INT113472

Context Info Confidence 0.47 First Reported 2003 Last Reported 2003 Negated 1 Speculated 0 Reported most in Abstract Documents 1 Total Number 2 Disease Relevance 0.45 Pain Relevance 0.75

signal transduction (TNF) extracellular space (TNF) extracellular region (TNF) plasma membrane (TNF) intracellular (TNF) extracellular matrix organization (TNF)

TNF (Homo sapiens) MMP14 (Homo sapiens)

Pain Link Frequency Relevance Heat cytokine 8 91.40 Inflammation 6 87.44 metalloproteinase 4 75.00 Chronic pancreatitis 2 73.52

Disease Link Frequency Relevance Heat INFLAMMATION 6 87.44 Pancreatitis 2 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

IL-1l and TNF-alpha stimulated the MMP-1 secretion in a dose- and time-dependent manner.

TNF-alpha Positive_regulation (stimulated) of Localization (secretion) of MMP-1

1) Confidence 0.47 Published 2003 Journal Pancreatology Section Abstract Doc Link 14526152 Disease Relevance 0.22 Pain Relevance 0.34

In contrast, SB203580 (p38 MAPK inhibitor), GF109203X (PKC inhibitor), and PDTC (NF-kappaB inhibitor) did not alter the MMP-1 secretion induced by IL-1beta and TNF-alpha.

TNF-alpha Neg (not) Positive_regulation (induced) of Localization (secretion) of MMP-1

2) Confidence 0.47 Published 2003 Journal Pancreatology Section Abstract Doc Link 14526152 Disease Relevance 0.23 Pain Relevance 0.41

General Comments

This test has worked.