INT113452

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Context Info
Confidence 0.19
First Reported 2003
Last Reported 2003
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 2
Disease Relevance 1.34
Pain Relevance 2.08

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Ngf, ASIC3) transport (ASIC3) aging (Ngf)
cytoplasm (ASIC3) extracellular space (Ngf) extracellular region (Ngf)
Anatomy Link Frequency
neuron 2
Ngf (Rattus norvegicus)
ASIC3 (Homo sapiens)
Pain Link Frequency Relevance Heat
Nerve growth factor 18 100.00 Very High Very High Very High
Inflammation 10 99.88 Very High Very High Very High
Kinase C 2 99.22 Very High Very High Very High
hyperexcitability 2 96.00 Very High Very High Very High
Hyperalgesia 4 94.64 High High
tissue acidosis 2 93.76 High High
sodium channel 2 92.16 High High
Neuropeptide 2 89.48 High High
IPN 4 84.64 Quite High
Disease Link Frequency Relevance Heat
INFLAMMATION 8 99.88 Very High Very High Very High
Hyperalgesia 4 94.64 High High
Acidosis 2 93.76 High High
Inflammatory Pain 4 84.64 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We previously showed that low endogenous NGF was responsible for ASIC3 basal expression and high NGF during inflammation increased ASIC3 expression parallely to the development of neuron hyperexcitability associated with hyperalgesia.
NGF Positive_regulation (responsible) of Gene_expression (expression) of ASIC3 in neuron associated with hyperalgesia, inflammation, nerve growth factor and hyperexcitability
1) Confidence 0.19 Published 2003 Journal J. Biol. Chem. Section Abstract Doc Link 14522957 Disease Relevance 0.70 Pain Relevance 1.02
NGF controls ASIC3 basal expression through constitutive activation of a trkA/phospholipase C/protein kinase C pathway, (ii). high inflammatory-like NGF induces ASIC3 overexpression through a trkA/JNK/p38MAPK pathway and a p75-dependent mechanism as a transcriptional switch, and (iii).
NGF Positive_regulation (induces) of Gene_expression (overexpression) of ASIC3 associated with kinase c, inflammation and nerve growth factor
2) Confidence 0.13 Published 2003 Journal J. Biol. Chem. Section Abstract Doc Link 14522957 Disease Relevance 0.64 Pain Relevance 1.05

General Comments

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