INT113558

Context Info Confidence 0.41 First Reported 2003 Last Reported 2003 Negated 0 Speculated 0 Reported most in Abstract Documents 1 Total Number 1 Disease Relevance 0.97 Pain Relevance 0.29

signal transduction (NFKB1, PLAU) nucleoplasm (NFKB1) mitochondrion (NFKB1) cytoplasm (NFKB1) cytosol (NFKB1) peptidase activity (PLAU)

NFKB1 (Homo sapiens) PLAU (Homo sapiens)

Pain Link Frequency Relevance Heat aspirin 9 95.76 cINOD 1 94.32

Disease Link Frequency Relevance Heat Cancer 3 98.44 INFLAMMATION 1 92.88 Adhesions 4 91.36 Pancreatic Cancer 1 85.68 Metastasis 3 80.36 Prostate Cancer 4 75.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

We have recently demonstrated that constitutively active nuclear factor-kappa B (NF-kappaB) is responsible for the increased secretion of uPA and that inhibition of NF-kappaB suppresses secretion of uPA and cell migration of highly invasive cancer cells.

Negative_regulation (inhibition) of NF-kappaB Negative_regulation (suppresses) of Localization (secretion) of uPA associated with cancer

1) Confidence 0.41 Published 2003 Journal Int. J. Oncol. Section Abstract Doc Link 14532966 Disease Relevance 0.97 Pain Relevance 0.29

General Comments

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