INT113377

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Context Info
Confidence 0.70
First Reported 2003
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.23
Pain Relevance 1.46

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Nav1) cytoskeleton (Nav1) cytoplasm (Nav1)
Anatomy Link Frequency
nerve 2
Nav1 (Mus musculus)
Pain Link Frequency Relevance Heat
Nav1.7 47 100.00 Very High Very High Very High
Nav1.6 8 100.00 Very High Very High Very High
Nav1.2 3 98.80 Very High Very High Very High
sodium channel 18 78.08 Quite High
potassium channel 3 76.92 Quite High
Congenital analgesia 3 67.36 Quite High
Pain 44 50.00 Quite Low
addiction 5 49.08 Quite Low
Action potential 6 44.88 Quite Low
Analgesic 3 29.92 Quite Low
Disease Link Frequency Relevance Heat
Pain 46 65.12 Quite High
Somatoform Disorder 10 54.08 Quite High
Erythermalgia 12 53.72 Quite High
Channelopathies 4 52.88 Quite High
Nociception 1 41.80 Quite Low
Injury 5 5.00 Very Low Very Low Very Low
Bites And Stings 3 5.00 Very Low Very Low Very Low
Polio 3 5.00 Very Low Very Low Very Low
Febrile Convulsions 3 5.00 Very Low Very Low Very Low
Fever 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Thus, transverse bands are not required for Nav1.6 clustering and localization at nodes or for exclusion of Nav1.2 from myelinated nerve fibers, but are required for the maintenance of nodal Nav1.6 cluster size and density.
Neg (not) Positive_regulation (required) of Localization (localization) of Nav1 in nerve associated with nav1.2 and nav1.6
1) Confidence 0.70 Published 2003 Journal Glia Section Abstract Doc Link 14515333 Disease Relevance 0 Pain Relevance 1.04
It is therefore conceivable that the SCN9A mutations described here also cause misfolding of the channel which leads to ER retention and hence defective cell surface localization of Nav1.7.
Positive_regulation (cause) of Localization (localization) of Nav1.7 associated with nav1.7
2) Confidence 0.48 Published 2010 Journal Human Mutation Section Body Doc Link PMC2966863 Disease Relevance 0.23 Pain Relevance 0.43

General Comments

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