INT113514

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Context Info
Confidence 0.49
First Reported 2003
Last Reported 2006
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 0.85
Pain Relevance 1.46

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

RNA binding (Eif2s1) nucleus (Eif2s1) translation (Eif2s1)
cytoplasm (Eif2s1)
Anatomy Link Frequency
brain 1
Eif2s1 (Mus musculus)
Pain Link Frequency Relevance Heat
withdrawal 5 99.58 Very High Very High Very High
Morphine 4 98.94 Very High Very High Very High
fortral 4 94.28 High High
antagonist 1 89.80 High High
agonist 4 85.80 High High
opiate 5 80.16 Quite High
addiction 2 75.00 Quite High
cINOD 6 64.96 Quite High
cerebral cortex 1 57.40 Quite High
opioid receptor 1 50.84 Quite High
Disease Link Frequency Relevance Heat
Opiate Addiction 4 99.58 Very High Very High Very High
Apoptosis 9 89.92 High High
Cancer 4 75.76 Quite High
Stomach Cancer 1 63.88 Quite High
INFLAMMATION 1 47.56 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These results suggest that the Ca2+-dependent activation of the PERK-eIF2alpha-ATF4 pathway is involved in the upregulation of ER chaperones by celecoxib.
Positive_regulation (activation) of eIF2alpha
1) Confidence 0.49 Published 2006 Journal Oncogene Section Abstract Doc Link 16205636 Disease Relevance 0.58 Pain Relevance 0.24
The main results indicate that chronic heroin/morphine treatment and heroin withdrawal are associated with up-regulation of 35 kDa native Fas (and with different expressions of glycosylated Fas), and also with concomitant increases of dynamin in rat brain.
Positive_regulation (up-regulation) of 35 kDa in brain associated with opiate addiction, withdrawal and morphine
2) Confidence 0.45 Published 2003 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 14530904 Disease Relevance 0.27 Pain Relevance 1.22

General Comments

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