INT113434

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Context Info
Confidence 0.53
First Reported 2003
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 1.34
Pain Relevance 0.12

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endoplasmic reticulum (UCHL1) intracellular (UCHL1) ligase activity (UCHL1)
response to stress (UCHL1) cytoplasm (UCHL1) cell proliferation (UCHL1)
Anatomy Link Frequency
corpuscles 2
UCHL1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Neuropathic pain 2 61.20 Quite High
chemokine 2 34.24 Quite Low
Inflammation 4 5.00 Very Low Very Low Very Low
Nerve growth factor 3 5.00 Very Low Very Low Very Low
imagery 3 5.00 Very Low Very Low Very Low
Peripheral nervous system 1 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
Neuropeptide 1 5.00 Very Low Very Low Very Low
addiction 1 5.00 Very Low Very Low Very Low
agonist 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Lung Cancer 8 98.56 Very High Very High Very High
Cancer 6 92.44 High High
Neuropathic Pain 2 61.20 Quite High
Disease 3 58.24 Quite High
Asthma 22 5.00 Very Low Very Low Very Low
INFLAMMATION 4 5.00 Very Low Very Low Very Low
Rhinitis 4 5.00 Very Low Very Low Very Low
Adhesions 3 5.00 Very Low Very Low Very Low
Pulmonary Disease 3 5.00 Very Low Very Low Very Low
Nicotine Addiction 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Inhibition of UCH-L1 expression in the H1299 cell line using RNAi had a similar proproliferative effect, suggesting that the UCH-L1 enzymatic activity is antiproliferative and that UCH-L1 expression may be a response to tumor growth.
Negative_regulation (Inhibition) of Gene_expression (expression) of UCH-L1 associated with cancer
1) Confidence 0.53 Published 2003 Journal Chem. Biol. Section Abstract Doc Link 14522054 Disease Relevance 0.67 Pain Relevance 0.06
Inhibition of UCH-L1 expression in the H1299 cell line using RNAi had a similar proproliferative effect, suggesting that the UCH-L1 enzymatic activity is antiproliferative and that UCH-L1 expression may be a response to tumor growth.
Negative_regulation (Inhibition) of Gene_expression (expression) of UCH-L1 associated with cancer
2) Confidence 0.38 Published 2003 Journal Chem. Biol. Section Abstract Doc Link 14522054 Disease Relevance 0.67 Pain Relevance 0.06
Specifically, the relative area of PGP 9.5 positive and MBP positive was 7.0 ± 3.0 percent compared to PGP 9.5 negative and MBP positive 5.9 ± 1.3 percent, (P > .7, n = 3 determinations from 10 distinct patients).
Negative_regulation (positive) of Gene_expression (positive) of PGP 9.5
3) Confidence 0.14 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2843899 Disease Relevance 0 Pain Relevance 0
The axons of the corpuscles, including those within the small corpuscular structures, exhibited marked PGP 9.5 immunoreaction.
Negative_regulation (exhibited) of Gene_expression (immunoreaction) of PGP 9.5 in corpuscles
4) Confidence 0.05 Published 2006 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1569833 Disease Relevance 0 Pain Relevance 0

General Comments

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