INT113439

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Context Info
Confidence 0.11
First Reported 2003
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 0.84
Pain Relevance 2.01

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (OPN1LW) plasma membrane (OPN1LW) signal transducer activity (OPN1LW)
Anatomy Link Frequency
plasma 1
OPN1LW (Homo sapiens)
Pain Link Frequency Relevance Heat
Morphine 10 100.00 Very High Very High Very High
carbamazepine 213 99.74 Very High Very High Very High
Pain 101 91.68 High High
Gabapentin 16 89.52 High High
Bioavailability 1 75.00 Quite High
Inflammation 2 58.72 Quite High
Analgesic 14 50.00 Quite Low
Pain score 1 39.76 Quite Low
Paroxysmal pain 3 33.52 Quite Low
Breakthrough pain 1 7.48 Low Low
Disease Link Frequency Relevance Heat
Pain 107 91.68 High High
INFLAMMATION 2 58.72 Quite High
Neuralgia 45 5.00 Very Low Very Low Very Low
Demyelinating Disease 6 5.00 Very Low Very Low Very Low
Hypersensitivity 4 5.00 Very Low Very Low Very Low
Cancer 3 5.00 Very Low Very Low Very Low
Depression 2 5.00 Very Low Very Low Very Low
Ganglion Cysts 2 5.00 Very Low Very Low Very Low
Neuropathic Pain 2 5.00 Very Low Very Low Very Low
Hypertension 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
However, the clinical insecurity of a ROPonly protocol21 resulted, in the present study, in the evaluation of only two protocols, which allowed a study blinded also to the patients: CBZ monotherapy (with injection of saline) and CBZ + ROP (with injection of ROP).


Positive_regulation (injection) of ROP associated with carbamazepine
1) Confidence 0.11 Published 2010 Journal Journal of pain research Section Body Doc Link PMC3004633 Disease Relevance 0.78 Pain Relevance 1.17
In SOP, but not ROP, rabbits, the plasma concentrations of morphine, M3G and M6G were significantly increased compared with those in normal rabbits.
Positive_regulation (increased) of ROP in plasma associated with morphine
2) Confidence 0.01 Published 2003 Journal Int J Pharm Section Abstract Doc Link 14522119 Disease Relevance 0.06 Pain Relevance 0.84

General Comments

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