INT113420

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Context Info
Confidence 0.69
First Reported 2003
Last Reported 2011
Negated 2
Speculated 2
Reported most in Body
Documents 22
Total Number 26
Disease Relevance 19.96
Pain Relevance 5.53

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (IL18) extracellular space (IL18) extracellular region (IL18)
cell-cell signaling (IL18) cytoplasm (IL18)
Anatomy Link Frequency
endothelial cells 8
plaque 6
articular 2
temporal artery 2
endothelium 2
IL18 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 511 100.00 Very High Very High Very High
Arthritis 72 99.46 Very High Very High Very High
Inflammation 515 98.72 Very High Very High Very High
rheumatoid arthritis 303 97.38 Very High Very High Very High
metalloproteinase 26 94.80 High High
methotrexate 18 92.52 High High
depression 3 88.76 High High
chemokine 88 88.60 High High
Osteoarthritis 41 87.08 High High
Inflammatory stimuli 6 79.20 Quite High
Disease Link Frequency Relevance Heat
Asthma 636 100.00 Very High Very High Very High
Adhesions 91 100.00 Very High Very High Very High
Atherosclerotic Plaque 19 100.00 Very High Very High Very High
Cancer 117 99.80 Very High Very High Very High
Experimental Arthritis 13 99.64 Very High Very High Very High
Necrosis 44 99.56 Very High Very High Very High
Mucocutaneous Lymph Node Syndrome 50 99.16 Very High Very High Very High
Obesity 39 99.04 Very High Very High Very High
INFLAMMATION 600 98.72 Very High Very High Very High
Increased Venous Pressure Under Development 173 98.72 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Interestingly, Nabili et al. [56] reported and increased expression of IL18 in temporal artery biopsies of GCA patients, with no correlation with clinical manifestations or hematologic parameters.
Positive_regulation (increased) of Gene_expression (expression) of IL18 in temporal artery associated with increased venous pressure under development
1) Confidence 0.69 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2888200 Disease Relevance 0.97 Pain Relevance 0.17
C-reactive protein-induced production of interleukin-18 in human endothelial cells: a mechanism of orchestrating cytokine cascade in acute coronary syndrome.
Positive_regulation (protein-induced) of Gene_expression (production) of interleukin-18 in endothelial cells associated with acute coronary syndrome and cytokine
2) Confidence 0.50 Published 2003 Journal Heart Vessels Section Title Doc Link 14520485 Disease Relevance 0.71 Pain Relevance 0.19
To determine the mechanism of accelerating IL-18 production, we examined the release of IL-18 in human endothelial cells using human recombinant (hr) C-reactive protein (CRP) as a stimulator of IL-18.
Spec (determine) Positive_regulation (accelerating) of Gene_expression (production) of IL-18 in endothelial cells
3) Confidence 0.50 Published 2003 Journal Heart Vessels Section Abstract Doc Link 14520485 Disease Relevance 0.74 Pain Relevance 0.20
Quantitative competitive PCR demonstrated that endometrial IL-18R mRNA and the ratio of IL-18BP to IL-18 were significantly increased in adenomyosis patients in comparison to the control group.
Positive_regulation (increased) of Gene_expression (ratio) of IL-18
4) Confidence 0.48 Published 2010 Journal Fertil. Steril. Section Body Doc Link 19394601 Disease Relevance 0.06 Pain Relevance 0
These results highlighted TWEAK and IL-18 expression are independent one from the other in human endometrium but are both regulated via a Map Kinase pathway.


Neg (independent) Positive_regulation (independent) of Gene_expression (expression) of IL-18 in endometrium
5) Confidence 0.45 Published 2011 Journal PLoS ONE Section Body Doc Link PMC3017546 Disease Relevance 0.06 Pain Relevance 0.07
The NKp46 immunostaining was stronger in patients with an IL-18 over-expression and a low TWEAK expression, when compared with patients with both IL-18 and TWEAK high expressions.
Positive_regulation (over) of Gene_expression (expression) of IL-18
6) Confidence 0.42 Published 2011 Journal PLoS ONE Section Abstract Doc Link PMC3017546 Disease Relevance 0.26 Pain Relevance 0.08
The NKp46 immunostaining was stronger in patients with IL-18 over-expression and simultaneously a low TWEAK expression (Figure 4A) if compared with patients with IL-18 and TWEAK over-expression (Figure 4B).
Positive_regulation (over) of Gene_expression (expression) of IL-18
7) Confidence 0.42 Published 2011 Journal PLoS ONE Section Body Doc Link PMC3017546 Disease Relevance 0 Pain Relevance 0.18
Effect of IL-12 and IL-18 on PHA/PMA-stimulated PBMCs
Positive_regulation (stimulated) of Gene_expression (Effect) of IL-18
8) Confidence 0.41 Published 2004 Journal Arthritis Res Ther Section Body Doc Link PMC400411 Disease Relevance 0.90 Pain Relevance 0.45
These observations indicate that the stimulation of PHA/PMA induces PBMCs to produce significant amounts of IL-18.
Positive_regulation (induces) of Gene_expression (produce) of IL-18
9) Confidence 0.41 Published 2004 Journal Arthritis Res Ther Section Body Doc Link PMC400411 Disease Relevance 0.83 Pain Relevance 0.39
To investigate further into genetic variants within the IL18 promoter region, we observed in the database [51] a variant in this region that could have a potential role in IL-18 expression (IL18-1297 or rs360719).
Positive_regulation (role) of Gene_expression (expression) of IL18
10) Confidence 0.40 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2888200 Disease Relevance 0.50 Pain Relevance 0.13
Immunohistochemistry for pancreatic IL-18 expression was performed.
Positive_regulation (pancreatic) of Gene_expression (expression) of IL-18
11) Confidence 0.38 Published 2006 Journal World J. Gastroenterol. Section Body Doc Link 17072982 Disease Relevance 0 Pain Relevance 0
Furthermore, IL-18 acts in synergy with IL-12 to promote the development of T helper 1 responses.55 Recently, increased IL-18 expression has been reported in human atherosclerotic plaque, mediating INF-?
Positive_regulation (increased) of Gene_expression (expression) of IL-18 in plaque associated with atherosclerotic plaque
12) Confidence 0.38 Published 2006 Journal Biomark Insights Section Body Doc Link PMC2716777 Disease Relevance 1.04 Pain Relevance 0.31
CONCLUSION: Fetuin-A and IL-18 levels seem to be increased in AS patients regardless of disease activity and treatment type.


Positive_regulation (increased) of Gene_expression (levels) of IL-18
13) Confidence 0.36 Published 2010 Journal Int J Rheum Dis Section Body Doc Link 20374388 Disease Relevance 0.10 Pain Relevance 0
Notably, IL-18 synthesis is increased in SJIA, but not in KD [55], indicating that there are differences in the inflammatory milieu in these (sometimes clinically similar) diseases.
Neg (not) Positive_regulation (increased) of Gene_expression (synthesis) of IL-18 associated with mucocutaneous lymph node syndrome, inflammation and disease
14) Confidence 0.35 Published 2010 Journal Clin Proteomics Section Body Doc Link PMC2970804 Disease Relevance 0.68 Pain Relevance 0.30
Furthermore, IL-18 acts in synergy with IL-12 to promote the development of T helper 1 responses.55 Recently, increased IL-18 expression has been reported in human atherosclerotic plaque, mediating INF-?
Positive_regulation (mediating) of Gene_expression (expression) of IL-18 in plaque associated with atherosclerotic plaque
15) Confidence 0.26 Published 2006 Journal Biomark Insights Section Body Doc Link PMC2716777 Disease Relevance 1.11 Pain Relevance 0.33
Some pro-angiogenic factors (IL18, IL15, MMP10, MMP28) as well as cell adhesion molecules (CEACAM 1, CEACAM 5, CEACAM 6) were also overexpressed.
Positive_regulation (overexpressed) of Gene_expression (overexpressed) of IL18 associated with adhesions
16) Confidence 0.16 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2927995 Disease Relevance 0.37 Pain Relevance 0
Interleukin-18 gene expression is stimulated by proinflammatory cytokines and also by lipopolysaccharides.
Positive_regulation (stimulated) of Gene_expression (expression) of Interleukin-18 gene associated with cytokine
17) Confidence 0.12 Published 2003 Journal Thromb J Section Body Doc Link PMC179880 Disease Relevance 1.93 Pain Relevance 0.31
For instance, obese patients with impaired fasting glucose exhibit elevated concentrations of interleukin (IL)-8 [8], glucose increases monocyte adhesion to human aortic endothelial cells via stimulation of IL-8 [9], and elevated levels of IL-18 and TNF-?
Positive_regulation (elevated) of Gene_expression (levels) of IL-18 in endothelial cells associated with obesity and adhesions
18) Confidence 0.12 Published 2003 Journal Cardiovasc Diabetol Section Body Doc Link PMC212422 Disease Relevance 1.80 Pain Relevance 0.27
For instance, obese patients with impaired fasting glucose exhibit elevated concentrations of interleukin (IL)-8 [8], glucose increases monocyte adhesion to human aortic endothelial cells via stimulation of IL-8 [9], and elevated levels of IL-18 and TNF-?
Positive_regulation (elevated) of Gene_expression (levels) of IL-18 in endothelial cells associated with obesity and adhesions
19) Confidence 0.12 Published 2003 Journal Cardiovasc Diabetol Section Body Doc Link PMC212422 Disease Relevance 1.57 Pain Relevance 0.25
Increased IL-18 expression is detected in islets during advanced stages of insulitis and correlates with elevated transcripts for interferon-?
Positive_regulation (Increased) of Gene_expression (expression) of IL-18
20) Confidence 0.11 Published 2003 Journal Cardiovasc Diabetol Section Body Doc Link PMC212422 Disease Relevance 1.11 Pain Relevance 0.25

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