INT113385

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Context Info
Confidence 0.43
First Reported 2003
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 0.73
Pain Relevance 2.74

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Nav1) cytoskeleton (Nav1) cytoplasm (Nav1)
Anatomy Link Frequency
nociceptor 2
Nav1 (Mus musculus)
Pain Link Frequency Relevance Heat
nav1.8 7 100.00 Very High Very High Very High
Nav1.9 3 100.00 Very High Very High Very High
nociceptor 7 99.66 Very High Very High Very High
nav1.3 3 95.88 Very High Very High Very High
Nerve growth factor 3 94.28 High High
IPN 3 88.44 High High
sodium channel 6 85.40 High High
Spinal cord 1 85.20 High High
Dorsal horn 1 84.44 Quite High
Inflammatory mediators 1 79.56 Quite High
Disease Link Frequency Relevance Heat
Inflammatory Pain 3 88.44 High High
INFLAMMATION 1 79.16 Quite High
Pain 3 75.04 Quite High
Neuropathic Pain 1 72.16 Quite High
Ganglion Cysts 1 67.12 Quite High
Nervous System Injury 1 62.20 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In contrast, we observed activity-dependent down-regulation of Nav1.8 and Nav1.9 mRNA and protein levels after stimulation, as demonstrated by quantitative polymerase chain reaction and immunocytochemistry.
Negative_regulation (regulation) of Transcription (levels) of Nav1 associated with nav1.8 and nav1.9
1) Confidence 0.43 Published 2003 Journal J. Neurosci. Res. Section Abstract Doc Link 14515348 Disease Relevance 0.20 Pain Relevance 1.30
By contrast, nociceptor-associated mRNA transcripts (e.g., Nav1.8, P2xr3, and Runx-1) were downregulated, resulting in lower levels of protein and functional expression. qRT-PCR analysis also showed lowered levels of expression of nociceptor-specific pre-mRNA transcripts.
Negative_regulation (downregulated) of Transcription (transcripts) of Nav1 in nociceptor associated with nociceptor and nav1.8
2) Confidence 0.43 Published 2010 Journal J. Neurosci. Section Abstract Doc Link 20702715 Disease Relevance 0.53 Pain Relevance 1.44

General Comments

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