INT113376

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Context Info
Confidence 0.69
First Reported 2003
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 7
Total Number 7
Disease Relevance 0.93
Pain Relevance 6.36

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Nav1) cytoskeleton (Nav1) cytoplasm (Nav1)
Anatomy Link Frequency
neurons 2
skeletal muscle 1
nociceptor 1
central nervous systems 1
Nav1 (Mus musculus)
Pain Link Frequency Relevance Heat
Nav1.6 14 100.00 Very High Very High Very High
nav1.8 10 100.00 Very High Very High Very High
Nav1.9 6 100.00 Very High Very High Very High
Nav1.2 5 100.00 Very High Very High Very High
nociceptor 7 99.66 Very High Very High Very High
nav1.3 8 97.88 Very High Very High Very High
Nav1.7 2 97.44 Very High Very High Very High
sodium channel 23 95.92 Very High Very High Very High
Nerve growth factor 6 93.72 High High
IPN 3 88.44 High High
Disease Link Frequency Relevance Heat
Inflammatory Pain 3 88.44 High High
INFLAMMATION 1 79.16 Quite High
Pain 3 75.04 Quite High
Neuropathic Pain 2 71.60 Quite High
Ganglion Cysts 2 66.56 Quite High
Nervous System Injury 2 61.64 Quite High
Death 14 48.40 Quite Low
Apoptosis 1 32.04 Quite Low
Hypoxia 1 27.40 Quite Low
Muscular Dystrophy 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The mRNA isoforms, Nav1.2 and Nav1.6, are the most frequently detected by single cell analysis in the two cell types while Nav1.3 and Nav1.7 are also moderately expressed in embryonic hippocampal neurons and in neonatal utricular hair cells respectively.
Transcription (detected) of Nav1 in neurons associated with nav1.3, nav1.2, nav1.7 and nav1.6
1) Confidence 0.69 Published 2005 Journal Neuroscience Section Abstract Doc Link 15664695 Disease Relevance 0 Pain Relevance 0.67
The mRNA isoforms, Nav1.2 and Nav1.6, are the most frequently detected by single cell analysis in the two cell types while Nav1.3 and Nav1.7 are also moderately expressed in embryonic hippocampal neurons and in neonatal utricular hair cells respectively.
Transcription (detected) of Nav1 in neurons associated with nav1.3, nav1.2, nav1.7 and nav1.6
2) Confidence 0.69 Published 2005 Journal Neuroscience Section Abstract Doc Link 15664695 Disease Relevance 0 Pain Relevance 0.67
By contrast, nociceptor-associated mRNA transcripts (e.g., Nav1.8, P2xr3, and Runx-1) were downregulated, resulting in lower levels of protein and functional expression. qRT-PCR analysis also showed lowered levels of expression of nociceptor-specific pre-mRNA transcripts.
Transcription (transcripts) of Nav1 in nociceptor associated with nociceptor and nav1.8
3) Confidence 0.69 Published 2010 Journal J. Neurosci. Section Abstract Doc Link 20702715 Disease Relevance 0.53 Pain Relevance 1.43
Interestingly, Nav1.4 in our experiments with skeletal muscle colocalized with syntrophin, similarly to what has been described for the cardiac isoform Nav1.5 (Gee et al., 1998; Gavillet et al., 2006).
Transcription (described) of Nav1 in skeletal muscle
4) Confidence 0.58 Published 2008 Journal The Journal of General Physiology Section Body Doc Link PMC2483333 Disease Relevance 0 Pain Relevance 0.03
We find that as in control animals, most mutant nodes of Ranvier had Nav1.6 in high-density clusters in the peripheral and central nervous systems; the localization of Nav1.2 and the protein levels of Nav1.2 and Nav1.6 were also normal in the CGT-deficient mouse.
Transcription (levels) of Nav1 in central nervous systems associated with nav1.2 and nav1.6
5) Confidence 0.53 Published 2003 Journal Glia Section Abstract Doc Link 14515333 Disease Relevance 0 Pain Relevance 1.00
In contrast, we observed activity-dependent down-regulation of Nav1.8 and Nav1.9 mRNA and protein levels after stimulation, as demonstrated by quantitative polymerase chain reaction and immunocytochemistry.
Transcription (levels) of Nav1 associated with nav1.8 and nav1.9
6) Confidence 0.53 Published 2003 Journal J. Neurosci. Res. Section Abstract Doc Link 14515348 Disease Relevance 0.20 Pain Relevance 1.29
In contrast, we observed activity-dependent down-regulation of Nav1.8 and Nav1.9 mRNA and protein levels after stimulation, as demonstrated by quantitative polymerase chain reaction and immunocytochemistry.
Transcription (levels) of Nav1 associated with nav1.8 and nav1.9
7) Confidence 0.53 Published 2003 Journal J. Neurosci. Res. Section Abstract Doc Link 14515348 Disease Relevance 0.20 Pain Relevance 1.29

General Comments

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