INT113564

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.48
First Reported 2003
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 4
Disease Relevance 5.15
Pain Relevance 0.41

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (PLAUR) extracellular region (PLAUR) plasma membrane (PLAUR)
enzyme binding (PLAUR)
Anatomy Link Frequency
lymph node 2
PC-3 1
PLAUR (Homo sapiens)
Pain Link Frequency Relevance Heat
aspirin 9 99.00 Very High Very High Very High
cINOD 1 87.48 High High
cytokine 5 53.44 Quite High
Kinase C 1 49.52 Quite Low
metalloproteinase 24 46.72 Quite Low
depression 2 42.08 Quite Low
palliative 2 5.00 Very Low Very Low Very Low
Spinal cord 1 5.00 Very Low Very Low Very Low
Neurotransmitter 1 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Metastasis 62 99.84 Very High Very High Very High
Hypoxia 8 99.16 Very High Very High Very High
Melanoma 146 97.28 Very High Very High Very High
Cancer 130 97.12 Very High Very High Very High
Prostate Cancer 91 96.68 Very High Very High Very High
Adhesions 32 96.16 Very High Very High Very High
Pancreatic Cancer 3 91.08 High High
INFLAMMATION 1 87.24 High High
Malignant Neoplastic Disease 8 85.04 High High
Colon Cancer 2 77.32 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Furthermore, aspirin inhibited migration of PC-3 cells, suggesting an effect on the uPA-uPAR signaling complex.
Regulation (effect) of uPAR in PC-3 associated with aspirin
1) Confidence 0.48 Published 2003 Journal Int. J. Oncol. Section Abstract Doc Link 14532966 Disease Relevance 1.09 Pain Relevance 0.38
Hypoxia can promote lymph node metastasis via up-regulation of PLAUR [39], and up-regulation of HIF1a, JUN and PLAUR in our invasive cell lines hints at possible activation of JUN/AP1 and HIF/ARNT pathways in melanoma (Figure 5).
Regulation (regulation) of PLAUR in lymph node associated with melanoma, hypoxia and metastasis
2) Confidence 0.32 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2794539 Disease Relevance 1.69 Pain Relevance 0
Hypoxia can promote lymph node metastasis via up-regulation of PLAUR [39], and up-regulation of HIF1a, JUN and PLAUR in our invasive cell lines hints at possible activation of JUN/AP1 and HIF/ARNT pathways in melanoma (Figure 5).
Regulation (regulation) of PLAUR in lymph node associated with melanoma, hypoxia and metastasis
3) Confidence 0.16 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2794539 Disease Relevance 1.63 Pain Relevance 0
Various cell-associated serine proteases and their respective receptors have been shown to up-regulate u-PAR, giving the u-PA/u-PAR/PAI-1 system prognostic significance in several tumor types [101], including PCa.
Regulation (regulate) of u-PAR associated with cancer and prostate cancer
4) Confidence 0.03 Published 2004 Journal Reprod Biol Endocrinol Section Body Doc Link PMC320496 Disease Relevance 0.73 Pain Relevance 0.03

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox