INT113451

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Context Info
Confidence 0.07
First Reported 2003
Last Reported 2003
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 2
Disease Relevance 1.35
Pain Relevance 2.18

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Ngf, ASIC3) transport (ASIC3) aging (Ngf)
cytoplasm (ASIC3) extracellular space (Ngf) extracellular region (Ngf)
Ngf (Rattus norvegicus)
ASIC3 (Homo sapiens)
Pain Link Frequency Relevance Heat
Nerve growth factor 18 100.00 Very High Very High Very High
Inflammation 10 100.00 Very High Very High Very High
Kinase C 2 100.00 Very High Very High Very High
Hyperalgesia 4 95.64 Very High Very High Very High
hyperexcitability 2 94.48 High High
tissue acidosis 2 81.72 Quite High
sodium channel 2 80.12 Quite High
Neuropeptide 2 77.44 Quite High
IPN 4 75.84 Quite High
Disease Link Frequency Relevance Heat
INFLAMMATION 8 100.00 Very High Very High Very High
Hyperalgesia 4 95.64 Very High Very High Very High
Acidosis 2 81.72 Quite High
Inflammatory Pain 4 72.60 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
NGF controls ASIC3 basal expression through constitutive activation of a trkA/phospholipase C/protein kinase C pathway, (ii). high inflammatory-like NGF induces ASIC3 overexpression through a trkA/JNK/p38MAPK pathway and a p75-dependent mechanism as a transcriptional switch, and (iii).
NGF Regulation (controls) of Gene_expression (expression) of ASIC3 associated with kinase c, inflammation and nerve growth factor
1) Confidence 0.07 Published 2003 Journal J. Biol. Chem. Section Abstract Doc Link 14522957 Disease Relevance 0.67 Pain Relevance 1.10
NGF controls ASIC3 basal expression through constitutive activation of a trkA/phospholipase C/protein kinase C pathway, (ii). high inflammatory-like NGF induces ASIC3 overexpression through a trkA/JNK/p38MAPK pathway and a p75-dependent mechanism as a transcriptional switch, and (iii).
NGF Regulation (controls) of Gene_expression (expression) of ASIC3 associated with kinase c, inflammation and nerve growth factor
2) Confidence 0.07 Published 2003 Journal J. Biol. Chem. Section Abstract Doc Link 14522957 Disease Relevance 0.67 Pain Relevance 1.08

General Comments

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