INT113438

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Context Info
Confidence 0.11
First Reported 2003
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 5
Disease Relevance 3.26
Pain Relevance 2.29

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
plasma 1
liver 1
brain 1
GPM6A (Homo sapiens)
Pain Link Frequency Relevance Heat
Morphine 126 99.80 Very High Very High Very High
fibrosis 30 99.50 Very High Very High Very High
Analgesic 3 99.28 Very High Very High Very High
Opioid 7 96.12 Very High Very High Very High
analgesia 1 94.44 High High
cytokine 3 81.36 Quite High
allodynia 1 75.44 Quite High
Bioavailability 1 75.00 Quite High
Pain 6 59.76 Quite High
Inflammation 7 58.72 Quite High
Disease Link Frequency Relevance Heat
Cirrhosis 330 99.84 Very High Very High Very High
Fibrosis 24 99.56 Very High Very High Very High
Vomiting 6 98.16 Very High Very High Very High
Sleep Disorders 3 97.76 Very High Very High Very High
Delirium 1 77.28 Quite High
Myoclonus 1 76.48 Quite High
Neuropathic Pain 1 75.44 Quite High
Nociception 1 70.56 Quite High
Disease 23 67.40 Quite High
Pain 8 59.76 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Due to first pass metabolism and slow accumulation of M6G in the brain the analgesic activity of M6G is most prominent during oral long-term treatment with morphine while single dose studies show less contribution from M6G to the analgesic effects from morphine [2,3,6].
Positive_regulation (accumulation) of M6G in brain associated with analgesic and morphine
1) Confidence 0.11 Published 2004 Journal BMC Clin Pharmacol Section Body Doc Link PMC526195 Disease Relevance 0.56 Pain Relevance 1.34
Previously, we reported an hepatic accumulation of M6PHSA and pPBHSA of 59 and 48% of the administered dose, 10 min after iv injection (4,5).
Positive_regulation (accumulation) of M6PHSA
2) Confidence 0.01 Published 2007 Journal Pharm Res Section Body Doc Link PMC1915609 Disease Relevance 0.68 Pain Relevance 0.03
The expression of these M6P/IGFII receptors increases as a result of HSC activation during liver fibrosis (11) enabling selective accumulation of M6PHSA in HSC of fibrotic rats (4).
Positive_regulation (accumulation) of M6PHSA in liver associated with fibrosis and cirrhosis
3) Confidence 0.01 Published 2007 Journal Pharm Res Section Body Doc Link PMC1915609 Disease Relevance 1.17 Pain Relevance 0.09
However, inhibition by polyinosinic acid, as found in our studies, suggests that not scavenger receptor class B, but rather class A contributed to the accumulation of M6PHSA conjugates in the HSC.
Positive_regulation (accumulation) of M6PHSA associated with cirrhosis
4) Confidence 0.01 Published 2007 Journal Pharm Res Section Body Doc Link PMC1915609 Disease Relevance 0.80 Pain Relevance 0
In SOP, but not ROP, rabbits, the plasma concentrations of morphine, M3G and M6G were significantly increased compared with those in normal rabbits.
Positive_regulation (increased) of M6G in plasma associated with morphine
5) Confidence 0.00 Published 2003 Journal Int J Pharm Section Abstract Doc Link 14522119 Disease Relevance 0.06 Pain Relevance 0.83

General Comments

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