INT113539

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Context Info
Confidence 0.02
First Reported 2003
Last Reported 2003
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 2
Disease Relevance 0.11
Pain Relevance 1.72

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (ARRB1) plasma membrane (ARRB1) nucleus (ARRB1)
transcription factor binding (ARRB1) cytoplasm (ARRB1)
Anatomy Link Frequency
plasma 4
ARRB1 (Homo sapiens)
Pain Link Frequency Relevance Heat
opioid receptor 28 100.00 Very High Very High Very High
substance P 10 99.98 Very High Very High Very High
Enkephalin 2 78.04 Quite High
mu opioid receptor 2 75.00 Quite High
Disease Link Frequency Relevance Heat
Nociception 2 55.08 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Interestingly, in cells coexpressing MOR1 and NK1 both DAMGO and SP induced the recruitment of beta-arrestin to the plasma membrane and cointernalization of NK1-MOR1 heterodimers with beta-arrestin into the same endosomal compartment.
Positive_regulation (induced) of beta-arrestin Binding (recruitment) of in plasma associated with opioid receptor and substance p
1) Confidence 0.02 Published 2003 Journal J. Biol. Chem. Section Abstract Doc Link 14532289 Disease Relevance 0.06 Pain Relevance 0.85
Interestingly, in cells coexpressing MOR1 and NK1 both DAMGO and SP induced the recruitment of beta-arrestin to the plasma membrane and cointernalization of NK1-MOR1 heterodimers with beta-arrestin into the same endosomal compartment.
Positive_regulation (induced) of beta-arrestin Binding (cointernalization) of in plasma associated with opioid receptor and substance p
2) Confidence 0.02 Published 2003 Journal J. Biol. Chem. Section Abstract Doc Link 14532289 Disease Relevance 0.06 Pain Relevance 0.87

General Comments

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