INT113415

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Context Info
Confidence 0.28
First Reported 2003
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 8
Total Number 8
Disease Relevance 1.62
Pain Relevance 2.07

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
neuronal 2
gp (Mus musculus)
Pain Link Frequency Relevance Heat
Gabapentin 13 100.00 Very High Very High Very High
withdrawal 4 99.52 Very High Very High Very High
alcohol 5 99.30 Very High Very High Very High
Substantia nigra 12 97.04 Very High Very High Very High
gABA 13 96.24 Very High Very High Very High
agonist 37 94.52 High High
GABAergic 33 94.44 High High
Pain score 10 80.72 Quite High
Pain 30 74.64 Quite High
Dopamine 45 73.44 Quite High
Disease Link Frequency Relevance Heat
Alcohol Addiction 4 99.52 Very High Very High Very High
Alagille Syndrome 7 98.88 Very High Very High Very High
Catalepsy 82 91.80 High High
Disease 69 87.52 High High
Hypokinesia 17 85.52 High High
Pain 40 80.72 Quite High
Osteoarthritis 10 57.96 Quite High
Parkinson's Disease 22 41.00 Quite Low
Opiate Addiction 1 37.88 Quite Low
Injury 20 23.60 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Complaints that were presented to the GP for the first time, and recurrent complaints for which the GP was not consulted during the preceding 3 months, were considered to be new complaints.
Neg (not) Positive_regulation (consulted) of GP
1) Confidence 0.28 Published 2008 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2278141 Disease Relevance 0.07 Pain Relevance 0.07
Analyses showed that revisiting GP is more dependent on age and functional disability at baseline than on being an athlete or not.
Positive_regulation (dependent) of GP
2) Confidence 0.23 Published 2008 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2278141 Disease Relevance 0.14 Pain Relevance 0.11
All together, GP (400 mg qid) was no better than P in saving initial consumption of CLO or decreasing initial Mainz Alcohol Withdrawal Scores suggesting that GP was ineffective in the management of acute AWS in this model.
Positive_regulation (ineffective) of GP associated with alagille syndrome, withdrawal, gabapentin and alcohol
3) Confidence 0.06 Published 2003 Journal J Clin Psychopharmacol Section Abstract Doc Link 14520131 Disease Relevance 0.55 Pain Relevance 1.10
These results represent additional evidence for neuroleptic-induced increase of the GP neuronal activity in agreement with other studies using quantitative in situ hybridization of GAD67 mRNA expression, which is an index of GABAergic activity [42].
Positive_regulation (increase) of GP in neuronal associated with gabaergic
4) Confidence 0.03 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2704377 Disease Relevance 0 Pain Relevance 0.18
Moreover, our study provides new insight into the role of GP, which is a key structure of the indirect pathway, in the pathophysiology of APD-induced EPS and that GP can be considered as a potential target for the treatment of EPS.



Positive_regulation (induced) of GP
5) Confidence 0.03 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2704377 Disease Relevance 0.31 Pain Relevance 0
Moreover, we add evidence that the changes in STN neuronal activity could originate in the GP as we show that ?
Positive_regulation (originate) of GP in neuronal
6) Confidence 0.02 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2704377 Disease Relevance 0 Pain Relevance 0.11
These results are in line with previous studies showing that inactivation of the GP can elicit motor activation or reverse motor hypoactivity.
Positive_regulation (inactivation) of GP
7) Confidence 0.02 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2704377 Disease Relevance 0.40 Pain Relevance 0.16
Again, a role for mGlu7 receptors in the GP awaits verification.


Positive_regulation (role) of GP
8) Confidence 0.01 Published 2010 Journal British Journal of Pharmacology Section Body Doc Link PMC2989582 Disease Relevance 0.15 Pain Relevance 0.34

General Comments

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