INT11354

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Context Info
Confidence 0.61
First Reported 1992
Last Reported 2008
Negated 1
Speculated 6
Reported most in Abstract
Documents 11
Total Number 17
Disease Relevance 8.66
Pain Relevance 4.42

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (SERPINE1) extracellular region (SERPINE1) plasma membrane (SERPINE1)
Anatomy Link Frequency
articular cartilage 7
chondrocytes 5
cartilage 2
fibroblasts 2
synovium 2
SERPINE1 (Homo sapiens)
Pain Link Frequency Relevance Heat
cINOD 19 100.00 Very High Very High Very High
Inflammation 11 100.00 Very High Very High Very High
cytokine 50 99.98 Very High Very High Very High
dexamethasone 7 99.60 Very High Very High Very High
Osteoarthritis 22 99.56 Very High Very High Very High
metalloproteinase 5 99.44 Very High Very High Very High
rheumatoid arthritis 20 99.28 Very High Very High Very High
Arthritis 9 91.32 High High
Inflammatory mediators 2 87.88 High High
agonist 2 74.88 Quite High
Disease Link Frequency Relevance Heat
INFLAMMATION 23 100.00 Very High Very High Very High
Osteoarthritis 22 99.56 Very High Very High Very High
Rheumatoid Arthritis 24 99.28 Very High Very High Very High
Knee Osteoarthritis 1 97.44 Very High Very High Very High
Cancer 71 97.32 Very High Very High Very High
Necrosis 14 97.08 Very High Very High Very High
Metastasis 15 92.92 High High
Recurrence 12 91.80 High High
Wound Healing 5 91.40 High High
Arthritis 17 91.32 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Transcriptional regulation of plasminogen activator inhibitor-1 expression in human synovial fibroblasts by prostaglandin E2: mediation by protein kinase A and role of interleukin-1.
Regulation (regulation) of Gene_expression (expression) of plasminogen activator in fibroblasts
1) Confidence 0.61 Published 1994 Journal Mol. Cell. Endocrinol. Section Title Doc Link 7525383 Disease Relevance 0.27 Pain Relevance 0.20
Recombinant human cytokines were examined for their effects on plasminogen activator inhibitor-1 (PAI-1) production by human articular cartilage and chondrocyte monolayer cultures.
Spec (examined) Regulation (effects) of Gene_expression (production) of plasminogen activator in articular cartilage associated with cytokine
2) Confidence 0.57 Published 1994 Journal Biochim. Biophys. Acta Section Abstract Doc Link 8054359 Disease Relevance 0.30 Pain Relevance 0.13
For the univariate and multivariate analyses, we investigated the prognostic value of uPA and PAI-1 mRNA levels by using the median of expression generating "high" and "low" level groups.
Spec (investigated) Regulation (value) of Gene_expression (levels) of PAI-1 mRNA
3) Confidence 0.45 Published 2006 Journal BMC Cancer Section Body Doc Link PMC1564186 Disease Relevance 0.95 Pain Relevance 0
Data concerning the activation of PKC suggest that the expression, synthesis and release of the PAI-1 may be differentially regulated in normal human synoviocytes.
Regulation (regulated) of Gene_expression (expression) of PAI-1
4) Confidence 0.44 Published 1994 Journal Mol. Cell. Endocrinol. Section Abstract Doc Link 7525383 Disease Relevance 0 Pain Relevance 0.14
The two drugs, at therapeutic concentrations, exerted a stimulatory effect on the synthesis of PAI-1 whereas the synthesis of IL-6 was significantly reduced by both NSAIDs.
Regulation (effect) of Gene_expression (synthesis) of PAI-1
5) Confidence 0.42 Published 1997 Journal Clin. Exp. Rheumatol. Section Body Doc Link 9272300 Disease Relevance 0.09 Pain Relevance 0
The anti-inflammatory drugs, indomethacin and dexamethasone, did not appear to modulate PAI-1 levels in cultures of cartilage tissue.
Regulation (modulate) of Gene_expression (levels) of PAI-1 in cartilage associated with inflammation, cinod and dexamethasone
6) Confidence 0.42 Published 1994 Journal Biochim. Biophys. Acta Section Abstract Doc Link 8054359 Disease Relevance 0.40 Pain Relevance 0.42
Recombinant human cytokines were examined for their effects on plasminogen activator inhibitor-1 (PAI-1) production by human articular cartilage and chondrocyte monolayer cultures.
Spec (examined) Regulation (effects) of Gene_expression (production) of PAI-1 in articular cartilage associated with cytokine
7) Confidence 0.42 Published 1994 Journal Biochim. Biophys. Acta Section Abstract Doc Link 8054359 Disease Relevance 0.30 Pain Relevance 0.13
Tiaprofenic acid also exerted a suppressive effect on the synthesis of PAI-1 in both OA and RA synovial membranes, and on the release of PAI-2 in RA synovium.
Regulation (effect) of Gene_expression (synthesis) of PAI in synovium associated with rheumatoid arthritis and osteoarthritis
8) Confidence 0.39 Published 1992 Journal Br. J. Rheumatol. Section Abstract Doc Link 1555050 Disease Relevance 1.23 Pain Relevance 0.56
The effect of therapeutic and pharmacological concentrations of tiaprofenic acid, a non-steroidal anti-inflammatory drug (NSAID), on the synthesis of the plasminogen activators, urokinase plasminogen activator (uPA) and tissue plasminogen activator (tPA), and the plasminogen activator inhibitors 1 and 2 (PAI-1 and PAI-2), by human synovial membranes isolated from osteoarthritis (OA) and rheumatoid arthritis (RA) sufferers was evaluated.
Regulation (effect) of Gene_expression (synthesis) of plasminogen activator associated with inflammation, rheumatoid arthritis, cinod and osteoarthritis
9) Confidence 0.39 Published 1992 Journal Br. J. Rheumatol. Section Abstract Doc Link 1555050 Disease Relevance 0.94 Pain Relevance 0.49
The effect of therapeutic and pharmacological concentrations of tiaprofenic acid, a non-steroidal anti-inflammatory drug (NSAID), on the synthesis of the plasminogen activators, urokinase plasminogen activator (uPA) and tissue plasminogen activator (tPA), and the plasminogen activator inhibitors 1 and 2 (PAI-1 and PAI-2), by human synovial membranes isolated from osteoarthritis (OA) and rheumatoid arthritis (RA) sufferers was evaluated.
Regulation (effect) of Gene_expression (synthesis) of plasminogen activator associated with inflammation, rheumatoid arthritis, cinod and osteoarthritis
10) Confidence 0.34 Published 1992 Journal Br. J. Rheumatol. Section Abstract Doc Link 1555050 Disease Relevance 0.87 Pain Relevance 0.46
The effect of therapeutic and pharmacological concentrations of tiaprofenic acid, a non-steroidal anti-inflammatory drug (NSAID), on the synthesis of the plasminogen activators, urokinase plasminogen activator (uPA) and tissue plasminogen activator (tPA), and the plasminogen activator inhibitors 1 and 2 (PAI-1 and PAI-2), by human synovial membranes isolated from osteoarthritis (OA) and rheumatoid arthritis (RA) sufferers was evaluated.
Regulation (effect) of Gene_expression (synthesis) of plasminogen activator associated with inflammation, rheumatoid arthritis, cinod and osteoarthritis
11) Confidence 0.34 Published 1992 Journal Br. J. Rheumatol. Section Abstract Doc Link 1555050 Disease Relevance 0.80 Pain Relevance 0.42
OBJECTIVES: The purpose of this study was to examine the ex vivo effects of nonsteroidal anti-inflammatory drugs (NSAIDs) on the expression of urokinase-type plasminogen activator (u-PA), PA inhibitor-1 (PAI-1) and gelatinases [matrix metalloproteinase (MMP)-2 and MMP-9] in the early knee osteoarthritis (OA) of humans.
Spec (examine) Regulation (effects) of Spec (examine) Gene_expression (expression) of PAI-1 in knee associated with inflammation, knee osteoarthritis, metalloproteinase, cinod and osteoarthritis
12) Confidence 0.31 Published 2008 Journal Clin. Biochem. Section Abstract Doc Link 17996201 Disease Relevance 0.35 Pain Relevance 0.47
Analysis on a gene-by-gene basis demonstrated higher expression levels of PAI-1, COX-2, uPAR and MMP1 in STs compared to their paired CBs, whereas no changes were observed for all other genes.
Neg (no) Regulation (changes) of Gene_expression (expression) of PAI-1
13) Confidence 0.26 Published 2006 Journal Breast Cancer Res Section Body Doc Link PMC1779463 Disease Relevance 0.77 Pain Relevance 0.12
Cytokine modulation of plasminogen activator inhibitor-1 (PAI-1) production by human articular cartilage and chondrocytes.
Regulation (modulation) of Gene_expression (production) of PAI-1 in chondrocytes associated with cytokine
14) Confidence 0.25 Published 1994 Journal Biochim. Biophys. Acta Section Title Doc Link 8054359 Disease Relevance 0.40 Pain Relevance 0.30
Recombinant human cytokines were examined for their effects on plasminogen activator inhibitor-1 (PAI-1) production by human articular cartilage and chondrocyte monolayer cultures.
Spec (examined) Regulation (effects) of in chondrocyte Gene_expression (production) of plasminogen activator in articular cartilage associated with cytokine
15) Confidence 0.19 Published 1994 Journal Biochim. Biophys. Acta Section Abstract Doc Link 8054359 Disease Relevance 0.30 Pain Relevance 0.13
Recombinant human cytokines were examined for their effects on plasminogen activator inhibitor-1 (PAI-1) production by human articular cartilage and chondrocyte monolayer cultures.
Spec (examined) Regulation (effects) of in chondrocyte Gene_expression (production) of PAI-1 in articular cartilage associated with cytokine
16) Confidence 0.14 Published 1994 Journal Biochim. Biophys. Acta Section Abstract Doc Link 8054359 Disease Relevance 0.30 Pain Relevance 0.13
Cytokine modulation of plasminogen activator inhibitor-1 (PAI-1) production by human articular cartilage and chondrocytes.
Regulation (modulation) of in articular cartilage Gene_expression (production) of PAI-1 in chondrocytes associated with cytokine
17) Confidence 0.09 Published 1994 Journal Biochim. Biophys. Acta Section Title Doc Link 8054359 Disease Relevance 0.40 Pain Relevance 0.30

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