INT113399

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Context Info
Confidence 0.67
First Reported 1998
Last Reported 2010
Negated 1
Speculated 1
Reported most in Body
Documents 36
Total Number 37
Disease Relevance 33.83
Pain Relevance 18.78

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Pla2g4a) Golgi apparatus (Pla2g4a) endoplasmic reticulum (Pla2g4a)
nucleus (Pla2g4a) cytoplasm (Pla2g4a)
Anatomy Link Frequency
neurons 4
macrophages 2
nerve 2
spinal cord 2
peripheral nerve 2
Pla2g4a (Mus musculus)
Pain Link Frequency Relevance Heat
Peripheral nerve injury 151 99.82 Very High Very High Very High
agonist 76 99.82 Very High Very High Very High
dorsal root ganglion 1049 99.72 Very High Very High Very High
Glutamate 4 99.68 Very High Very High Very High
Brush evoked pain 528 99.52 Very High Very High Very High
Analgesic 74 99.44 Very High Very High Very High
Chronic pancreatitis 14 99.40 Very High Very High Very High
substance P 22 99.38 Very High Very High Very High
Neuropathic pain 241 99.22 Very High Very High Very High
Pain 145 99.04 Very High Very High Very High
Disease Link Frequency Relevance Heat
Shock 17 100.00 Very High Very High Very High
Targeted Disruption 131 99.96 Very High Very High Very High
Stress 12 99.96 Very High Very High Very High
Metaplasia 6 99.92 Very High Very High Very High
Disease 426 99.84 Very High Very High Very High
Nervous System Injury 701 99.82 Very High Very High Very High
Ganglion Cysts 1062 99.72 Very High Very High Very High
Neuropathic Pain 889 99.52 Very High Very High Very High
Pancreatitis 14 99.40 Very High Very High Very High
Motor Neuron Diseases 14 99.26 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This is in agreement with previous studies reporting that epithelial cells from CF patients release more AA than control cells and express higher levels of cPLA2?
Positive_regulation (levels) of cPLA2 in epithelial cells associated with fibrosis
1) Confidence 0.67 Published 2010 Journal Respir Res Section Body Doc Link PMC2873258 Disease Relevance 0.19 Pain Relevance 0.12
Immunohistochemistry and real-time RT-PCR revealed elevated cPLA2 protein and its mRNA levels in the lumbar spinal cord of mutant SOD1 mice.
Positive_regulation (elevated) of cPLA2 protein in spinal cord associated with spinal cord
2) Confidence 0.64 Published 2005 Journal J. Neurochem. Section Abstract Doc Link 15816863 Disease Relevance 0.91 Pain Relevance 0.27
COX-2 immunoreactivity was increased in lumbar spinal cord sections from both familial ALS (FALS) and sporadic ALS (SALS) as compared to controls, and cPLA2 immunoreactivity was increased in a patient with FALS.
Positive_regulation (increased) of cPLA2 in spinal cord associated with motor neuron diseases and spinal cord
3) Confidence 0.55 Published 2005 Journal J. Neurochem. Section Abstract Doc Link 15816863 Disease Relevance 1.03 Pain Relevance 0.34
, recent studies in our laboratory suggested that cPLA2?
Positive_regulation (suggested) of cPLA2
4) Confidence 0.49 Published 2010 Journal Respir Res Section Body Doc Link PMC2873258 Disease Relevance 0.51 Pain Relevance 0.16
Stimulating P2X4R in macrophages triggers calcium influx and p38 MAPK phosphorylation, resulting in cytosolic PLA2 (cPLA2) activation and COX-dependent release of PGE2.
Positive_regulation (activation) of cPLA2 in macrophages
5) Confidence 0.43 Published 2010 Journal EMBO J. Section Abstract Doc Link 20562826 Disease Relevance 1.12 Pain Relevance 0.85
On the other hand, the activities of cytosolic phospholipase A2 (cPLA2) and calcium-independent phospholipase A2 (iPLA2) were enhanced, with peaks at 1 h after injury.
Positive_regulation (enhanced) of cytosolic phospholipase A2 associated with injury
6) Confidence 0.42 Published 2010 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 20123931 Disease Relevance 1.20 Pain Relevance 0.60
Furthermore VEGF levels were found to be significantly elevated when both cPLA2 and COX-2 were expressed.
Positive_regulation (elevated) of cPLA2
7) Confidence 0.40 Published 2010 Journal Yonsei Medical Journal Section Body Doc Link PMC2908865 Disease Relevance 1.41 Pain Relevance 0
Stimulating P2X4R in macrophages triggers calcium influx and p38 MAPK phosphorylation, resulting in cytosolic PLA2 (cPLA2) activation and COX-dependent release of PGE2.
Positive_regulation (activation) of cytosolic PLA2 in macrophages
8) Confidence 0.38 Published 2010 Journal EMBO J. Section Abstract Doc Link 20562826 Disease Relevance 1.12 Pain Relevance 0.86
Therefore, intense pain-signals after nerve-injury may induce an excess release of pain transmitters, SP, and glutamate, which in turn activate both cPLA2 and iPLA2 through different pathways (Fig. 3).
Positive_regulation (activate) of cPLA2 in nerve associated with pain, glutamate, injury and substance p
9) Confidence 0.36 Published 2008 Journal Mol Pain Section Body Doc Link PMC2365930 Disease Relevance 0.85 Pain Relevance 0.74
We found that COX-2-/- mice have altered expression and activity of enzymes in the AA metabolism cascade, including increases in COX-1, cytosolic phospholipase A2 (cPLA2) and secretory phospholipase A2 expression [5].
Positive_regulation (increases) of cPLA2
10) Confidence 0.32 Published 2007 Journal Genome Biol Section Body Doc Link PMC1839133 Disease Relevance 0.07 Pain Relevance 0.11
Recent studies revealed that phosphatidyl choline is converted to LPC by cytosolic phospholipase A2 (cPLA2) or calcium-independent PLA2 (iPLA2), both of which are regulated by Ca2+-related mechanisms. cPLA2 is activated through membrane translocation, which is stimulated by Ca2+ or phosphorylation by mitogen-activated kinase (MAPK) or PKCs [76-78], while iPLA2 is activated through the removal of calmodulin by calcium influx factor (CIF) produced after Ca2+ depletion in the endoplasmic reticulum [79,80].
Positive_regulation (activated) of cPLA2 in reticulum
11) Confidence 0.26 Published 2008 Journal Mol Pain Section Body Doc Link PMC2365930 Disease Relevance 0.90 Pain Relevance 0.75
First, we examined whether DRG neurons with activated cPLA2 express the lyso-PAF-acetyltransferase LPCAT2, a critical enzyme that produces PAF [32], [33], [34].
Spec (whether) Positive_regulation (activated) of cPLA2 in neurons associated with dorsal root ganglion
12) Confidence 0.24 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2862737 Disease Relevance 1.43 Pain Relevance 0.90
Furthermore, DRG neurons with activated cPLA2 also expressed the lyso-PAF-acetyltransferase LPCAT2, a critical enzyme that produces PAF [32], [33], [34].
Positive_regulation (activated) of cPLA2 in neurons associated with dorsal root ganglion
13) Confidence 0.24 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2862737 Disease Relevance 1.67 Pain Relevance 1.22
These results suggest that LPCAT2 and activated cPLA2 are co-expressed in the injured DRG.
Positive_regulation (activated) of cPLA2 associated with dorsal root ganglion
14) Confidence 0.24 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2862737 Disease Relevance 1.44 Pain Relevance 0.78
It also indicates that the contribution of CERK/C1P to cPLA2 function might be best evidenced when cPLA2 is sub-optimally activated.
Positive_regulation (activated) of cPLA2
15) Confidence 0.23 Published 2010 Journal Lipids Health Dis Section Body Doc Link PMC2817648 Disease Relevance 0.48 Pain Relevance 0.11
Unlike conventional NSAIDs that inhibit COX, DHA can competitively reduce CNS levels of AA and, therefore, reduce enzymatic metabolites via COX and LOXs (prostaglandins (PGs) and the leukotrienes like hydroxyeicosatetraenoic acids (HETES), respectively) that are increased by elevated cPLA2.
Positive_regulation (elevated) of cPLA2 associated with cinod
16) Confidence 0.19 Published 2010 Journal Mol Neurobiol Section Body Doc Link PMC2876259 Disease Relevance 0.76 Pain Relevance 0.55
This results in downstream activation of cPLA2 and release of the prostaglandin precursor arachadonic acid, a potential substrate for COX-2 now known to be induced as an important element of p53 inhibition by MIF.
Positive_regulation (activation) of cPLA2
17) Confidence 0.18 Published 2010 Journal QJM: An International Journal of Medicine Section Body Doc Link PMC2955282 Disease Relevance 1.00 Pain Relevance 0
We have previously shown that peripheral nerve injury induces activation of cytosolic phospholipase A2 (cPLA2) in injured dorsal root ganglion (DRG) neurons that contribute to tactile allodynia, a hallmark of neuropathic pain.
Positive_regulation (activation) of cPLA2 in peripheral nerve associated with ganglion cysts, brush evoked pain, dorsal root ganglion, nervous system injury, neuropathic pain and peripheral nerve injury
18) Confidence 0.16 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2862737 Disease Relevance 1.24 Pain Relevance 1.01
Activity of voltage-gated Ca2+ channels (VDCC) is also involved in cPLA2 activation [61].
Positive_regulation (activation) of cPLA2
19) Confidence 0.16 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2862737 Disease Relevance 1.13 Pain Relevance 0.67
In the present study, to determine the neuropathic pain-related lipid mediators downstream of cPLA2 activation in the DRG, we investigate the involvement of enzymes and lipid mediator receptors in nerve injury-induced tactile allodynia using pharmacological, molecular, and genetic approaches.
Positive_regulation (activation) of cPLA2 in nerve associated with brush evoked pain, dorsal root ganglion, nervous system injury and neuropathic pain
20) Confidence 0.16 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2862737 Disease Relevance 1.41 Pain Relevance 0.94

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