INT113368

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Context Info
Confidence 0.45
First Reported 2003
Last Reported 2005
Negated 0
Speculated 1
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0.71
Pain Relevance 0.35

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Edn1) extracellular region (Edn1) cell-cell signaling (Edn1)
cytoplasm (Edn1)
Anatomy Link Frequency
neurons 2
Edn1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
antagonist 3 99.00 Very High Very High Very High
Rostral ventrolateral medulla 6 98.64 Very High Very High Very High
medulla 1 91.36 High High
nociceptor 2 25.00 Low Low
Kinase C 3 5.00 Very Low Very Low Very Low
Versed 2 5.00 Very Low Very Low Very Low
analgesia 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Nociception 3 92.48 High High
Adult Respiratory Distress Syndrome 13 92.28 High High
Pressure And Volume Under Development 7 83.12 Quite High
Lung Injury 2 77.16 Quite High
Sepsis 2 76.36 Quite High
Paralysis 8 41.52 Quite Low
Heart Rate Under Development 11 17.68 Low Low
Body Weight 5 5.00 Very Low Very Low Very Low
Weight Gain 3 5.00 Very Low Very Low Very Low
Necrosis 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In this study, we examined whether vasomotor and respiratory neurons in RVLM participate in above-mentioned responses and whether those neurons respond to direct iontophoretic application of ET-1 and/or an ET-A receptor antagonist, FR139317. 2.
Spec (whether) Regulation (respond) of Spec (whether) Negative_regulation (application) of ET-1 in neurons associated with rostral ventrolateral medulla and antagonist
1) Confidence 0.45 Published 2003 Journal Cell. Mol. Neurobiol. Section Abstract Doc Link 14514025 Disease Relevance 0.16 Pain Relevance 0.32
However, further studies are warranted to fully elucidate the effects of non-selective ET-1 receptor blockade on activation of PKC?
Regulation (effects) of Negative_regulation (blockade) of ET-1 receptor
2) Confidence 0.26 Published 2005 Journal Crit Care Section Body Doc Link PMC1413997 Disease Relevance 0.56 Pain Relevance 0.03

General Comments

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