INT113485

Context Info Confidence 0.77 First Reported 2003 Last Reported 2010 Negated 2 Speculated 1 Reported most in Abstract Documents 11 Total Number 12 Disease Relevance 3.44 Pain Relevance 4.19

cytoplasm (MMP14)

MMP14 (Homo sapiens)

Pain Link Frequency Relevance Heat metalloproteinase 30 100.00 Chronic pancreatitis 11 99.90 cytokine 44 99.82 Inflammation 33 99.64 palliative 43 96.48

Disease Link Frequency Relevance Heat Pancreatitis 11 99.90 INFLAMMATION 33 99.64 Cancer 36 98.52 Hepatocellular Cancer 58 94.48 Metastasis 24 86.08 Lifespan 8 82.88 Residual Neoplasm 3 7.24 Anaemia 1 5.00 Body Weight 1 5.00 Death 1 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Ninety percent of MMP-1 was secreted as inactive form (pro-MMP-1).

Neg (inactive) Localization (secreted) of MMP-1

1) Confidence 0.77 Published 2003 Journal Pancreatology Section Abstract Doc Link 14526152 Disease Relevance 0.22 Pain Relevance 0.34

In conclusion, in human pancreatic periacinar myofibroblasts, MMP-1 secretion was regulated by the pro-inflammatory cytokines via the MEK/ERK cascade.

Localization (secretion) of MMP-1 associated with inflammation and cytokine

2) Confidence 0.77 Published 2003 Journal Pancreatology Section Abstract Doc Link 14526152 Disease Relevance 0.24 Pain Relevance 0.42

Pro-inflammatory cytokine-induced matrix metalloproteinase-1 (MMP-1) secretion in human pancreatic periacinar myofibroblasts.

Localization (secretion) of matrix metalloproteinase-1 associated with inflammation, metalloproteinase and cytokine

3) Confidence 0.77 Published 2003 Journal Pancreatology Section Title Doc Link 14526152 Disease Relevance 0.18 Pain Relevance 0.32

In the present study, we investigated MMP-1 secretion from human pancreatic periacinar myofibroblasts in response to pro-inflammatory cytokines IL-1beta and TNF-alpha.

Spec (investigated) Localization (secretion) of MMP-1 associated with inflammation and cytokine

4) Confidence 0.77 Published 2003 Journal Pancreatology Section Abstract Doc Link 14526152 Disease Relevance 0.17 Pain Relevance 0.30

Pro-inflammatory cytokine-induced matrix metalloproteinase-1 (MMP-1) secretion in human pancreatic periacinar myofibroblasts.

Localization (secretion) of MMP-1 associated with inflammation, metalloproteinase and cytokine

5) Confidence 0.77 Published 2003 Journal Pancreatology Section Title Doc Link 14526152 Disease Relevance 0.18 Pain Relevance 0.32

IL-1l and TNF-alpha stimulated the MMP-1 secretion in a dose- and time-dependent manner.

Localization (secretion) of MMP-1

6) Confidence 0.77 Published 2003 Journal Pancreatology Section Abstract Doc Link 14526152 Disease Relevance 0.22 Pain Relevance 0.34

In contrast, SB203580 (p38 MAPK inhibitor), GF109203X (PKC inhibitor), and PDTC (NF-kappaB inhibitor) did not alter the MMP-1 secretion induced by IL-1beta and TNF-alpha.

Localization (secretion) of MMP-1

7) Confidence 0.77 Published 2003 Journal Pancreatology Section Abstract Doc Link 14526152 Disease Relevance 0.23 Pain Relevance 0.41

MMP-1 secretion was measured by an enzyme-linked immunosorbent assay.

Localization (secretion) of MMP-1

8) Confidence 0.77 Published 2003 Journal Pancreatology Section Abstract Doc Link 14526152 Disease Relevance 0.17 Pain Relevance 0.30

The alteration of endostatin (a potent angiogenesis inhibitor) and MT1-MMP (an activator of MMP2) was minor, which indicated that elevated tumor VEGF and increased MMP2 activity were not directly due to endostatin and MT1-MMP, whose detailed molecular mechanism remains to be elucidated.

Localization (mechanism) of MT1-MMP associated with cancer

9) Confidence 0.73 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2976755 Disease Relevance 1.10 Pain Relevance 0.36

Thus, human pancreatic periacinar myofibroblasts may play an important role in the remodeling of damaged pancreatic tissue in chronic pancreatitis via MMP-1 secretion.

Localization (secretion) of MMP-1 associated with chronic pancreatitis

10) Confidence 0.67 Published 2003 Journal Pancreatology Section Abstract Doc Link 14526152 Disease Relevance 0.32 Pain Relevance 0.39

We also attempted to clarify the intracellular signaling pathways mediating the cytokine-induced MMP-1 secretion.

Localization (secretion) of MMP-1 associated with cytokine

11) Confidence 0.67 Published 2003 Journal Pancreatology Section Abstract Doc Link 14526152 Disease Relevance 0.17 Pain Relevance 0.30

Ninety percent of MMP-1 was secreted as inactive form (pro-MMP-1).

Neg (inactive) Localization (secreted) of MMP-1

12) Confidence 0.59 Published 2003 Journal Pancreatology Section Abstract Doc Link 14526152 Disease Relevance 0.22 Pain Relevance 0.39

General Comments

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