INT113450

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Context Info
Confidence 0.21
First Reported 2003
Last Reported 2006
Negated 0
Speculated 0
Reported most in Abstract
Documents 4
Total Number 4
Disease Relevance 1.81
Pain Relevance 2.73

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (ASIC3) transport (ASIC3) plasma membrane (ASIC3)
cytoplasm (ASIC3)
Anatomy Link Frequency
sensory neurons 3
ASIC3 (Homo sapiens)
Pain Link Frequency Relevance Heat
sodium channel 2 100.00 Very High Very High Very High
Neuropeptide 2 99.92 Very High Very High Very High
tissue acidosis 2 99.24 Very High Very High Very High
Hyperalgesia 4 96.08 Very High Very High Very High
IPN 4 95.08 Very High Very High Very High
Nerve growth factor 18 93.52 High High
Pain 3 91.20 High High
Inflammation 10 89.68 High High
dorsal root ganglion 2 88.24 High High
Kinase C 8 85.52 High High
Disease Link Frequency Relevance Heat
Acidosis 2 98.96 Very High Very High Very High
Hyperalgesia 4 96.08 Very High Very High Very High
Inflammatory Pain 4 95.08 Very High Very High Very High
Pain 3 91.20 High High
INFLAMMATION 8 89.68 High High
Ganglion Cysts 3 88.24 High High
Nociception 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Acid-sensing ion channel 3 (ASIC3), a depolarizing sodium channel gated by protons during tissue acidosis, is specifically expressed in sensory neurons.
Regulation (gated) of Acid-sensing ion channel 3 in sensory neurons associated with acidosis, sodium channel and tissue acidosis
1) Confidence 0.21 Published 2003 Journal J. Biol. Chem. Section Abstract Doc Link 14522957 Disease Relevance 0.65 Pain Relevance 0.90
Acid-sensing ion channel 3 (ASIC3), a depolarizing sodium channel gated by protons during tissue acidosis, is specifically expressed in sensory neurons.
Regulation (gated) of ASIC3 in sensory neurons associated with acidosis, sodium channel and tissue acidosis
2) Confidence 0.21 Published 2003 Journal J. Biol. Chem. Section Abstract Doc Link 14522957 Disease Relevance 0.65 Pain Relevance 0.90
In the presence of NHERF-1, the ASIC3 subcellular localization is modified, and the channel co-localizes with ezrin, a member of the ezrin-radixin-moesin family of actin-binding proteins, providing the first direct link between ASIC3 and the cortical cytoskeleton.
Regulation (modified) of ASIC3
3) Confidence 0.21 Published 2006 Journal J. Biol. Chem. Section Abstract Doc Link 16234233 Disease Relevance 0.24 Pain Relevance 0.42
ASIC2b-dependent regulation of ASIC3, an essential acid-sensing ion channel subunit in sensory neurons via the partner protein PICK-1.
Regulation (regulation) of ASIC3 in sensory neurons
4) Confidence 0.13 Published 2004 Journal J. Biol. Chem. Section Title Doc Link 14976185 Disease Relevance 0.26 Pain Relevance 0.51

General Comments

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