INT113490

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Context Info
Confidence 0.77
First Reported 2003
Last Reported 2010
Negated 0
Speculated 1
Reported most in Abstract
Documents 22
Total Number 23
Disease Relevance 5.45
Pain Relevance 12.27

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transmembrane transport (SCN9A)
Anatomy Link Frequency
aorta 2
neuroendocrine cells 2
ganglia 2
sperm 2
bone marrow 1
SCN9A (Homo sapiens)
Pain Link Frequency Relevance Heat
tetrodotoxin 99 100.00 Very High Very High Very High
sodium channel 79 100.00 Very High Very High Very High
Nav1.7 25 100.00 Very High Very High Very High
nav1.8 19 100.00 Very High Very High Very High
Nav1.9 8 100.00 Very High Very High Very High
potassium channel 12 99.88 Very High Very High Very High
Neuropeptide 14 99.86 Very High Very High Very High
Nav1.6 14 99.78 Very High Very High Very High
Peripheral nervous system 6 99.68 Very High Very High Very High
Neuropathic pain 11 99.54 Very High Very High Very High
Disease Link Frequency Relevance Heat
Nociception 20 99.84 Very High Very High Very High
Neuropathic Pain 16 99.54 Very High Very High Very High
INFLAMMATION 17 99.12 Very High Very High Very High
Injury 13 98.04 Very High Very High Very High
Reprotox - General 1 6 96.52 Very High Very High Very High
Hyperalgesia 3 95.76 Very High Very High Very High
Pain 216 94.80 High High
Ataxia 1 90.40 High High
Frailty 1 89.96 High High
Hyperplasia 4 89.92 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These results suggest that stable transfectants expressing the human PN1 and PN3 sodium channels will be useful tools to define subtype selectivity for sodium channel blockers.
Gene_expression (expressing) of PN1 associated with sodium channel
1) Confidence 0.77 Published 2003 Journal Recept. Channels Section Abstract Doc Link 14527872 Disease Relevance 0.17 Pain Relevance 0.94
Stable expression and characterization of human PN1 and PN3 sodium channels.
Gene_expression (expression) of PN1 associated with neuropeptide and sodium channel
2) Confidence 0.77 Published 2003 Journal Recept. Channels Section Title Doc Link 14527872 Disease Relevance 0.29 Pain Relevance 1.11
We generated recombinant cell lines stably expressing the human PN1 and PN3 sodium channels in Chinese hamster ovary (CHO) cells using inducible expression vectors.
Gene_expression (expressing) of PN1 in ovary associated with sodium channel
3) Confidence 0.77 Published 2003 Journal Recept. Channels Section Abstract Doc Link 14527872 Disease Relevance 0.28 Pain Relevance 0.79
Adrenal chromaffin cells express Na(v)1.7 encoded in SCN9A, which is widely distributed among peripheral autonomic and sensory ganglia, neuroendocrine cells, as well as prostate cancer cell lines.
Gene_expression (express) of SCN9A in ganglia associated with reprotox - general 1
4) Confidence 0.76 Published 2008 Journal Acta Physiol (Oxf) Section Abstract Doc Link 18021327 Disease Relevance 0.39 Pain Relevance 0.23
Reverse transcriptase/polymerase chain reaction (RT-PCR) analysis of mRNA showed the prominent expression of transcripts for SCN9A, which was consistent with the results of real-time quantitative RT-PCR.
Gene_expression (expression) of SCN9A
5) Confidence 0.75 Published 2004 Journal FEBS Lett. Section Abstract Doc Link 15178348 Disease Relevance 0 Pain Relevance 0.32
SCN9A (Nav1.7) was mainly found around the connecting piece with a less intense immunostaining of the sperm head and flagellum.
Gene_expression (found) of SCN9A in sperm associated with nav1.7
6) Confidence 0.74 Published 2009 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2724540 Disease Relevance 0 Pain Relevance 0.55
subunits SCN1A (Nav1.1, 225 bp), SCN2A (Nav1.2, 297 bp), SCN3A (Nav1.3, 367 bp), SCN4A (Nav1.4, 317 bp), SCN5A (Nav1.5, 294 bp), SCN8A (Nav1.6, 207 bp), SCN9A (Nav1.7, 289 bp), SCN10A (Nav1.8, 347 bp), SCN11A (Nav1.9, 272 bp) and the related isoform SCN7A (Nax, 327 bp) were all expressed in human sperm cDNA (Fig 1).
Gene_expression (expressed) of SCN9A in sperm associated with nav1.3, nav1.1, nav1.2, nav1.8, nav1.7, nav1.6 and nav1.9
7) Confidence 0.74 Published 2009 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2724540 Disease Relevance 0 Pain Relevance 0.97
To investigate the mechanisms regulating physiological and pathophysiological Nav1.7 expression we identified the core promoter of this gene (SCN9A) in the human genome.
Spec (investigate) Gene_expression (expression) of SCN9A associated with nav1.7
8) Confidence 0.67 Published 2008 Journal Mol. Cell. Neurosci. Section Abstract Doc Link 18249135 Disease Relevance 0.19 Pain Relevance 0.50
Nociceptive transduction in inflammatory and neuropathic pain involves peripherally expressed voltage-gated sodium channels, such as tetrodotoxin (TTX)-sensitive PN1 and TTX-resistant PN3.
Gene_expression (expressed) of PN1 associated with nociception, tetrodotoxin, inflammation, sodium channel and neuropathic pain
9) Confidence 0.67 Published 2003 Journal Recept. Channels Section Abstract Doc Link 14527872 Disease Relevance 0.30 Pain Relevance 0.76
Adrenal chromaffin cells express Na(v)1.7 encoded in SCN9A, which is widely distributed among peripheral autonomic and sensory ganglia, neuroendocrine cells, as well as prostate cancer cell lines.
Gene_expression (express) of SCN9A in ganglia associated with reprotox - general 1
10) Confidence 0.66 Published 2008 Journal Acta Physiol (Oxf) Section Abstract Doc Link 18021327 Disease Relevance 0.39 Pain Relevance 0.23
Voltage-gated sodium channel expressed in cultured human smooth muscle cells: involvement of SCN9A.
Gene_expression (expressed) of SCN9A in smooth muscle cells associated with sodium channel
11) Confidence 0.65 Published 2004 Journal FEBS Lett. Section Title Doc Link 15178348 Disease Relevance 0 Pain Relevance 0.29
In silico genomic analysis revealed a putative SCN9A 5' non-coding exon approximately 64,000 nucleotides from the translation start site, expression of which commenced at three very closely-positioned transcription initiation sites (TISs), as determined by 5' RACE experiments.
Gene_expression (expression) of SCN9A
12) Confidence 0.60 Published 2008 Journal Mol. Cell. Neurosci. Section Abstract Doc Link 18249135 Disease Relevance 0.18 Pain Relevance 0.49
This region contains the gene SCN9A, encoding the alpha-subunit of the voltage-gated sodium channel, Na(v)1.7, which is strongly expressed in nociceptive neurons.
Gene_expression (expressed) of SCN9A in neurons associated with nociception and sodium channel
13) Confidence 0.60 Published 2006 Journal Nature Section Abstract Doc Link 17167479 Disease Relevance 0.40 Pain Relevance 0.33
Nav1.7, a tetrodotoxin-sensitive sodium channel encoded by the SCN9A gene, and Nav1.8, a tetrodotoxin-insensitive sodium channel, are both expressed in the peripheral nervous system and mainly in the dorsal root ganglia and are closely interconnected.
Gene_expression (expressed) of SCN9A in dorsal root ganglia associated with tetrodotoxin, peripheral nervous system, sodium channel, nav1.8 and nav1.7
14) Confidence 0.59 Published 2010 Journal Dermatology (Basel, Switzerland) Section Body Doc Link PMC2969160 Disease Relevance 1.69 Pain Relevance 1.57
A similar pattern is present with SCN9A, where some
               differences in biophysical properties and the effects of cAMP on splice variants
               have been described [17]. 
Gene_expression (present) of SCN9A
15) Confidence 0.57 Published 2008 Journal PLoS Genetics Section Body Doc Link PMC2432024 Disease Relevance 0.05 Pain Relevance 0.33
Consistent down-regulation of all transcripts was observed, as well as significant changes in the splicing patterns of SCN8A and SCN9A.
Gene_expression (patterns) of SCN9A
16) Confidence 0.55 Published 2004 Journal J. Biol. Chem. Section Abstract Doc Link 15302875 Disease Relevance 0.10 Pain Relevance 0.21
Quantitative RT-PCR and immunostaining for Na(V)1.7 revealed the prominent expression of SCN9A in cultured rASMCs and aorta 48 h after balloon injury but not in native aorta.
Gene_expression (expression) of SCN9A in aorta associated with injury
17) Confidence 0.48 Published 2009 Journal Am. J. Physiol. Heart Circ. Physiol. Section Abstract Doc Link 18978189 Disease Relevance 0.16 Pain Relevance 0.55
In contrast to native aorta, cultured hASMCs strongly expressed SCN9A encoding Na(V)1.7, as determined by quantitative RT-PCR.
Gene_expression (expressed) of SCN9A in aorta
18) Confidence 0.48 Published 2009 Journal Am. J. Physiol. Heart Circ. Physiol. Section Abstract Doc Link 18978189 Disease Relevance 0.09 Pain Relevance 0.54
Adrenal chromaffin cells express Na(v)1.7 encoded in SCN9A, which is widely distributed among peripheral autonomic and sensory ganglia, neuroendocrine cells, as well as prostate cancer cell lines.
Gene_expression (express) of SCN9A in neuroendocrine cells associated with reprotox - general 1
19) Confidence 0.26 Published 2008 Journal Acta Physiol (Oxf) Section Abstract Doc Link 18021327 Disease Relevance 0.39 Pain Relevance 0.23
Adrenal chromaffin cells express Na(v)1.7 encoded in SCN9A, which is widely distributed among peripheral autonomic and sensory ganglia, neuroendocrine cells, as well as prostate cancer cell lines.
Gene_expression (express) of SCN9A in neuroendocrine cells associated with reprotox - general 1
20) Confidence 0.22 Published 2008 Journal Acta Physiol (Oxf) Section Abstract Doc Link 18021327 Disease Relevance 0.39 Pain Relevance 0.23

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