INT11336

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.78
First Reported 1980
Last Reported 2007
Negated 0
Speculated 0
Reported most in Abstract
Documents 23
Total Number 23
Disease Relevance 2.88
Pain Relevance 9.07

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Ptgfr) plasma membrane (Ptgfr) cytoplasm (Ptgfr)
signal transducer activity (Ptgfr)
Anatomy Link Frequency
brain 4
mossy fiber 4
myometrium 2
neurons 1
PGE2 1
Ptgfr (Rattus norvegicus)
Pain Link Frequency Relevance Heat
MU agonist 8 99.78 Very High Very High Very High
Glutamate 8 99.76 Very High Very High Very High
agonist 37 99.64 Very High Very High Very High
Clonidine 25 99.34 Very High Very High Very High
Dopamine 8 99.14 Very High Very High Very High
wide dynamic range 18 99.04 Very High Very High Very High
Serotonin 8 98.88 Very High Very High Very High
tetrodotoxin 8 98.08 Very High Very High Very High
Potency 1 96.56 Very High Very High Very High
Paracetamol 6 92.00 High High
Disease Link Frequency Relevance Heat
Hypotension 14 98.84 Very High Very High Very High
Hypoxia 8 98.56 Very High Very High Very High
Reprotox - General 1 1 98.40 Very High Very High Very High
Hyperalgesia 11 91.68 High High
Heart Rate Under Development 2 83.76 Quite High
Cv Unclassified Under Development 2 79.56 Quite High
Nociception 4 75.00 Quite High
INFLAMMATION 5 73.84 Quite High
Dysmenorrhea 9 70.20 Quite High
Neuropathic Pain 2 64.24 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The centrally acting antihypertensive drug clonidine has been found to stimulate the synthesis of PGF2 alpha in the brain.
Gene_expression (synthesis) of PGF2 alpha in brain associated with clonidine
1) Confidence 0.78 Published 1980 Journal Prostaglandins Section Abstract Doc Link 7413993 Disease Relevance 0.07 Pain Relevance 0.59
Therefore it is likely that the synthesis of PGF2 alpha does not interfere with the hypotensive effect of clonidine.
Gene_expression (synthesis) of PGF2 alpha associated with hypotension and clonidine
2) Confidence 0.78 Published 1980 Journal Prostaglandins Section Abstract Doc Link 7413993 Disease Relevance 0.69 Pain Relevance 1.18
It appeared, therefore, that certain receptor agonists were able to modulate PGF2 alpha synthesis in the hippocampal mossy fiber synaptosomal preparation.
Gene_expression (synthesis) of PGF2 alpha in mossy fiber associated with agonist
3) Confidence 0.78 Published 1993 Journal Prostaglandins Leukot. Essent. Fatty Acids Section Abstract Doc Link 7905646 Disease Relevance 0 Pain Relevance 0.47
Dexketoprofen was found to be a potent inhibitor of this PGF2 alpha production in rat brain (IC50 = 6.2 nM), and it completely suppressed PGF2 alpha production at 1 microM concentration.
Gene_expression (production) of PGF2 alpha in brain
4) Confidence 0.73 Published 1997 Journal Chirality Section Abstract Doc Link 9176993 Disease Relevance 0.06 Pain Relevance 0.21
In addition, inhibition of PGF2 alpha synthesis by dexketoprofen was highly stereoselective since the enantiomer (-)-R-ketoprofen was significantly less potent (IC50 = 294 nM); with this enantiomer, even at high concentrations such as 1 microM, less than 60% inhibition was achieved.
Gene_expression (synthesis) of PGF2 alpha
5) Confidence 0.73 Published 1997 Journal Chirality Section Abstract Doc Link 9176993 Disease Relevance 0.06 Pain Relevance 0.20
Glutamate and its agonists had no effect on PGF2 alpha synthesis.
Gene_expression (synthesis) of PGF2 alpha associated with glutamate and agonist
6) Confidence 0.68 Published 1993 Journal Prostaglandins Leukot. Essent. Fatty Acids Section Abstract Doc Link 7905646 Disease Relevance 0 Pain Relevance 0.39
However, norepinephrine, serotonin and dopamine exerted receptor-mediated stimulations of PGF2 alpha production.
Gene_expression (production) of PGF2 alpha associated with dopamine and serotonin
7) Confidence 0.68 Published 1993 Journal Prostaglandins Leukot. Essent. Fatty Acids Section Abstract Doc Link 7905646 Disease Relevance 0 Pain Relevance 0.48
For the first 15 min the PGE2 level was twice that of PGF2 alpha, the levels then equalized and after 90 min the PGE2 level was less than that of PGF2 alpha.
Gene_expression (equalized) of PGF2
8) Confidence 0.67 Published 1980 Journal Eur. J. Pharmacol. Section Abstract Doc Link 7353582 Disease Relevance 0.15 Pain Relevance 0.20
Both PGE2 and PGF2 produced increases in background discharges of WDR and NS neurons, although this effect was most consistently observed with WDR neurons and PGE2.
Gene_expression (produced) of PGF2 in PGE2 associated with wide dynamic range
9) Confidence 0.53 Published 2002 Journal Pain Section Abstract Doc Link 12031777 Disease Relevance 0.41 Pain Relevance 0.84
Mossy fiber nerve endings were isolated from rat hippocampi and used to determine the effects of receptor activation on the production of prostaglandin F2 alpha (PGF2 alpha).
Gene_expression (production) of F2 alpha in Mossy fiber
10) Confidence 0.52 Published 1993 Journal Prostaglandins Leukot. Essent. Fatty Acids Section Abstract Doc Link 7905646 Disease Relevance 0 Pain Relevance 0.37
In addition, a kappa opioid agonist decreased PGF2 alpha synthesis in unstimulated and depolarized synaptosomes.
Gene_expression (synthesis) of PGF2 alpha associated with mu agonist
11) Confidence 0.52 Published 1993 Journal Prostaglandins Leukot. Essent. Fatty Acids Section Abstract Doc Link 7905646 Disease Relevance 0 Pain Relevance 0.49
Prostaglandins F2 alpha synthesis in the hippocampal mossy fiber synaptosomal preparation: II.
Gene_expression (synthesis) of F2 alpha in mossy fiber
12) Confidence 0.52 Published 1993 Journal Prostaglandins Leukot. Essent. Fatty Acids Section Title Doc Link 7905646 Disease Relevance 0 Pain Relevance 0.41
Mossy fiber nerve endings were isolated from rat hippocampi and used to determine the effects of receptor activation on the production of prostaglandin F2 alpha (PGF2 alpha).
Gene_expression (production) of PGF2 alpha in Mossy fiber
13) Confidence 0.52 Published 1993 Journal Prostaglandins Leukot. Essent. Fatty Acids Section Abstract Doc Link 7905646 Disease Relevance 0 Pain Relevance 0.37
The agonist-evoked increases in PGF2 alpha production were attenuated by phospholipase A2 inhibitors, L-type voltage-sensitive Ca2+ blockers and a K+ channel activator, but they were insensitive to tetrodotoxin.
Gene_expression (production) of PGF2 alpha associated with tetrodotoxin and agonist
14) Confidence 0.52 Published 1993 Journal Prostaglandins Leukot. Essent. Fatty Acids Section Abstract Doc Link 7905646 Disease Relevance 0 Pain Relevance 0.49
Concentrations of PGE-2 and PGF-2 alpha were significantly higher at 48 h when abortion had occurred in all animals (6.5 +/- 2.6 vs. 2.4 +/- 1.7 ng PGE-2/g and 30.4 +/- 8.9 vs. 9.3 +/- 5.6 ng PGF-2 alpha/g).
Gene_expression (Concentrations) of PGF-2 alpha associated with reprotox - general 1
15) Confidence 0.51 Published 1992 Journal J. Reprod. Fertil. Section Abstract Doc Link 1552472 Disease Relevance 0.16 Pain Relevance 0.07
Dexketoprofen was found to be a potent inhibitor of this PGF2 alpha production in rat brain (IC50 = 6.2 nM), and it completely suppressed PGF2 alpha production at 1 microM concentration.
Gene_expression (production) of PGF2 alpha in brain
16) Confidence 0.50 Published 1997 Journal Chirality Section Abstract Doc Link 9176993 Disease Relevance 0.07 Pain Relevance 0.22
Significant levels of prostaglandin F2 alpha (PGF2 alpha) were synthesized in rat brain fragments after 10 min of incubation at 37 degrees C.
Gene_expression (synthesized) of PGF2 alpha in brain
17) Confidence 0.50 Published 1997 Journal Chirality Section Abstract Doc Link 9176993 Disease Relevance 0.07 Pain Relevance 0.24
Under O2, PGE2 and PGF2 alpha production diminished significantly (P less than 0.05 and P less than 0.01, normoxia vs. hypoxia, respectively) whereas PGe1 increased (P less than 0.05).
Gene_expression (production) of PGF2 associated with hypoxia
18) Confidence 0.34 Published 1981 Journal Prostaglandins Med Section Abstract Doc Link 6948305 Disease Relevance 0.55 Pain Relevance 0.04
Both PGE2 and PGF2 produced increases in background discharges of WDR and NS neurons, although this effect was most consistently observed with WDR neurons and PGE2.
Gene_expression (produced) of PGF2 in neurons associated with wide dynamic range
19) Confidence 0.18 Published 2002 Journal Pain Section Abstract Doc Link 12031777 Disease Relevance 0.41 Pain Relevance 0.84
Among seven PGs tested at 10(-6) M, only PGE2, PGE1, PGA2, and 16,16-dimethyl PGE2 significantly enhanced LH-RH secretion. 8-iso PGE2 weakly stimulated LH-RH secretion, whereas PGF2 alpha and PGD2 were ineffective.
Gene_expression (ineffective) of PGF2 alpha
20) Confidence 0.16 Published 1984 Journal Neuroendocrinology Section Abstract Doc Link 6096749 Disease Relevance 0 Pain Relevance 0.78

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox