INT113540

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Context Info
Confidence 0.04
First Reported 2003
Last Reported 2003
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 2
Disease Relevance 0.10
Pain Relevance 1.10

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (OPRM1, Tac1) extracellular space (Tac1) extracellular region (Tac1)
Golgi apparatus (OPRM1) endoplasmic reticulum (OPRM1) signal transducer activity (OPRM1)
Anatomy Link Frequency
brain 1
OPRM1 (Homo sapiens)
Tac1 (Mus musculus)
Pain Link Frequency Relevance Heat
opioid receptor 28 100.00 Very High Very High Very High
substance P 10 100.00 Very High Very High Very High
mu opioid receptor 2 75.00 Quite High
Enkephalin 2 63.64 Quite High
Disease Link Frequency Relevance Heat
Nociception 2 99.84 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Together, our findings indicate that MOR1 by virtue of its physical interaction with NK1 is sequestered via an endocytotic pathway with delayed recycling and resensitization kinetics.
MOR1 Binding (interaction) of NK1 associated with opioid receptor
1) Confidence 0.04 Published 2003 Journal J. Biol. Chem. Section Abstract Doc Link 14532289 Disease Relevance 0 Pain Relevance 0.68
The micro-opioid receptor (MOR1) and the substance P receptor (NK1) coexist and functionally interact in nociceptive brain regions; however, a molecular basis for this interaction has not been established.
MOR1 Binding (interact) of NK1 in brain associated with nociception, opioid receptor and substance p
2) Confidence 0.03 Published 2003 Journal J. Biol. Chem. Section Abstract Doc Link 14532289 Disease Relevance 0.10 Pain Relevance 0.42

General Comments

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