INT113559

Context Info Confidence 0.28 First Reported 2003 Last Reported 2003 Negated 0 Speculated 0 Reported most in Abstract Documents 1 Total Number 1 Disease Relevance 0.82 Pain Relevance 0.37

extracellular space (PLAU, VTN) extracellular region (PLAU, VTN) peptidase activity (PLAU) signal transduction (PLAU) cell adhesion (VTN) proteinaceous extracellular matrix (VTN)

Anatomy Link Frequency PC-3 1 PLAU (Homo sapiens) VTN (Homo sapiens)

Pain Link Frequency Relevance Heat aspirin 9 99.46 cINOD 1 75.36

Disease Link Frequency Relevance Heat Adhesions 4 98.44 Prostate Cancer 4 96.44 Metastasis 3 83.84 Pancreatic Cancer 1 78.96 INFLAMMATION 1 75.12 Cancer 3 72.88

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Altogether, our data suggests that aspirin inhibits the formation of uPA-uPAR-FN-alpha3beta1 and uPA-uPAR-VN-alphavbeta3 complexes, resulting in the suppression of cell adhesion and cell motility of the highly invasive prostate cancer cells PC-3.

uPA Binding (complexes) of VN in PC-3 associated with aspirin, prostate cancer and adhesions

1) Confidence 0.28 Published 2003 Journal Int. J. Oncol. Section Abstract Doc Link 14532966 Disease Relevance 0.82 Pain Relevance 0.37

General Comments

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