean Journal of Urology Section Body Doc Link PMC2855469 Disease Relevance 0.09 Pain Relevance 0
Effects of PGE2 with or without propiverine on IAP recorded at the points of BP, TP, and MP
Regulation (Effects) of PGE2
5) Confidence 0.35 Published 2010 Journal Korean Journal of Urology Section Body Doc Link PMC2855469 Disease Relevance 0 Pain Relevance 0
This study was designed to investigate the roles of PGE2 and EP1 receptors in the spinal cord in the nociceptive transmission, using behavioral and intracellular calcium ion concentration ([Ca2+]i) assays and in situ hybridization.
Spec (investigate) Regulation (roles) of PGE2 in spinal cord associated with nociception and spinal cord
6) Confidence 0.34 Published 2004 Journal Brain Res. Section Abstract Doc Link 15126118 Disease Relevance 0.33 Pain Relevance 0.27
This decrease in PG levels at 15 min was not observed in the rats that had seizures after injury and both PGE2 and TxB2 levels remained high in hemispheres and brainstem.
Regulation (high) of PGE2 in brainstem associated with medulla, convulsion and injury
7) Confidence 0.34 Published 1988 Journal J. Neurotrauma Section Abstract Doc Link 3249309 Disease Relevance 0.76 Pain Relevance 0.09
Increased PGE2 levels may in addition stimulate the microglial EP2 receptor, which is linked to cAMP formation [74] and thereby contribute to the inactivation of microglia.
Spec (may) Regulation (stimulate) of microglial EP2 receptor in microglia
8) Confidence 0.28 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2819253 Disease Relevance 0.34 Pain Relevance 0.34
2in were not significantly different after PGE2 treatment (Table 1), suggesting that PGE2 does not alter the kinetics of the fast-inactivating ATP currents.
Neg (not) Regulation (different) of PGE2
9) Confidence 0.28 Published 2007 Journal Mol Pain Section Body Doc Link PMC2063498 Disease Relevance 0 Pain Relevance 0
M), onto the recorded cell had no effect on the PGE2 action (Figs. 5C and 5D).
Neg (no) Regulation (effect) of PGE2
10) Confidence 0.28 Published 2007 Journal Mol Pain Section Body Doc Link PMC2063498 Disease Relevance 0.27 Pain Relevance 0.22
M, elicited maximal ATP currents in both cases, although the level of maximal response in PGE2 was 1.55-fold larger.
Regulation (response) of PGE2
11) Confidence 0.28 Published 2007 Journal Mol Pain Section Body Doc Link PMC2063498 Disease Relevance 0 Pain Relevance 0.03
In contrast, the PKC inhibitor, bisindolymaleimide (Bis) did not change the potentiating action of PGE2.
Neg (not) Regulation (change) of PGE2 in PGE2
12) Confidence 0.28 Published 2007 Journal Mol Pain Section Abstract Doc Link PMC2063498 Disease Relevance 0.39 Pain Relevance 0.25
Dose-responses of ATP responses in the absence and presence of PGE2 (1 ?
Regulation (responses) of PGE2
13) Confidence 0.28 Published 2007 Journal Mol Pain Section Body Doc Link PMC2063498 Disease Relevance 0 Pain Relevance 0
The results suggest that PGE2 and alpha 2 adrenoceptor agonists may regulate glucose metabolism through similar transduction mechanisms, and that a guanine nucleotide binding regulatory (G) protein modulates certain metabolic effects of prostaglandins and adrenergic agonists.
Spec (may) Regulation (regulate) of PGE2 associated with agonist
14) Confidence 0.26 Published 1989 Journal Arch. Biochem. Biophys. Section Abstract Doc Link 2563646 Disease Relevance 0.09 Pain Relevance 0.45
In addition, we investigated whether different analgesic drugs orally administered at antihyperalgesic doses were able to prevent the changes in PGE2 and TNF-alpha spinal levels associated with hindpaw inflammation.
Regulation (changes) of PGE2 in spinal associated with antihyperalgesic, inflammation and analgesic
15) Confidence 0.25 Published 2007 Journal Anesth. Analg. Section Abstract Doc Link 17377112 Disease Relevance 0.58 Pain Relevance 0.38
We also assessed, by enzyme immunoassay, the effects of the combination on peripheral PGE-2 levels: CAF did not alter the inhibitory effect of ASA on PGE-2 synthesis.
Regulation (effects) of PGE-2 associated with aspirin
16) Confidence 0.23 Published 2008 Journal Eur J Pain Section Abstract Doc Link 17507271 Disease Relevance 1.15 Pain Relevance 0.71
We conclude that NE affected stimulated PGE2 release via alpha2-adrenoceptors on cells other than cutaneous afferents while kappa-opioid receptors are expressed in peripheral terminals of cutaneous afferents and their activation reduced CGRP release and secondary PGE2 formation.
Regulation (affected) of PGE2 in PGE2 associated with kappa opioid receptor and calcitonin gene-related peptide
17) Confidence 0.18 Published 2001 Journal Neuroreport Section Abstract Doc Link 11447314 Disease Relevance 0 Pain Relevance 0.56
In [Ca2+]i assays, we measured [Ca2+]i in the dorsal horn of spinal cord slices and examined the effects of PGE2 and ONO-8711 perfusion on the [Ca2+]i changes.
Spec (examined) Regulation (effects) of PGE2 in dorsal horn associated with dorsal horn and spinal cord
18) Confidence 0.18 Published 2004 Journal Brain Res. Section Abstract Doc Link 15126118 Disease Relevance 0.55 Pain Relevance 0.74
We studied the actions of PGE2 on ATP-activated currents in dissociated DRG neurons under voltage-clamp conditions.
Regulation (actions) of PGE2 in PGE2
19) Confidence 0.17 Published 2007 Journal Mol Pain Section Abstract Doc Link PMC2063498 Disease Relevance 0.26 Pain Relevance 0.09
Our study elucidates the mechanism of an acute action of PGE2 on ATP currents.
Regulation (action) of PGE2
20) Confidence 0.17 Published 2007 Journal Mol Pain Section Body Doc Link PMC2063498 Disease Relevance 0.83 Pain Relevance 0.36

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