INT113398

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Context Info
Confidence 0.19
First Reported 1998
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 1.64
Pain Relevance 1.14

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Pla2g2a) extracellular space (Pla2g2a) endoplasmic reticulum (Pla2g2a)
Pla2g2a (Mus musculus)
Pain Link Frequency Relevance Heat
metalloproteinase 29 99.00 Very High Very High Very High
fibrosis 1 96.28 Very High Very High Very High
Chronic pancreatitis 7 93.96 High High
Inflammation 51 90.60 High High
cytokine 8 86.12 High High
Nerve growth factor 7 83.52 Quite High
antagonist 1 77.92 Quite High
Inflammatory mediators 1 75.00 Quite High
Eae 2 64.32 Quite High
Hippocampus 9 62.32 Quite High
Disease Link Frequency Relevance Heat
Metaplasia 3 99.52 Very High Very High Very High
Fibrosis 1 96.28 Very High Very High Very High
Pancreatitis 7 93.96 High High
Stroke 1 93.68 High High
INFLAMMATION 57 90.60 High High
Disease 127 82.24 Quite High
Coagulation Disorder 9 65.28 Quite High
Cognitive Disorder 50 55.44 Quite High
Targeted Disruption 7 45.40 Quite Low
Urological Neuroanatomy 1 38.40 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Increased PLA2-II and PLA2-IV mRNA levels were associated with a higher degree of tissue destruction, ductal metaplasia and degree of fibrosis.
Transcription (levels) of PLA2-II associated with fibrosis and metaplasia
1) Confidence 0.19 Published 1998 Journal Langenbecks Arch Chir Suppl Kongressbd Section Abstract Doc Link 14518291 Disease Relevance 0.95 Pain Relevance 0.70
PLA2 abundance was similar to B. insularis, greater than B. jararaca but less than B. atrox and B. jararacussu; the latter species was the only one in which PLA2 transcripts were more abundant than metalloproteinases (at least two-fold greater).
Transcription (transcripts) of PLA2 associated with metalloproteinase
2) Confidence 0.12 Published 2010 Journal BMC Genomics Section Body Doc Link PMC3017861 Disease Relevance 0.07 Pain Relevance 0.17
-induced sPLA2-IIA mRNA expression, ERK1/2 activation, and translocation of the NADPH oxidase subunit p67 phox from cytosol to membrane fraction [94].
Transcription (expression) of sPLA2-IIA
3) Confidence 0.05 Published 2010 Journal Mol Neurobiol Section Body Doc Link PMC2876259 Disease Relevance 0.62 Pain Relevance 0.26

General Comments

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