INT113515

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Context Info
Confidence 0.69
First Reported 2003
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 0.95
Pain Relevance 1.92

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Fas) aging (Fas) extracellular region (Fas)
plasma membrane (Fas) nucleus (Fas) cytoplasm (Fas)
Anatomy Link Frequency
brain 2
T cells 2
Fas (Rattus norvegicus)
Pain Link Frequency Relevance Heat
agonist 8 99.96 Very High Very High Very High
Opioid 2 99.46 Very High Very High Very High
withdrawal 5 99.36 Very High Very High Very High
Morphine 7 99.14 Very High Very High Very High
opiate 6 99.14 Very High Very High Very High
cerebral cortex 1 89.80 High High
fortral 4 84.96 Quite High
opioid receptor 1 83.24 Quite High
addiction 3 75.00 Quite High
antagonist 1 62.56 Quite High
Disease Link Frequency Relevance Heat
Hypersensitivity 53 88.28 High High
Opiate Addiction 5 75.00 Quite High
Apoptosis 10 68.24 Quite High
Fatty Liver 29 61.80 Quite High
Disorder Of Lipid Metabolism 13 31.96 Quite Low
Metabolic Syndrome 5 5.00 Very Low Very Low Very Low
Obesity 4 5.00 Very Low Very Low Very Low
Body Weight 4 5.00 Very Low Very Low Very Low
Liver Disease 3 5.00 Very Low Very Low Very Low
Diabetes Mellitus 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Chronic (10-100 mg/kg for 5 days), but not acute (30 mg/kg for 2 h), treatment with morphine (a micro-opioid peptide receptor agonist) induced up-regulation of Fas aggregates in the brain (approximately 110/120 kDa: 39%, and approximately 203 kDa: 89%).
Positive_regulation (induced) of Positive_regulation (up-regulation) of Fas in brain associated with agonist, opioid and morphine
1) Confidence 0.69 Published 2004 Journal Eur. J. Pharmacol. Section Abstract Doc Link 15288576 Disease Relevance 0.06 Pain Relevance 0.64
In heroin-dependent rats, opiate withdrawal (48 h) resulted in a sustained increase in native Fas (107%) and in up-regulation of 51 kDa glycosylated Fas (51%).
Positive_regulation (increase) of Positive_regulation (up-regulation) of Fas associated with opiate and withdrawal
2) Confidence 0.44 Published 2003 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 14530904 Disease Relevance 0.33 Pain Relevance 1.28
OA caused a 1.4-fold induction of FAS mRNA (P < 0.05), and a 2.0-fold induction of G6PDH (P < 0.05).
Positive_regulation (caused) of Positive_regulation (induction) of FAS mRNA
3) Confidence 0.39 Published 2010 Journal Lipids Health Dis Section Body Doc Link PMC2846940 Disease Relevance 0.51 Pain Relevance 0
Since activated T cells express elevated level of Fas, we then determined the cytotoxicity of KC against alloreactive T cells (ATC).
Positive_regulation (activated) of Positive_regulation (elevated) of Fas in T cells
4) Confidence 0.23 Published 2004 Journal Comp Hepatol Section Body Doc Link PMC2410251 Disease Relevance 0.05 Pain Relevance 0

General Comments

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