INT113433

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Context Info
Confidence 0.47
First Reported 2003
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 1.84
Pain Relevance 0.22

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endoplasmic reticulum (UCHL1) intracellular (UCHL1) ligase activity (UCHL1)
response to stress (UCHL1) cytoplasm (UCHL1) cell proliferation (UCHL1)
Anatomy Link Frequency
Neuronal 2
UCHL1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Neuropathic pain 2 96.76 Very High Very High Very High
Dopamine 11 60.80 Quite High
Central nervous system 3 5.00 Very Low Very Low Very Low
midbrain 2 5.00 Very Low Very Low Very Low
Catecholamine 2 5.00 Very Low Very Low Very Low
Glutamate 2 5.00 Very Low Very Low Very Low
Locus ceruleus 1 5.00 Very Low Very Low Very Low
gABA 1 5.00 Very Low Very Low Very Low
monoamine 1 5.00 Very Low Very Low Very Low
Substantia nigra 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Neurodegenerative Disease 4 99.44 Very High Very High Very High
Disease 90 99.36 Very High Very High Very High
Cancer 7 97.24 Very High Very High Very High
Neuropathic Pain 2 96.76 Very High Very High Very High
Lung Cancer 8 91.44 High High
Death 14 72.24 Quite High
Toxicity 7 44.76 Quite Low
Parkinson's Disease 49 20.48 Low Low
Stress 17 5.00 Very Low Very Low Very Low
Apoptosis 7 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Mutations of the gene UCHL1 (PARK5) and alteration of coded protein activity have been found to associate with several neurodegenerative disorders.
PARK5 Binding (associate) of associated with neurodegenerative disease
1) Confidence 0.47 Published 2010 Journal Frontiers in Aging Neuroscience Section Body Doc Link PMC2890153 Disease Relevance 0.76 Pain Relevance 0.03
Neuronal ubiquitin C-terminal hydrolase (UCH-L1) has been linked to Parkinson's disease (PD), the progression of certain nonneuronal tumors, and neuropathic pain.
UCH-L1 Binding (linked) of in Neuronal associated with cancer, neuropathic pain and disease
2) Confidence 0.43 Published 2003 Journal Chem. Biol. Section Abstract Doc Link 14522054 Disease Relevance 0.54 Pain Relevance 0.10
Neuronal ubiquitin C-terminal hydrolase (UCH-L1) has been linked to Parkinson's disease (PD), the progression of certain nonneuronal tumors, and neuropathic pain.
C-terminal hydrolase Binding (linked) of in Neuronal associated with cancer, neuropathic pain and disease
3) Confidence 0.38 Published 2003 Journal Chem. Biol. Section Abstract Doc Link 14522054 Disease Relevance 0.54 Pain Relevance 0.10

General Comments

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