INT113479

Context Info Confidence 0.51 First Reported 2003 Last Reported 2011 Negated 0 Speculated 0 Reported most in Body Documents 3 Total Number 4 Disease Relevance 1.81 Pain Relevance 1.70

cytoplasm (MMP14)

Anatomy Link Frequency colon 1 MMP14 (Homo sapiens)

Pain Link Frequency Relevance Heat metalloproteinase 168 100.00 COX-2 inhibitor 19 96.16 cytokine 9 94.12 Inflammation 33 89.20 chemokine 6 73.96 cINOD 1 73.44 aspirin 1 72.80 Chronic pancreatitis 1 36.72 rheumatoid arthritis 14 5.00 Multiple sclerosis 8 5.00

Disease Link Frequency Relevance Heat Colon Cancer 12 99.56 Prostate Cancer 5 96.92 Cancer 103 91.92 Lung Cancer 5 91.60 INFLAMMATION 33 89.20 Breast Cancer 68 82.44 Advanced Or Metastatic Breast Cancer 2 66.24 Disease 20 56.12 Metastasis 30 39.44 Malignant Neoplastic Disease 5 30.24

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

MMP-1 mRNA expression was evaluated by Northern blotting.

Transcription (expression) of MMP-1

1) Confidence 0.51 Published 2003 Journal Pancreatology Section Abstract Doc Link 14526152 Disease Relevance 0.21 Pain Relevance 0.31

MMP-14 and -15 mRNA transcripts are expressed in a number of tissues but are distributed quite differently.

Transcription (transcripts) of MMP-14

2) Confidence 0.36 Published 2011 Journal Biochemistry Research International Section Body Doc Link PMC2989751 Disease Relevance 0.34 Pain Relevance 0.42

MMP-14 and -15 mRNA transcripts are expressed in a number of tissues but are distributed quite differently.

Transcription (expressed) of MMP-14

3) Confidence 0.27 Published 2011 Journal Biochemistry Research International Section Body Doc Link PMC2989751 Disease Relevance 0.35 Pain Relevance 0.42

Tsuji et al. [16] observed an increase in MMP-2 activation and increase in MMP-14 mRNA expression by Caco-2 colon cancer cells, which showed high levels of COX-2.

Transcription (expression) of MMP-14 in colon associated with colon cancer and metalloproteinase

4) Confidence 0.07 Published 2006 Journal BMC Cancer Section Body Doc Link PMC1559713 Disease Relevance 0.90 Pain Relevance 0.54

General Comments

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