INT113552

Context Info Confidence 0.31 First Reported 2003 Last Reported 2010 Negated 0 Speculated 0 Reported most in Abstract Documents 4 Total Number 4 Disease Relevance 3.09 Pain Relevance 0.72

signal transduction (PLAU, PLAUR) extracellular region (PLAU, PLAUR) plasma membrane (PLAU, PLAUR) peptidase activity (PLAU) extracellular space (PLAU) enzyme binding (PLAUR)

Anatomy Link Frequency extracellular matrix 2 PC-3 1 PLAU (Homo sapiens) PLAUR (Homo sapiens)

Pain Link Frequency Relevance Heat aspirin 27 99.46 cINOD 3 75.36 tolerance 1 5.00 Pain 1 5.00

Disease Link Frequency Relevance Heat Adhesions 12 99.20 Prostate Cancer 12 96.44 Cancer 30 94.72 Metastasis 33 93.40 Pancreatic Cancer 3 78.96 INFLAMMATION 3 75.12 Skin Cancer 47 53.60 Alzheimer's Dementia 1 19.68 Ovarian Cancer 1 6.96 Mouth Cancer 4 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Altogether, our data suggests that aspirin inhibits the formation of uPA-uPAR-FN-alpha3beta1 and uPA-uPAR-VN-alphavbeta3 complexes, resulting in the suppression of cell adhesion and cell motility of the highly invasive prostate cancer cells PC-3.

uPA Binding (complexes) of uPAR in PC-3 associated with aspirin, prostate cancer and adhesions

1) Confidence 0.31 Published 2003 Journal Int. J. Oncol. Section Abstract Doc Link 14532966 Disease Relevance 0.82 Pain Relevance 0.37

In addition to the proteolytic activity of uPA, which degrades the extracellular matrix, uPA also binds to its receptor (uPAR) and controls cell adhesion and migration through the reorganization of actin cytoskeleton.

uPA Binding (binds) of uPAR in extracellular matrix associated with adhesions

2) Confidence 0.30 Published 2003 Journal Int. J. Oncol. Section Abstract Doc Link 14532966 Disease Relevance 0.88 Pain Relevance 0.17

In addition to the proteolytic activity of uPA, which degrades the extracellular matrix, uPA also binds to its receptor (uPAR) and controls cell adhesion and migration through the reorganization of actin cytoskeleton.

uPA Binding (binds) of uPAR in extracellular matrix associated with adhesions

3) Confidence 0.30 Published 2003 Journal Int. J. Oncol. Section Abstract Doc Link 14532966 Disease Relevance 0.87 Pain Relevance 0.17

Several other proteins, fibrin, uPA receptor (uPAR), and two main PA inhibitors, PAI-1 and PAI-2, are also important in this process.

uPA Binding (receptor) of uPAR

4) Confidence 0.08 Published 2010 Journal International Journal of Molecular Sciences Section Body Doc Link PMC2956083 Disease Relevance 0.51 Pain Relevance 0

General Comments

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