INT11346

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.41
First Reported 1990
Last Reported 2011
Negated 3
Speculated 0
Reported most in Body
Documents 39
Total Number 39
Disease Relevance 24.88
Pain Relevance 21.21

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Mtx1)
Anatomy Link Frequency
liver 2
bone marrow 2
joint 1
hematopoietic stem cell 1
urine 1
Mtx1 (Mus musculus)
Pain Link Frequency Relevance Heat
methotrexate 1888 100.00 Very High Very High Very High
cINOD 125 100.00 Very High Very High Very High
metalloproteinase 58 100.00 Very High Very High Very High
COX-2 inhibitor 4 99.80 Very High Very High Very High
Infliximab 195 99.76 Very High Very High Very High
rheumatoid arthritis 553 99.66 Very High Very High Very High
Etanercept 371 98.48 Very High Very High Very High
adenocard 40 96.80 Very High Very High Very High
Arthritis 695 96.32 Very High Very High Very High
Osteoarthritis 86 96.16 Very High Very High Very High
Disease Link Frequency Relevance Heat
Toxicity 131 100.00 Very High Very High Very High
Opportunistic Infections 2 99.92 Very High Very High Very High
Rheumatoid Arthritis 770 99.66 Very High Very High Very High
Thrombocytopenia 17 99.42 Very High Very High Very High
Cancer 52 99.40 Very High Very High Very High
INFLAMMATION 142 99.04 Very High Very High Very High
Weight Loss 1 98.96 Very High Very High Very High
Infection 82 98.80 Very High Very High Very High
Hepatotoxicity 22 98.28 Very High Very High Very High
Osteogenic Sarcomas 4 98.08 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
MTX has been associated with elevated transaminases and potential hepatotoxicity.
MTX Binding (associated) of associated with hepatotoxicity and methotrexate
1) Confidence 0.41 Published 2010 Journal Pediatr Rheumatol Online J Section Body Doc Link PMC2949753 Disease Relevance 1.85 Pain Relevance 0.39
Dupuis et al. [25] evaluated the effects of NSAIDs with recognized MTX interactions.
MTX Binding (recognized) of associated with cinod and methotrexate
2) Confidence 0.41 Published 2008 Journal Mod Rheumatol Section Body Doc Link PMC2638602 Disease Relevance 0.47 Pain Relevance 1.43
Dupuis et al. [25] evaluated the effects of NSAIDs with recognized MTX interactions.
MTX Binding (interactions) of associated with cinod and methotrexate
3) Confidence 0.41 Published 2008 Journal Mod Rheumatol Section Body Doc Link PMC2638602 Disease Relevance 0.47 Pain Relevance 1.43
A direct association of MTX with this event can not be ruled out.
MTX Binding (association) of associated with methotrexate
4) Confidence 0.41 Published 2008 Journal Mod Rheumatol Section Body Doc Link PMC2638602 Disease Relevance 1.46 Pain Relevance 0.71
Specifically, associations were observed between several ADORA2a SNPs and GI AEs on MTX.
MTX Binding (associations) of associated with methotrexate
5) Confidence 0.32 Published 2008 Journal Rheumatology (Oxford, England) Section Body Doc Link PMC2468887 Disease Relevance 0.25 Pain Relevance 0.22
In the UK, approval of MTX preparation has not been issued directly, but the guidelines for etanercept using biological preparations (the most powerful means of treatment currently available) state that these preparations are used in cases failing to respond to MTX, without limiting the subjects of MTX treatment to those with multiple-type joint disease.
MTX Binding (respond) of in joint associated with arthropathy, etanercept and methotrexate
6) Confidence 0.31 Published 2008 Journal Mod Rheumatol Section Body Doc Link PMC2638602 Disease Relevance 0.78 Pain Relevance 0.62
Double-blind randomized studies comparing MTX with other drugs
MTX Binding (comparing) of associated with methotrexate
7) Confidence 0.31 Published 2008 Journal Mod Rheumatol Section Body Doc Link PMC2638602 Disease Relevance 1.31 Pain Relevance 0.88
Some cases reported in the literature underline the potential toxicity of the association of low dose MTX with an NSAID, but most of the pharmacological studies do not confirm this hypothesis.
MTX Binding (association) of associated with toxicity, cinod and methotrexate
8) Confidence 0.31 Published 1997 Journal Therapie Section Abstract Doc Link 9231508 Disease Relevance 0.52 Pain Relevance 0.96
Six previously published case reports and five pharmacokinetic studies regarding MTX and NSAID interactions are available to assist in the evaluation of this potential interaction.
MTX Binding (interactions) of
9) Confidence 0.31 Published 1992 Journal Ann Pharmacother Section Body Doc Link 1554938 Disease Relevance 0 Pain Relevance 0
This procedure has avoided the reoccurrence of thrombocytopenia and controlled further drug interactions of NSAIDs and MTX in our patients.
MTX Binding (interactions) of associated with cinod, thrombocytopenia and methotrexate
10) Confidence 0.31 Published 1996 Journal Clin. Rheumatol. Section Abstract Doc Link 8777850 Disease Relevance 0.72 Pain Relevance 1.03
Current data, in the form of small studies or case reports, show that MTX's hepatic toxicity is not yet fully defined, that its acute pulmonary toxicity is significant, that systemic fungal infections may be associated with MTX use in rheumatoid arthritis (RA), that unexplained significant weight loss can be a problem, and that the consequence of drug interactions with MTX are not yet fully known.
MTX Binding (interactions) of associated with fungal infection, toxicity, weight loss, rheumatoid arthritis and methotrexate
11) Confidence 0.31 Published 1990 Journal Semin. Arthritis Rheum. Section Abstract Doc Link 2251507 Disease Relevance 1.02 Pain Relevance 0.77
There was no observable interaction between MTX and either ibuprofen or flurbiprofen, with respect to the area under the curve per unit dose, Cmax, Cmax/dose, Tmax, and serum half-life.
MTX Neg (no) Binding (interaction) of associated with methotrexate
12) Confidence 0.31 Published 1990 Journal J. Rheumatol. Section Abstract Doc Link 2213774 Disease Relevance 0.23 Pain Relevance 0.64
This procedure has prevented the reoccurrence of thrombocytopenia and controlled further drug interactions of NSAIDs and MTX in our patients.
MTX Binding (interactions) of associated with cinod, thrombocytopenia and methotrexate
13) Confidence 0.31 Published 1996 Journal Clin. Rheumatol. Section Abstract Doc Link 8793258 Disease Relevance 0.71 Pain Relevance 1.03
Precautions must be taken to ensure a high urine flow and an alkaline urine pH, so as to prevent precipitation of MTX in urine.
MTX Binding (precipitation) of in urine associated with methotrexate
14) Confidence 0.31 Published 1996 Journal Clin. Chem. Section Abstract Doc Link 8697606 Disease Relevance 0.70 Pain Relevance 0.38
The clinical pharmacology and clinically important drug interactions of methotrexate (MTX) are reviewed.
MTX Binding (interactions) of associated with methotrexate
15) Confidence 0.30 Published 1995 Journal Br. J. Rheumatol. Section Abstract Doc Link 8535644 Disease Relevance 0.07 Pain Relevance 0.47
In agreement with Dolezalova and colleagues, we did not find a strong association of MTXglun concentrations (total or long chain) with MTX response (unpublished data), but we are actively investigating associations with clinical outcomes such as GI toxicity and hepatic enzyme elevation.
MTX Neg (not) Binding (association) of associated with toxicity and methotrexate
16) Confidence 0.26 Published 2010 Journal Human Genomics and Proteomics : HGP Section Body Doc Link PMC2958653 Disease Relevance 0.10 Pain Relevance 0.32
Additionally, 5-methyltetrahydrofolate homocysteine methyltransferase (MTR) 2756GG was found to be overrepresented in pediatric osteosarcoma patients suffering GI toxicity after being treated with high dose MTX [49], and it has been associated with toxicity with low dose MTX in an adult RA cohort [50], supporting the potential for a similar effect in children with JIA.
MTX Binding (associated) of associated with toxicity, rheumatoid arthritis, osteogenic sarcomas, methotrexate and arthritis
17) Confidence 0.25 Published 2010 Journal Human Genomics and Proteomics : HGP Section Body Doc Link PMC2958653 Disease Relevance 0.91 Pain Relevance 0.43
Alternatively, upregulation of the efflux transporter ABCG2 protein expression has been associated with MTX resistance in cancer cells [45], but no associations with SNPs evaluated in FPGS and clinical effects of MTX have been observed [44].
MTX Binding (associated) of associated with cancer and methotrexate
18) Confidence 0.25 Published 2010 Journal Human Genomics and Proteomics : HGP Section Body Doc Link PMC2958653 Disease Relevance 0.34 Pain Relevance 0.27
These changes are not found with nonsteroidal anti-inflammatory drug therapy, the drugs most commonly found in association with MTX.
MTX Binding (association) of associated with inflammation, cinod and methotrexate
19) Confidence 0.20 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2945037 Disease Relevance 1.15 Pain Relevance 0.80
However, we have not identified previous reports suggesting interaction between MTX and COX-2 inhibitors.
MTX Binding (interaction) of associated with cox-2 inhibitor and methotrexate
20) Confidence 0.20 Published 2002 Journal Del Med J Section Abstract Doc Link 15595320 Disease Relevance 1.82 Pain Relevance 0.80

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox