INT113565

Context Info Confidence 0.58 First Reported 2003 Last Reported 2010 Negated 0 Speculated 4 Reported most in Body Documents 6 Total Number 10 Disease Relevance 5.80 Pain Relevance 0.66

peptidase activity (PLAU) signal transduction (PLAU) extracellular space (PLAU) extracellular region (PLAU) plasma membrane (PLAU)

Anatomy Link Frequency lymph node 1 PC-3 1 PLAU (Homo sapiens)

Pain Link Frequency Relevance Heat metalloproteinase 2 100.00 aspirin 9 99.00 Inflammatory response 10 95.92 cINOD 1 87.48 withdrawal 4 82.64 palliative 12 5.00 cytokine 8 5.00 Inflammation 8 5.00 methotrexate 6 5.00 endometriosis 4 5.00

Disease Link Frequency Relevance Heat Breast Cancer 206 98.00 Cancer 175 97.20 Prostate Cancer 4 96.68 Adhesions 8 95.76 INFLAMMATION 21 95.56 Recurrence 60 95.44 Metastasis 81 94.68 Increased Venous Pressure Under Development 2 91.36 Pancreatic Cancer 1 91.08 Second Primary Neoplasms 6 90.80

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Furthermore, aspirin inhibited migration of PC-3 cells, suggesting an effect on the uPA-uPAR signaling complex.

Regulation (effect) of uPA in PC-3 associated with aspirin

1) Confidence 0.58 Published 2003 Journal Int. J. Oncol. Section Abstract Doc Link 14532966 Disease Relevance 1.09 Pain Relevance 0.38

MSE, striking up-regulation of metalloproteinases (MMPs and ADAMs), serine proteases [the plasminogen activators, uPA (PLAU) and tPA (PLAT)], and their inhibitors, was observed [14].

Regulation (regulation) of PLAU associated with metalloproteinase

2) Confidence 0.37 Published 2006 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1775064 Disease Relevance 0.26 Pain Relevance 0.14

MSE, striking up-regulation of metalloproteinases (MMPs and ADAMs), serine proteases [the plasminogen activators, uPA (PLAU) and tPA (PLAT)], and their inhibitors, was observed [14].

Regulation (regulation) of uPA associated with metalloproteinase

3) Confidence 0.37 Published 2006 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1775064 Disease Relevance 0.26 Pain Relevance 0.14

Univariate and multivariate analysis of uPA and PAI-1 mRNA values for BCS

Regulation (values) of uPA

4) Confidence 0.27 Published 2006 Journal BMC Cancer Section Body Doc Link PMC1564186 Disease Relevance 0.98 Pain Relevance 0

We investigated the prognostic value of uPA and PAI-1 mRNA levels by considering the median of expression as a cut-off generating a "high" and a "low" level group.

Spec (investigated) Regulation (value) of uPA

5) Confidence 0.27 Published 2006 Journal BMC Cancer Section Body Doc Link PMC1564186 Disease Relevance 0.44 Pain Relevance 0

For the univariate and multivariate analyses, we investigated the prognostic value of uPA and PAI-1 mRNA levels by using the median of expression generating "high" and "low" level groups.

Spec (investigated) Regulation (value) of uPA

6) Confidence 0.27 Published 2006 Journal BMC Cancer Section Body Doc Link PMC1564186 Disease Relevance 0.95 Pain Relevance 0

In this study, we investigated the prognostic value of uPA and PAI-1 at the mRNA level in lymph node- and hormone receptor-positive breast cancer.

Spec (investigated) Regulation (value) of uPA in lymph node associated with breast cancer

7) Confidence 0.27 Published 2006 Journal BMC Cancer Section Abstract Doc Link PMC1564186 Disease Relevance 0.48 Pain Relevance 0

We investigated the prognostic value of uPA and PAI-1 at the mRNA level as measured by real-time quantitative RT-PCR.

Spec (investigated) Regulation (value) of uPA

8) Confidence 0.27 Published 2006 Journal BMC Cancer Section Abstract Doc Link PMC1564186 Disease Relevance 0.66 Pain Relevance 0

UPA and PAI-1 mRNA values were compared with clinical, histological and biological features of tumors using appropriate statistical tests.

Regulation (values) of UPA associated with cancer

9) Confidence 0.23 Published 2006 Journal BMC Cancer Section Body Doc Link PMC1564186 Disease Relevance 0.70 Pain Relevance 0

Efficacy of UPA

Regulation (Efficacy) of UPA

10) Confidence 0.19 Published 2010 Journal International Journal of Women's Health Section Body Doc Link PMC2971744 Disease Relevance 0 Pain Relevance 0

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