INT11340

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Context Info
Confidence 0.67
First Reported 1987
Last Reported 2010
Negated 7
Speculated 2
Reported most in Body
Documents 120
Total Number 122
Disease Relevance 113.52
Pain Relevance 14.50

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasmic membrane-bounded vesicle (SLC17A5) plasma membrane (SLC17A5) transmembrane transport (SLC17A5)
Anatomy Link Frequency
liver 16
blood 6
plasma 4
kidney 3
muscle 2
SLC17A5 (Homo sapiens)
Pain Link Frequency Relevance Heat
pulpitis 7 99.70 Very High Very High Very High
headache 72 99.68 Very High Very High Very High
Paracetamol 264 99.62 Very High Very High Very High
Inflammation 290 99.32 Very High Very High Very High
abdominal pain 80 99.20 Very High Very High Very High
depression 107 98.86 Very High Very High Very High
fibrosis 98 98.56 Very High Very High Very High
Pain 100 98.48 Very High Very High Very High
Glutamate 7 97.80 Very High Very High Very High
Angina 20 97.76 Very High Very High Very High
Disease Link Frequency Relevance Heat
Dengue 1007 100.00 Very High Very High Very High
Infection 855 100.00 Very High Very High Very High
Disorders Of Creatine Metabolism 43 100.00 Very High Very High Very High
Hyperbilirubinemia 7 100.00 Very High Very High Very High
Cholangitis 39 99.98 Very High Very High Very High
Hepatotoxicity 253 99.96 Very High Very High Very High
Vomiting 166 99.96 Very High Very High Very High
Jaundice 153 99.96 Very High Very High Very High
Thrombocytopenia 106 99.96 Very High Very High Very High
Congenital Anomalies 90 99.96 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The incidence of non-A, non-B hepatitis, as estimated by unexplained elevations in serum aspartate aminotransferase (AST) values, was not different between patients receiving and not receiving blood transfusions.
Positive_regulation (elevations) of AST in blood associated with hepatitis
1) Confidence 0.67 Published 1992 Journal Am. J. Kidney Dis. Section Abstract Doc Link 1553966 Disease Relevance 1.31 Pain Relevance 0.09
In clinical trials, the ETRA bosentan causes elevation of liver aminotransferases (ALT and AST) >3 × ULN in about 11% of patients, accompanied by elevated bilirubin in a small number of cases (Actellion 2004).
Positive_regulation (elevation) of AST in liver
2) Confidence 0.67 Published 2007 Journal Vascular Health and Risk Management Section Body Doc Link PMC1994033 Disease Relevance 0.38 Pain Relevance 0.04
Laboratory abnormalities may include anemia, leukopenia, thrombocytopenia, increased AST/ALT levels, and prolonged prothrombin, bleeding, and activated partial thromboplastin times.
Spec (partial) Positive_regulation (increased) of AST associated with anaemia, leukopenia, congenital anomalies, hemorrhage and thrombocytopenia
3) Confidence 0.67 Published 2007 Journal Arch Iran Med Section Abstract Doc Link 17367225 Disease Relevance 1.66 Pain Relevance 0.18
Electrocardiogram indicated the elevation of ST-T levels and low voltage, and blood examination showed remarkable elevation of creatine phosphokinase (CK), white blood cell count (WBC), aspartate aminotransferase (AST) and lactic dehydrogenase (LDH) levels.
Positive_regulation (elevation) of AST in blood associated with disorders of creatine metabolism
4) Confidence 0.67 Published 2002 Journal Nihon Rinsho Meneki Gakkai Kaishi Section Abstract Doc Link 12043186 Disease Relevance 0.89 Pain Relevance 0.09
We experienced transient increases of AST/ALT in a few cases, subcutaneous emphysema in one case, pleural effusion and ascites in two cases, but conservative treatments were effective for all cases.
Positive_regulation (increases) of AST associated with pleural effusion, pressure and volume under development and subcutaneous emphysema
5) Confidence 0.67 Published 2001 Journal Gan To Kagaku Ryoho Section Abstract Doc Link 11707986 Disease Relevance 0.63 Pain Relevance 0.10
In addition, clinical chemistry revealed a significant increase in serum aspartate aminotransferases (AST) and alanine aminotransferases (ALT) following PH and PH/TIPS.
Positive_regulation (increase) of AST
6) Confidence 0.67 Published 2007 Journal Comp Hepatol Section Body Doc Link PMC1920532 Disease Relevance 0.31 Pain Relevance 0.03
The biochemical findings revealed a significantly higher concentration of total serum globulins and sodium, and increased activity, in CK, LDH and AST.
Positive_regulation (increased) of AST
7) Confidence 0.67 Published 1999 Journal J S Afr Vet Assoc Section Abstract Doc Link 10855843 Disease Relevance 0.47 Pain Relevance 0.15
Serum aspartate aminotransferase (AST) and aldolase were mildly elevated.
Positive_regulation (elevated) of AST
8) Confidence 0.67 Published 1999 Journal Nervenarzt Section Abstract Doc Link 10412700 Disease Relevance 1.06 Pain Relevance 0.21
Actually, in the high dose group (DOX applied at 20 mg/kg), the concentration of ALT and AST showed significant increase in blood 24 h after administration; ALT, AST and CK increased 48 h after dosing, and finally all parameters changed significantly 96 h after dosing.
Positive_regulation (increase) of AST in blood
9) Confidence 0.67 Published 2009 Journal Metabolomics Section Body Doc Link PMC2794350 Disease Relevance 0.15 Pain Relevance 0
Significant toxicities included edema and elevated serum aspartate aminotransferase (AST).
Positive_regulation (elevated) of AST associated with pressure and volume under development
10) Confidence 0.67 Published 1997 Journal Clin. Cancer Res. Section Abstract Doc Link 9815786 Disease Relevance 0.73 Pain Relevance 0
Moreover, the present study suggested that grade 1/2 liver dysfunction (elevated AST, ALT, ALP, ?
Positive_regulation (elevated) of AST in liver associated with hepatotoxicity
11) Confidence 0.67 Published 2008 Journal Cancer Chemother Pharmacol Section Body Doc Link PMC2688618 Disease Relevance 0.94 Pain Relevance 0.09
The diagnosis of acute cholangitis requires a white blood cell count; measurement of the C-reactive protein level; and liver function tests, including alkaline phosphatase, gamma-glutamyltranspeptidase (GGT), aspartate aminotransferase (AST), alanine aminotransferase (ALT), and bilirubin.
Positive_regulation (requires) of AST in liver associated with cholangitis
12) Confidence 0.49 Published 2007 Journal J Hepatobiliary Pancreat Surg Section Body Doc Link PMC2784508 Disease Relevance 2.00 Pain Relevance 0.24
Laboratory studies show that serum aminotransferase abnormalities are rather moderate, with serum alanine aminotransferase (ALT) more elevated than serum aspartate aminotransferase (AST).
Positive_regulation (elevated) of AST associated with congenital anomalies
13) Confidence 0.49 Published 2005 Journal Front. Biosci. Section Abstract Doc Link 15970496 Disease Relevance 1.81 Pain Relevance 0.14
Similarly, Chang et al. reported that a high Aspartate transaminase (AST)/alanine transaminase (ALT) ratio in late disease is associated with death.[28] Bleeding diathesis was reported as a mortality indicator by Covic et al.[45]
Positive_regulation (high) of AST associated with coagulation disorder, disease and death
14) Confidence 0.49 Published 2010 Journal Journal of Emergencies, Trauma and Shock Section Body Doc Link PMC2938484 Disease Relevance 1.61 Pain Relevance 0
stimulating hormone (TSH), alkaline phosphatase, aspartate aminotransferase (AST), alanine aminotranferase (ALT) and urinary excretion of sodium in 24 h.


Positive_regulation (stimulating) of AST
15) Confidence 0.49 Published 2010 Journal Clinics (Sao Paulo) Section Body Doc Link PMC2974815 Disease Relevance 0.51 Pain Relevance 0.06
DMN-induced increases in serum AST, ALT and ALP levels were significantly suppressed by grape skin or seeds feeding.
Positive_regulation (increases) of AST in skin
16) Confidence 0.49 Published 2010 Journal Nutrition Research and Practice Section Body Doc Link PMC2981719 Disease Relevance 0.38 Pain Relevance 0
In this study, DMN-induced increase in serum AST, ALT, ALP levels was significantly suppressed by grape skin or seeds ingestion.
Positive_regulation (increase) of AST in skin
17) Confidence 0.49 Published 2010 Journal Nutrition Research and Practice Section Body Doc Link PMC2981719 Disease Relevance 0.89 Pain Relevance 0.28
Only grade I to II nonhematologic toxicities, including two abdominal pain of grade II, one fever of grade I, and one AST/ALT elevation of grade I, were observed.
Positive_regulation (elevation) of AST associated with abdominal pain and fever
18) Confidence 0.49 Published 2005 Journal Yonsei Medical Journal Section Body Doc Link PMC2810594 Disease Relevance 1.10 Pain Relevance 0.17
In reversible pulpitis specimens the AST activity increased to 7.98 +/- 2.1 units/mg of pulp tissue.
Positive_regulation (increased) of AST associated with pulpitis
19) Confidence 0.46 Published 2001 Journal J Endod Section Abstract Doc Link 11487132 Disease Relevance 0.88 Pain Relevance 0.75
A recent study of 504 patients, in which patients with baseline abnormal liver enzymes were excluded, showed no clinically significant alanine aminotransferase (ALT) and aspartate aminotransferase (AST) elevation in plasma levels when tested 6 weeks into the treatment (250 mg/day) (Pollak et al 2004).
Neg (no) Positive_regulation (elevation) of AST in plasma
20) Confidence 0.45 Published 2005 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC1661633 Disease Relevance 0.73 Pain Relevance 0

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