INT113550

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Context Info
Confidence 0.30
First Reported 2003
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 6
Total Number 6
Disease Relevance 5.24
Pain Relevance 1.91

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (FN1, VTN) extracellular region (FN1, VTN) cell adhesion (FN1, VTN)
proteinaceous extracellular matrix (FN1, VTN) extracellular matrix organization (VTN)
Anatomy Link Frequency
PC-3 5
FN1 (Homo sapiens)
VTN (Homo sapiens)
Pain Link Frequency Relevance Heat
aspirin 45 99.28 Very High Very High Very High
cINOD 5 83.64 Quite High
Inflammation 3 5.00 Very Low Very Low Very Low
headache 3 5.00 Very Low Very Low Very Low
Pain 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Adhesions 25 99.64 Very High Very High Very High
Prostate Cancer 20 96.44 Very High Very High Very High
Pancreatic Cancer 5 87.24 High High
Leptospirosis 29 86.96 High High
Metastasis 15 83.84 Quite High
INFLAMMATION 8 83.40 Quite High
Cancer 15 81.16 Quite High
Hemophilus Infection 1 78.80 Quite High
Infection 9 29.20 Quite Low
Injury 2 28.32 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Finally, aspirin suppressed adhesion of PC-3 cells to fibronectin (FN), which binds to an alpha3beta1 integrin receptor, and to vitronectin (VN), which binds to alphavbeta3 integrin receptor.
FN Binding (binds) of vitronectin in PC-3 associated with aspirin and adhesions
1) Confidence 0.30 Published 2003 Journal Int. J. Oncol. Section Abstract Doc Link 14532966 Disease Relevance 1.04 Pain Relevance 0.38
Finally, aspirin suppressed adhesion of PC-3 cells to fibronectin (FN), which binds to an alpha3beta1 integrin receptor, and to vitronectin (VN), which binds to alphavbeta3 integrin receptor.
fibronectin Binding (binds) of VN in PC-3 associated with aspirin and adhesions
2) Confidence 0.30 Published 2003 Journal Int. J. Oncol. Section Abstract Doc Link 14532966 Disease Relevance 1.09 Pain Relevance 0.39
Finally, aspirin suppressed adhesion of PC-3 cells to fibronectin (FN), which binds to an alpha3beta1 integrin receptor, and to vitronectin (VN), which binds to alphavbeta3 integrin receptor.
FN Binding (binds) of VN in PC-3 associated with aspirin and adhesions
3) Confidence 0.30 Published 2003 Journal Int. J. Oncol. Section Abstract Doc Link 14532966 Disease Relevance 1.04 Pain Relevance 0.39
Finally, aspirin suppressed adhesion of PC-3 cells to fibronectin (FN), which binds to an alpha3beta1 integrin receptor, and to vitronectin (VN), which binds to alphavbeta3 integrin receptor.
fibronectin Binding (binds) of vitronectin in PC-3 associated with aspirin and adhesions
4) Confidence 0.30 Published 2003 Journal Int. J. Oncol. Section Abstract Doc Link 14532966 Disease Relevance 1.09 Pain Relevance 0.39
Altogether, our data suggests that aspirin inhibits the formation of uPA-uPAR-FN-alpha3beta1 and uPA-uPAR-VN-alphavbeta3 complexes, resulting in the suppression of cell adhesion and cell motility of the highly invasive prostate cancer cells PC-3.
FN Binding (complexes) of VN in PC-3 associated with aspirin, prostate cancer and adhesions
5) Confidence 0.20 Published 2003 Journal Int. J. Oncol. Section Abstract Doc Link 14532966 Disease Relevance 0.81 Pain Relevance 0.37
Emp, a cell surface protein of Staphylococcus aureus, strongly interacts with fibronectin, fibrinogen, collagen, and vitronectin [40].
fibronectin Binding (interacts) of vitronectin
6) Confidence 0.00 Published 2008 Journal BMC Microbiol Section Body Doc Link PMC2386478 Disease Relevance 0.17 Pain Relevance 0

General Comments

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