INT113384

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Context Info
Confidence 0.62
First Reported 2003
Last Reported 2010
Negated 7
Speculated 7
Reported most in Body
Documents 20
Total Number 27
Disease Relevance 8.57
Pain Relevance 16.15

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Nav1) cytoskeleton (Nav1) cytoplasm (Nav1)
Anatomy Link Frequency
nerve 6
neurons 6
sensory neurons 4
spike 4
sciatic nerves 4
Nav1 (Mus musculus)
Pain Link Frequency Relevance Heat
sodium channel 240 100.00 Very High Very High Very High
Inflammation 124 100.00 Very High Very High Very High
Nav1.2 67 100.00 Very High Very High Very High
Nav1.7 60 100.00 Very High Very High Very High
nav1.8 44 100.00 Very High Very High Very High
Nav1.9 43 100.00 Very High Very High Very High
Nav1.6 29 100.00 Very High Very High Very High
nav1.3 21 100.00 Very High Very High Very High
Spinal cord 7 100.00 Very High Very High Very High
hyperexcitability 27 99.76 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 131 100.00 Very High Very High Very High
Convulsion 181 99.76 Very High Very High Very High
Multiple Sclerosis 9 99.76 Very High Very High Very High
Neuropathic Pain 26 99.68 Very High Very High Very High
Experimental Autoimmune Encephalomyelitis 2 98.88 Very High Very High Very High
Targeted Disruption 38 98.72 Very High Very High Very High
Neuroma 79 96.16 Very High Very High Very High
Pain 103 95.00 High High
Febrile Convulsions 3 93.96 High High
Disease 35 93.24 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We examined the effect of electrical stimulation on the expression of Nav1.3, Nav1.8, and Nav1.9 by using cultured embryonic mouse sensory neurons under conditions in which nerve growth factor (NGF) was not limiting.
Spec (examined) Regulation (effect) of Gene_expression (expression) of Nav1 in nerve associated with nav1.3, nerve growth factor, nav1.8 and nav1.9
1) Confidence 0.62 Published 2003 Journal J. Neurosci. Res. Section Abstract Doc Link 14515348 Disease Relevance 0.24 Pain Relevance 1.33
We examined the effect of electrical stimulation on the expression of Nav1.3, Nav1.8, and Nav1.9 by using cultured embryonic mouse sensory neurons under conditions in which nerve growth factor (NGF) was not limiting.
Spec (examined) Regulation (effect) of Gene_expression (expression) of Nav1 in nerve associated with nav1.3, nerve growth factor, nav1.8 and nav1.9
2) Confidence 0.45 Published 2003 Journal J. Neurosci. Res. Section Abstract Doc Link 14515348 Disease Relevance 0.24 Pain Relevance 1.33
We examined the effect of electrical stimulation on the expression of Nav1.3, Nav1.8, and Nav1.9 by using cultured embryonic mouse sensory neurons under conditions in which nerve growth factor (NGF) was not limiting.
Spec (examined) Regulation (effect) of Gene_expression (expression) of Nav1 in nerve associated with nav1.3, nerve growth factor, nav1.8 and nav1.9
3) Confidence 0.45 Published 2003 Journal J. Neurosci. Res. Section Abstract Doc Link 14515348 Disease Relevance 0.24 Pain Relevance 1.34
The expression of Nav1.8 in cultured Purkinje cells has been shown to alter the activity pattern of these cells in vitro by decreasing the number of spikes per conglomerate action potential and by contributing to the production of sustained, pacemaker-like activity upon depolarization, suggesting the hypothesis that, in pathophysiological situations where Nav1.8 is upregulated within Purkinje cells, the pattern of activity in these cells will be altered.
Regulation (alter) of Gene_expression (expression) of Nav1 in Purkinje cells associated with action potential and nav1.8
4) Confidence 0.45 Published 2004 Journal Exp Brain Res Section Abstract Doc Link 15118796 Disease Relevance 0.60 Pain Relevance 0.51
These observations prompted us to test whether the absence of dystrophin could alter the expression and function of Nav1.4, and whether the changes can account for the increase in [Na+]i (Dunn et al., 1993; Allen, 2004).
Regulation (alter) of Gene_expression (expression) of Nav1
5) Confidence 0.44 Published 2008 Journal The Journal of General Physiology Section Body Doc Link PMC2483333 Disease Relevance 0.06 Pain Relevance 0.16
Work is in progress to assess the role and the distribution of Nav1.5, as well as the interaction of ?
Regulation (role) of Gene_expression (distribution) of Nav1
6) Confidence 0.44 Published 2008 Journal The Journal of General Physiology Section Body Doc Link PMC2483333 Disease Relevance 0 Pain Relevance 0
This motif plays a critical role in regulating Nav1.4 expression through binding to a complex of proteins (Kraner et al., 1998).
Regulation (regulating) of Gene_expression (expression) of Nav1
7) Confidence 0.44 Published 2008 Journal The Journal of General Physiology Section Body Doc Link PMC2483333 Disease Relevance 0.18 Pain Relevance 0
Nav1.9 mRNA level has been shown to increase by day 7 with CFA-induced inflammation [26]; however, its expression was not changed in our CFA model.
Neg (not) Regulation (changed) of Gene_expression (expression) of Nav1 associated with inflammation and nav1.9
8) Confidence 0.44 Published 2009 Journal Mol Pain Section Body Doc Link PMC2632618 Disease Relevance 1.04 Pain Relevance 1.25
Consistent with these results, we have demonstrated a reduction in Nav1.8 and Nav1.9 immunostaining on peripherin-positive unmyelinated axons in sciatic nerves from CNTN-/- mice but detected no changes in the expression for the two major TTX-S channels Nav1.6 and Nav1.7.
Neg (no) Regulation (changes) of Gene_expression (expression) of Nav1 in sciatic nerves associated with sciatic nerve, nav1.8, nav1.7, nav1.6, unmyelinated and nav1.9
9) Confidence 0.44 Published 2005 Journal Eur. J. Neurosci. Section Abstract Doc Link 16029194 Disease Relevance 0.37 Pain Relevance 1.31
Nav1.2 levels in mossy fibers do not correlate with seizure phenotype
Neg (not) Regulation (correlate) of Gene_expression (levels) of Nav1 in mossy fibers associated with convulsion and nav1.2
10) Confidence 0.42 Published 2010 Journal Mol Neurodegener Section Body Doc Link PMC2933677 Disease Relevance 0.32 Pain Relevance 0.62
Thus, while there is large variation across the BACE1-/- mouse population in seizure susceptibility as well as in Nav1.2 expression and axonal localization, our results find no correlation of these measures and do not support the hypothesis that altered Nav1.2 expression or localization underlies the hyperexcitability phenotype of BACE1-/- mice.
Regulation (altered) of Gene_expression (expression) of Nav1 associated with convulsion, nav1.2 and hyperexcitability
11) Confidence 0.42 Published 2010 Journal Mol Neurodegener Section Body Doc Link PMC2933677 Disease Relevance 0.68 Pain Relevance 0.64
Among the molecular drivers are ion channels (Nav1.7, Nav1.8, Nav1.3, Cav2.2, and alpha2-delta subunits) whose expression is changed during neuropathic pain and their block shows therapeutic utility.
Regulation (changed) of Gene_expression (expression) of Nav1 associated with nav1.3, neuropathic pain, nav1.8 and nav1.7
12) Confidence 0.36 Published 2008 Journal Br J Anaesth Section Abstract Doc Link 18511441 Disease Relevance 0.44 Pain Relevance 0.70
Among the molecular drivers are ion channels (Nav1.7, Nav1.8, Nav1.3, Cav2.2, and alpha2-delta subunits) whose expression is changed during neuropathic pain and their block shows therapeutic utility.
Regulation (changed) of Gene_expression (expression) of Nav1 associated with nav1.3, neuropathic pain, nav1.8 and nav1.7
13) Confidence 0.36 Published 2008 Journal Br J Anaesth Section Abstract Doc Link 18511441 Disease Relevance 0.44 Pain Relevance 0.70
The goal of the present study was to investigate the possible role of changes in Nav1.6 expression in abnormal, activity-dependent plasticity of hippocampal circuits.
Spec (investigate) Regulation (changes) of Gene_expression (expression) of Nav1 associated with nav1.6
14) Confidence 0.27 Published 2009 Journal Epilepsia Section Abstract Doc Link 18637833 Disease Relevance 0.08 Pain Relevance 0.53
These measures are indicative of central sensitisation and neuronal hyperexcitability, and since Nav 1.8 is not expressed within the spinal cord, its deletion should not affect these measures, as we have shown.
Neg (not) Regulation (affect) of Neg (not) Gene_expression (expressed) of Nav in neuronal associated with hyperexcitability and spinal cord
15) Confidence 0.27 Published 2006 Journal Mol Pain Section Body Doc Link PMC1403745 Disease Relevance 0.13 Pain Relevance 0.52
To avoid possible changes in the expression levels of Nav1.4 channels following fiber isolation, measurements were performed within a few hours after harvesting the cells.
Spec (possible) Regulation (changes) of Gene_expression (expression) of Nav1
16) Confidence 0.26 Published 2008 Journal The Journal of General Physiology Section Body Doc Link PMC2483333 Disease Relevance 0 Pain Relevance 0.06
Consistent with these results, we have demonstrated a reduction in Nav1.8 and Nav1.9 immunostaining on peripherin-positive unmyelinated axons in sciatic nerves from CNTN-/- mice but detected no changes in the expression for the two major TTX-S channels Nav1.6 and Nav1.7.
Neg (no) Regulation (changes) of Gene_expression (expression) of Nav1 in sciatic nerves associated with sciatic nerve, nav1.8, nav1.7, nav1.6, unmyelinated and nav1.9
17) Confidence 0.26 Published 2005 Journal Eur. J. Neurosci. Section Abstract Doc Link 16029194 Disease Relevance 0.37 Pain Relevance 1.31
These mutations are all in highly conserved amino acids and are postulated to alter the function of brain-expressed Nav1.7.
Spec (postulated) Regulation (alter) of Gene_expression (expressed) of Nav1.7 in brain associated with nav1.7
18) Confidence 0.26 Published 2010 Journal Human Mutation Section Body Doc Link PMC2966863 Disease Relevance 1.53 Pain Relevance 0.70
The surface expression of NaV1.8 in sensory neurons may be regulated by similar machinery involving Pdzd2 and its other binding partners through its remaining PDZ domains.
Spec (may) Regulation (regulated) of Gene_expression (expression) of NaV1 in sensory neurons
19) Confidence 0.25 Published 2009 Journal Mol Cell Neurosci Section Body Doc Link PMC2764382 Disease Relevance 0.25 Pain Relevance 0.16
Antillatoxin is a sodium channel activator that displays unique efficacy in heterologously expressed rNav1.2, rNav1.4 and rNav1.5 alpha subunits

Background

Regulation (efficacy) of Gene_expression (expressed) of rNav1 associated with sodium channel
20) Confidence 0.23 Published 2010 Journal BMC Neurosci Section Title Doc Link PMC3009643 Disease Relevance 0 Pain Relevance 0.27

General Comments

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